Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses

Blocking CCR8 inhibits entry of metastases from the collecting lymphatic vessel into the lymph node.

[1]  Jinhua Zheng,et al.  Morphological Studies of Lymphatic Labyrinths in the Rat Mesenteric Lymph Node , 2012, Anatomical record.

[2]  R. Förster,et al.  Lymph node homing of T cells and dendritic cells via afferent lymphatics. , 2012, Trends in immunology.

[3]  L. Ng,et al.  Intravital multiphoton imaging of immune responses in the mouse ear skin , 2012, Nature Protocols.

[4]  Jeffrey Wyckoff,et al.  Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging , 2011, Nature Protocols.

[5]  J. Segall,et al.  High-resolution multiphoton imaging of tumors in vivo. , 2011, Cold Spring Harbor protocols.

[6]  Lai Guan Ng,et al.  DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling , 2011, The Journal of experimental medicine.

[7]  S. Halle,et al.  Afferent lymph–derived T cells and DCs use different chemokine receptor CCR7–dependent routes for entry into the lymph node and intranodal migration , 2011, Nature Immunology.

[8]  John S. Condeelis,et al.  Chemotaxis in cancer , 2011, Nature Reviews Cancer.

[9]  R. Alon,et al.  Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers. , 2011, Experimental cell research.

[10]  S. Lira,et al.  Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ TH2 cells , 2011, Nature Immunology.

[11]  A. Ruddell,et al.  Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation , 2010, The Journal of experimental medicine.

[12]  M. Skobe,et al.  Vascular endothelial growth factor-C induces lymphangitic carcinomatosis, an extremely aggressive form of lung metastases. , 2010, Cancer research.

[13]  M. Skobe,et al.  Inflamed Lymphatic Endothelium Suppresses Dendritic Cell Maturation and Function via Mac-1/ICAM-1-Dependent Mechanism1 , 2009, The Journal of Immunology.

[14]  Joachim P Spatz,et al.  Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. , 2009, Immunity.

[15]  U. V. von Andrian,et al.  Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. , 2009, Immunity.

[16]  Klaus Ley,et al.  Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells. , 2008, Current opinion in cell biology.

[17]  P. V. van Diest,et al.  In-transit lymph node metastases in breast cancer: a possible source of local recurrence after Sentinel Node procedure , 2008, Journal of Clinical Pathology.

[18]  Y. Ohtani,et al.  Structure and function of rat lymph nodes. , 2008, Archives of histology and cytology.

[19]  S. Butz,et al.  Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node , 2008, European journal of immunology.

[20]  N. D. Di Paolo,et al.  Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells , 2007, Nature.

[21]  Katsuhiro Hayashi,et al.  Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels. , 2007, Cancer research.

[22]  T. Phan,et al.  Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells , 2007, Nature Immunology.

[23]  Melody A Swartz,et al.  Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. , 2007, Cancer cell.

[24]  S. Natsugoe,et al.  Prognostic value of CCR7 expression in gastric cancer. , 2007, Hepato-gastroenterology.

[25]  D. Bates,et al.  Chemokine-mediated migration of melanoma cells towards lymphatics – a mechanism contributing to metastasis , 2007, Oncogene.

[26]  M. Jenkins,et al.  The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. , 2007, Immunity.

[27]  A. Mcdonald,et al.  CCR8 Expression Identifies CD4 Memory T Cells Enriched for FOXP3+ Regulatory and Th2 Effector Lymphocytes , 2006, The Journal of Immunology.

[28]  R. Elashoff,et al.  Sentinel-node biopsy or nodal observation in melanoma. , 2006, The New England journal of medicine.

[29]  S. Goerdt,et al.  Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis. , 2006, The Journal of pathology.

[30]  Vyacheslav Kalchenko,et al.  Real-time imaging of lymphogenic metastasis in orthotopic human breast cancer. , 2006, Cancer research.

[31]  Lisa M. Ebert,et al.  Homing and Function of Human Skin γδ T Cells and NK Cells: Relevance for Tumor Surveillance , 2006, The Journal of Immunology.

