Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach
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R. Schiffelers | M. Symons | G. Storm | W. Gallagher | P. Vader | K. Wilschut | M. Fens | A. Byrne | E. Pieters | R. Meel | M. Jarzabek
[1] Robert Kudernatsch,et al. The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy. , 2011, Drug discovery today.
[2] T. Taxt,et al. Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma , 2011, Proceedings of the National Academy of Sciences.
[3] J. Nagy,et al. Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1. , 2011, Blood.
[4] K. Giese,et al. Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models , 2010, Clinical Cancer Research.
[5] Jeong Won Lee,et al. Targeted Gene Silencing Using RGD-Labeled Chitosan Nanoparticles , 2010, Clinical Cancer Research.
[6] G. Elia,et al. Endothelial-Rac1 Is Not Required for Tumor Angiogenesis unless αvβ3-Integrin Is Absent , 2010, PloS one.
[7] Mark E. Davis,et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles , 2010, Nature.
[8] Richard Heller,et al. Electroporation for the delivery of DNA-based vaccines and immunotherapeutics: current clinical developments. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.
[9] John M L Ebos,et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. , 2009, Cancer cell.
[10] Masahiro Inoue,et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. , 2009, Cancer cell.
[11] Anne J. Ridley,et al. Mammalian Rho GTPases: new insights into their functions from in vivo studies , 2008, Nature Reviews Molecular Cell Biology.
[12] D. Kwiatkowski,et al. Regulation of Endothelial Nitric Oxide Synthase and Postnatal Angiogenesis by Rac1 , 2008, Circulation research.
[13] Todd R. Palmby,et al. An essential role for Rac1 in endothelial cell function and vascular development , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[14] G. Davis,et al. Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling , 2008, Journal of Cell Science.
[15] J. V. van Buul,et al. VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2. , 2007, Experimental cell research.
[16] Michalis V. Karamouzis,et al. Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets , 2007, Nature Reviews Drug Discovery.
[17] B. Bryan,et al. What tangled webs they weave: Rho-GTPase control of angiogenesis , 2007, Cellular and Molecular Life Sciences.
[18] J Teissié,et al. In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery , 2007, Gene Therapy.
[19] Baolin Zhang,et al. Rac signaling in tumorigenesis and as target for anticancer drug development. , 2006, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[20] P. Opolon,et al. Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer. , 2006, Human gene therapy.
[21] X. Yao,et al. Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel‐Lindau suppression and HIF1α activation , 2006, International journal of cancer.
[22] Peter Carmeliet,et al. Angiogenesis in life, disease and medicine , 2005, Nature.
[23] Amanda Y. Chan,et al. Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion , 2005, Oncogene.
[24] J. Field,et al. Rho, Rac, Pak and angiogenesis: old roles and newly identified responsibilities in endothelial cells. , 2005, Cancer letters.
[25] Alan Hall,et al. Rho GTPases: biochemistry and biology. , 2005, Annual review of cell and developmental biology.
[26] Sofia D. Merajver,et al. Multifaceted Role of Rho Proteins in Angiogenesis , 2005, Journal of Mammary Gland Biology and Neoplasia.
[27] T. Tuschl,et al. Mechanisms of gene silencing by double-stranded RNA , 2004, Nature.
[28] J. Lacal,et al. Rho GTPases: potential candidates for anticancer therapy. , 2004, Cancer letters.
[29] A. Hall,et al. Rac regulates endothelial morphogenesis and capillary assembly. , 2002, Molecular biology of the cell.
[30] G. Davis,et al. The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices. , 2002, Journal of cell science.
[31] E. Lengyel,et al. Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b , 2000, Oncogene.
[32] B. Kaina,et al. Rho GTPases are over‐expressed in human tumors , 1999, International journal of cancer.
[33] D. Hanahan,et al. Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis , 1996, Cell.
[34] D. Scudiero,et al. New colorimetric cytotoxicity assay for anticancer-drug screening. , 1990, Journal of the National Cancer Institute.
[35] A. Hall,et al. Cell migration: Rho GTPases lead the way. , 2004, Developmental biology.