Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay.

[1]  Jerry R. Williams,et al.  Comparison of the Ames assay and the induction of sister chromatid exchanges: Results with ten pharmaceuticals and five selected agents , 1986, Cell Biology and Toxicology.

[2]  R. Snyder,et al.  Catalytic inhibition of DNA topoisomerase IIα by sodium azide , 2001 .

[3]  A. Krishnaja,et al.  Quinacrine dihydrochloride, the non-surgical female sterilant induces dicentrics, rings, and marker chromosomes in human peripheral blood lymphocytes treated in vitro: a preliminary report. , 2000, Mutation research.

[4]  R. Snyder,et al.  Use of catalytic topoisomerase II inhibitors to probe mechanisms of chemical‐induced clastogenicity in Chinese hamster V79 cells , 2000, Environmental and molecular mutagenesis.

[5]  M. Sehested,et al.  Inhibitors of topoisomerase II as pH-dependent modulators of etoposide-mediated cytotoxicity. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[6]  C. Takahashi,et al.  Effects of turmeric and its active principle, curcumin, on bleomycin-induced chromosome aberrations in Chinese hamster ovary cells , 1999 .

[7]  L. Strekowski,,et al.  Enhancement of bleomycin-induced micronucleus formation in V79 cells as a rapid and sensitive screen for non-covalent DNA-binding compounds. , 1999, Mutation research.

[8]  R. Snyder,et al.  Photogenotoxicity of fluoroquinolones in Chinese hamster V79 cells: dependency on active topoisomerase II. , 1999 .

[9]  R. Snyder A review and investigation into the mechanistic basis of the genotoxicity of antihistamines. , 1998, Mutation research.

[10]  A. Martelli,et al.  Evaluation of auramine genotoxicity in primary rat and human hepatocytes and in the intact rat. , 1998, Mutation research.

[11]  E. Zeiger,et al.  Genetic toxicity studies of 1,2,3,4-tetrahydro-9-acridinamine (tacrine). , 1997, Mutation research.

[12]  M. Sehested,et al.  DNA topoisomerase II rescue by catalytic inhibitors: a new strategy to improve the antitumor selectivity of etoposide. , 1997, Biochemical pharmacology.

[13]  E. Gocke Review of the genotoxic properties of chlorpromazine and related phenothiazines. , 1996, Mutation research.

[14]  T. Andoh,et al.  The combination of different types of antitumor topoisomerase II inhibitors, ICRF-193 and VP-16, has synergistic and antagonistic effects on cell survival, depending on treatment schedule. , 1996, Anticancer research.

[15]  H. Hansen,et al.  Targeting the cytotoxicity of topoisomerase II-directed epipodophyllotoxins to tumor cells in acidic environments. , 1994, Cancer research.

[16]  H. Hansen,et al.  Different modes of anthracycline interaction with topoisomerase II. Separate structures critical for DNA-cleavage, and for overcoming topoisomerase II-related drug resistance. , 1993, Biochemical pharmacology.

[17]  H. Zimmermann,et al.  Reinvestigation of the binding of proflavine to DNA. Is intercalation the dominant binding effect? , 1992, Cellular and Molecular Biology.

[18]  H. Hansen,et al.  Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II. , 1991, Cancer research.

[19]  M. L. Edwards,et al.  Synthesis and DNA-binding properties of polyamine analogues. , 1991, Journal of medicinal chemistry.

[20]  W. Wilson,et al.  Chemoprotection by 9-aminoacridine derivatives against the cytotoxicity of topoisomerase II-directed drugs. , 1989, European journal of cancer & clinical oncology.

[21]  A. Bodley,et al.  DNA topoisomerase II-mediated interaction of doxorubicin and daunorubicin congeners with DNA. , 1989, Cancer research.

[22]  R. Saxena,et al.  Genotoxicity evaluation of the tricyclic antidepressants amitriptyline and imipramine using human lymphocyte cultures. , 1988, Environmental and molecular mutagenesis.

[23]  T. Kurucsev,et al.  The binding of 9-aminoacridine to calf thymus DNA in aqueous solution. Electronic spectral studies. , 1985, Biophysical chemistry.

[24]  K. Kohn,et al.  Effects of the DNA intercalators 4'-(9-acridinylamino)methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage and strand passage. , 1985, Biochemistry.

[25]  G. Kupfer,et al.  Inhibition of epipodophyllotoxin cytotoxicity by interference with topoisomerase-mediated DNA cleavage. , 1985, Biochemical pharmacology.

[26]  M. Fenech,et al.  Measurement of micronuclei in lymphocytes. , 1985, Mutation research.

[27]  M. Lee,et al.  Microbial mutagenicity of isomeric two-, three-, and four-ring amino polycyclic aromatic hydrocarbons. , 1984, Environmental mutagenesis.

[28]  N. Osheroff,et al.  DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA. , 1983, The Journal of biological chemistry.

[29]  W. Denny,et al.  Potential antitumor agents. 30. Mutagenic activity of some 9-anilinoacridines: relationships between structure, mutagenic potential, and antileukemic activity. , 1979, Journal of medicinal chemistry.

[30]  W. Denny,et al.  POTENTIAL ANTITUMOR AGENTS. PART 28. DEOXYRIBONUCLEIC ACID POLYINTERCALATING AGENTS , 1978 .

[31]  W. Denny,et al.  Potenial antitumor agents. 28. Deoxyribonucleic acid polyintercalating agents. , 1978, Journal of medicinal chemistry.

[32]  A. Papaphilis,et al.  Interaction of acridines and tetrahydroacridines with DNA at low DNA/dye ratios. , 1977, Biochimica et biophysica acta.