[32]  M. Skobe,et al.  Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2. , 2006, Cancer research.

[33]  Tatiana V. Petrova,et al.  Lymphangiogenesis in development and human disease , 2005, Nature.

[34]  G. Hortobagyi,et al.  CCR7 and CXCR4 as Novel Biomarkers Predicting Axillary Lymph Node Metastasis in T1 Breast Cancer , 2005, Clinical Cancer Research.

[35]  E. Butcher,et al.  Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues , 2005, Nature Immunology.

[36]  T. Pawlik,et al.  The risk of in-transit melanoma metastasis depends on tumor biology and not the surgical approach to regional lymph nodes. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[37]  H. Zentgraf,et al.  CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to cites of atopic skin inflammation , 2005, The Journal of Immunology.

[38]  Antonio Alcami,et al.  The chemokine receptor D6 limits the inflammatory response in vivo , 2005, Nature Immunology.

[39]  S. Stacker,et al.  Focus on lymphangiogenesis in tumor metastasis. , 2005, Cancer cell.

[40]  Randall L. Lindquist,et al.  Visualizing dendritic cell networks in vivo , 2004, Nature Immunology.

[41]  F. Tacke,et al.  Role of CCR8 and Other Chemokine Pathways in the Migration of Monocyte-derived Dendritic Cells to Lymph Nodes , 2004, The Journal of experimental medicine.

[42]  J. Snick,et al.  Autocrine stimulation of rhadinovirus-transformed T cells by the chemokine CCL1/I-309 , 2004, Oncogene.

[43]  M. Green,et al.  The microanatomic location of metastatic melanoma in sentinel lymph nodes predicts nonsentinel lymph node involvement. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[44]  Lisa M. Ebert,et al.  A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells , 2004, Journal of Experimental Medicine.

[45]  P. Laakkonen,et al.  Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates. , 2004, Journal of the American Society of Nephrology : JASN.

[46]  J. Fallon,et al.  Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. , 2004, Blood.

[47]  J. Segall,et al.  Intravital imaging of cell movement in tumours , 2003, Nature Reviews Cancer.

[48]  Ulrich H. von Andrian,et al.  Homing and cellular traffic in lymph nodes , 2003, Nature Reviews Immunology.

[49]  A. Zlotnik,et al.  Therapeutic applications in the chemokine superfamily. , 2003, Current opinion in chemical biology.

[50]  Y. Ohtani,et al.  Fluid and cellular pathways of rat lymph nodes in relation to lymphatic labyrinths and Aquaporin-1 expression. , 2003, Archives of histology and cytology.

[51]  S. Nathanson,et al.  Insights into the mechanisms of lymph node metastasis , 2003, Cancer.

[52]  J. Renauld,et al.  CCR8‐dependent activation of the RAS/MAPK pathway mediates anti‐apoptotic activity of I‐309/CCL1 and vMIP‐I , 2003, European journal of immunology.

[53]  M. Skobe,et al.  Lymphatic Vessel Activation in Cancer , 2002, Annals of the New York Academy of Sciences.

[54]  M. Skobe,et al.  Molecular characterization of lymphatic endothelial cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[55]  C. Tsopelas,et al.  Why certain dyes are useful for localizing the sentinel lymph node. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[56]  F. Tanaka,et al.  Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. , 2002, Cancer research.

[57]  H. Wiley,et al.  Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. , 2001, Journal of the National Cancer Institute.

[58]  M. Skobe,et al.  Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma. , 2001, The American journal of pathology.

[59]  M. Swartz,et al.  The physiology of the lymphatic system. , 2001, Advanced drug delivery reviews.

[60]  Martin F. Mihm,et al.  Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[61]  D. Saul,et al.  Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309. , 2001, Blood.

[62]  T. Schwartz,et al.  MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8 , 2001, Journal of leukocyte biology.

[63]  Tong-Yuan Yang,et al.  Aberrant in Vivo T Helper Type 2 Cell Response and Impaired Eosinophil Recruitment in Cc Chemokine Receptor 8 Knockout Mice , 2001, The Journal of experimental medicine.

