Combining data mining and case-based reasoning for intelligent decision support for pathology ordering by general practitioners

Pathology ordering by general practitioners (GPs) is a significant contributor to rising health care costs both in Australia and worldwide. A thorough understanding of the nature and patterns of pathology utilization is an essential requirement for effective decision support for pathology ordering. In this paper a novel methodology for integrating data mining and case-based reasoning for decision support for pathology ordering is proposed. It is demonstrated how this methodology can facilitate intelligent decision support that is both patient-oriented and deeply rooted in practical peer-group evidence. Comprehensive data collected by professional pathology companies provide a system-wide profile of patient-specific pathology requests by various GPs as opposed to that limited to an individual GP practice. Using the real data provided by XYZ Pathology Company in Australia that contain more than 1.5 million records of pathology requests by general practitioners (GPs), we illustrate how knowledge extracted from these data through data mining with Kohonen's self-organizing maps constitutes the base that, with further assistance of modern data visualization tools and on-line processing interfaces, can provide "peer-group consensus" evidence support for solving new cases of pathology test ordering problem. The conclusion is that the formal methodology that integrates case-based reasoning principles which are inherently close to GPs' daily practice, and data-driven computationally intensive knowledge discovery mechanisms which can be applied to massive amounts of the pathology requests data routinely available at professional pathology companies, can facilitate more informed evidential decision making by doctors in the area of pathology ordering.

[1]  M. Pradhan,et al.  The intersection of health informatics and evidence‐based medicine: computer‐based systems to assist clinicians , 2000, The Medical journal of Australia.

[2]  Ashok N. Srivastava,et al.  Data Mining: Concepts, Models, Methods, and Algorithms , 2005, J. Comput. Inf. Sci. Eng..

[3]  M B Van der Weyden Databases and evidence‐based medicine in general practice , 1999, The Medical journal of Australia.

[4]  G D Lundberg,et al.  The need for an outcomes research agenda for clinical laboratory testing. , 1998, JAMA.

[5]  T. Kohonen,et al.  Visual Explorations in Finance with Self-Organizing Maps , 1998 .

[6]  G. Marakas Decision Support Systems in the 21st Century , 1998 .

[7]  P Axt-Adam,et al.  Influencing Behavior of Physicians Ordering Laboratory Tests: A Literature Study , 1993, Medical care.

[8]  Teuvo Kohonen,et al.  Self-organized formation of topologically correct feature maps , 2004, Biological Cybernetics.

[9]  Agnar Aamodt,et al.  Case-Based Reasoning: Foundational Issues, Methodological Variations, and System Approaches , 1994, AI Commun..

[10]  K Cox Evidence‐based medicine and everyday reality , 2001, The Medical journal of Australia.

[11]  Leonid Churilov,et al.  Uncovering the Patterns in Pathology Ordering by Australian General Practitioners: A Data Mining Perspective , 2006, Proceedings of the 39th Annual Hawaii International Conference on System Sciences (HICSS'06).

[12]  J. Ward,et al.  General practitioners' use of evidence databases , 1999, The Medical journal of Australia.

[13]  D. Mazza,et al.  Clinical practice guidelines and the computer on your desk , 2000, The Medical journal of Australia.

[14]  G D Lundberg,et al.  Why do physicians order laboratory tests? A study of laboratory test request and use patterns. , 1980, JAMA.

[15]  T. Kohonen Self-organized formation of topographically correct feature maps , 1982 .

[16]  Teuvo Kohonen,et al.  Self-Organizing Maps , 2010 .

[17]  Peter J Stuart,et al.  An interventional program for diagnostic testing in the emergency department , 2002, The Medical journal of Australia.

[18]  L. Segal,et al.  Near‐patient testing for serum cholesterol: attitudes of general practitioners and patients, appropriateness, and costs , 1998, The Medical journal of Australia.

[19]  Peter G. W. Keen,et al.  Decision support systems : an organizational perspective , 1978 .

[20]  Isabelle Bichindaritz,et al.  Case-Based Reasoning in CARE-PARTNER: Gathering Evidence for Evidence-Based Medical Practice , 1998, EWCBR.

