Sevoflurane verSuS propofol aneStheSia on early poStoperative cognitive function in older adultS : a randomized controlled trial

Background: postoperative cognitive dysfunction (pocd) is a common complication after surgery. The present study compared the effects of sevoflurane and propofol on POCD in old patients undergoing laparoscopic surgery under general anesthesia. Methods: Sixty patients over 65-year-old candidates for elective laparotomy were randomly assigned into two groups of anesthesia with sevoflurane or propofol. Baseline assessment of cognitive function was done 12-24 hours before surgery and the second to fourth tests were done at 6-12, 18-24, and 42-48 hours after surgery, respectively. Results: the mean age, gender and the mean time of surgery were equal in two groups. Postoperative cognitive function in sevoflurane group was significantly better than propofol group in the 6-12 (p<0.03) and 12-24 (p<0.03) hours after surgery but the assessment of the two groups in 24-48 hours after surgery showed similar conditions. Discussion: The results of this study showed that anesthesia with sevoflurane creates less cognitive disorders than anesthesia with propofol in patients without cerebrovascular complications or surgical procedures that involve the brain’s blood flow.

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