[64]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[65]  Thomas Hawighorst,et al.  Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis , 2001, Nature Medicine.

[66]  Stephen Shaw,et al.  Lymph-Borne Chemokines and Other Low Molecular Weight Molecules Reach High Endothelial Venules via Specialized Conduits While a Functional Barrier Limits Access to the Lymphocyte Microenvironments in Lymph Node Cortex , 2000, The Journal of experimental medicine.

[67]  T. Schwartz,et al.  A Highly Selective Cc Chemokine Receptor (Ccr)8 Antagonist Encoded by the Poxvirus Molluscum Contagiosum , 2000, The Journal of experimental medicine.

[68]  T. Kipps,et al.  Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. , 1999, Blood.

[69]  A. Mantovani,et al.  Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. , 1998, Journal of immunology.

[70]  M. Rocchi,et al.  The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. , 1998, Journal of immunology.

[71]  Á. Zaballos,et al.  Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. , 1998, Journal of immunology.

[72]  J. Cyster,et al.  A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[73]  M. Baggiolini,et al.  Identification of CCR8, the Receptor for the Human CC Chemokine I-309* , 1997, The Journal of Biological Chemistry.

[74]  T. Bonner,et al.  Brief Definitive Report Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309 , 2022 .

[75]  J. Renauld,et al.  I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis. , 1996, Journal of immunology.

[76]  T. Schall,et al.  Biologic activities of the murine beta-chemokine TCA3. , 1994, Journal of immunology.

[77]  R. Perlis,et al.  KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. , 1993, Oncogene.

[78]  M. Krangel,et al.  The human cytokine I-309 is a monocyte chemoattractant. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[79]  J. Russo,et al.  Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. , 1990, Cancer research.

[80]  R. de Waal Malefyt,et al.  A novel polypeptide secreted by activated human T lymphocytes. , 1989, Journal of immunology.

[81]  M. Stampfer,et al.  Chromosome analyses of human mammary epithelial cells at stages of chemical-induced transformation progression to immortality. , 1989, Cancer genetics and cytogenetics.

[82]  J. Bruni,et al.  Lymph node metastasis and cell movement: ultrastructural studies on the rat 13762 mammary carcinoma and Walker carcinoma , 1985, Clinical & Experimental Metastasis.

[83]  K. Holmes,et al.  Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology. , 1983, Journal of immunology.

[84]  G Sainte-Marie,et al.  Overall architecture and pattern of lymph flow in the rat lymph node. , 1982, The American journal of anatomy.

[85]  L. Liotta,et al.  Formation of metastasis by human breast carcinoma cells (MCF-7) in nude mice. , 1980, Cancer letters.

[86]  S. Fossum,et al.  The architecture of rat lymph nodes , 1980, Anatomy and Embryology.

[87]  S. F. Gonzalez,et al.  Conduits Mediate Transport of Low-molecular-weight Antigen to Lymph Node Follicles , 2010 .

[88]  A. Ben-Baruch Organ selectivity in metastasis: regulation by chemokines and their receptors , 2007, Clinical & Experimental Metastasis.

[89]  Lisa M. Ebert,et al.  Homing and function of human skin gammadelta T cells and NK cells: relevance for tumor surveillance. , 2006, Journal of immunology.

[90]  I. Carr Lymphatic metastasis , 2004, Cancer and Metastasis Reviews.

[91]  U. Schumacher,et al.  Lectin histochemistry of the rat lymph node: visualisation of stroma, blood vessels, sinuses, and macrophages. A contribution to the concept of an immune accessory role of sinus-lining endothelia. , 2002, Acta histochemica.

[92]  C. Compton,et al.  AJCC Cancer Staging Manual , 2002, Springer New York.

[93]  C. Balch,et al.  AJCC Cancer Staging Manual. 6th ed , 2002 .

[94]  K. Schütze,et al.  Isolation by size of epithelial tumor cells : a new method for the immunomorphological and molecular characterization of circulatingtumor cells. , 2000, The American journal of pathology.