[21]  G D Lundberg,et al.  Perseverance of laboratory test ordering: a syndrome affecting clinicians. , 1983, JAMA.

[22]  Benjamin Van Roy,et al.  Solving Data Mining Problems Through Pattern Recognition , 1997 .

[23]  David W. Aha,et al.  Feature Selection for Case-Based Classification of Cloud Types: An Empirical Comparison , 1994 .

[24]  Duane Davis,et al.  Business research for decision making , 1985 .

[25]  Michael D Ahearn,et al.  General practitioners' perceptions of the pharmaceutical decision‐support tools in their prescribing software , 2003, The Medical journal of Australia.

[26]  J. Charles,et al.  General practice activity in Australia 2002-03 , 2003 .

[27]  C. Naylor,et al.  Do we know what inappropriate laboratory utilization is? A systematic review of laboratory clinical audits. , 1998, JAMA.

[28]  M. Crook,et al.  Pathology tests: is the time for demand management ripe at last? , 2003, Journal of clinical pathology.

[29]  M H Liang,et al.  Techniques to improve physicians' use of diagnostic tests: a new conceptual framework. , 1998, JAMA.

[30]  Markus Nilsson,et al.  Advancements and Trends in Medical Case-Based Reasoning: An Overview of Systems and System Development , 2004, FLAIRS.

[31]  G. Isouard,et al.  A quality management intervention to improve clinical laboratory use in acute myocardial infarction , 1999, The Medical journal of Australia.

[32]  D. Edwards Data Mining: Concepts, Models, Methods, and Algorithms , 2003 .

[33]  Kate A. Smith,et al.  Introduction to Neural Networks and Data Mining for Business Applications , 2000 .

[34]  Teuvo Kohonen,et al.  The self-organizing map , 1990 .

[35]  Eric R. Ziegel,et al.  Mastering Data Mining , 2001, Technometrics.

[36]  Luigi Portinale,et al.  Cased-Based Reasoning for medical knowledge-based systems , 2001, Int. J. Medical Informatics.

[37]  Igor Jurisica,et al.  Data mining for case-based reasoning in high-dimensional biological domains , 2005, IEEE Transactions on Knowledge and Data Engineering.

[38]  J. H. Ward Hierarchical Grouping to Optimize an Objective Function , 1963 .

[39]  M. Weyden,et al.  Databases and evidence-based medicine in general practice. , 1999 .

[40]  W S A Smellie,et al.  Appropriateness of test use in pathology: a new era or reinventing the wheel? , 2003, Annals of clinical biochemistry.

[41]  Francisco Azuaje,et al.  Improving expression data mining through cluster validation , 2003, 4th International IEEE EMBS Special Topic Conference on Information Technology Applications in Biomedicine, 2003..

[42]  Jing Wu,et al.  Keep It Simple: A Case-Base Maintenance Policy Based on Clustering and Information Theory , 2000, Canadian Conference on AI.

[43]  R F Vining,et al.  General practitioners and pathology testing , 1998, The Medical journal of Australia.

[44]  J. Grimshaw,et al.  Effect of a practice-based strategy on test ordering performance of primary care physicians: a randomized trial. , 2003, JAMA.

[45]  M J Galloway,et al.  Benchmarking general practice use of pathology services: a model for monitoring change , 2000, Journal of clinical pathology.

[46]  R. Suganya,et al.  Data Mining Concepts and Techniques , 2010 .

[47]  W S A Smellie,et al.  Is clinical practice variability the major reason for differences in pathology requesting patterns in general practice? , 2002, Journal of clinical pathology.

[48]  Pádraig Cunningham,et al.  Automated Case Generation for Recommender Systems Using Knowledge Discovery Techniques , 2001 .

[49]  D Freedman,et al.  Methodology for constructing guidance , 2005, Journal of Clinical Pathology.

[50]  Teuvo Kohonen,et al.  Self-Organizing Maps, Second Edition , 1997, Springer Series in Information Sciences.

[51]  Leonid Churilov,et al.  A Neural Clustering Approach to Is0-Resource for Acute Healthcare in Australia , 2002 .

[52]  Janet L. Kolodner,et al.  Case-Based Reasoning , 1989, IJCAI 1989.