Management of Oropharyngeal Cancer in the HPV Era.

BACKGROUND Historically, oropharyngeal cancer (OPC) has been attributed to risk factors such as smoking and alcohol use. The increased incidence of OPC has been driven by human papillomavirus (HPV) infection. METHODS A search of the literature involving HPV infection and OPC was performed, along with a search of ongoing clinical trials regarding HPV-positive OPC. RESULTS This review summarizes the differences in epidemiology and prognosis of HPV-positive OPC compared with non-HPV-related OPC. It will also discuss use of de-escalating treatment to minimize toxicity while maintaining excellent outcomes. Disease management is also addressed, including prevention and follow-up recommendations for this cohort of patients. CONCLUSIONS HPV-positive OPC is a distinct disease, and efforts should be made to personalize its management. Preventive measures and vaccinations, along with de-escalation of treatment, may help optimize outcomes in this population.

[1]  U. Jeschke,et al.  Prevalence of oral HPV infection in cervical HPV positive women and their sexual partners , 2019, Archives of Gynecology and Obstetrics.

[2]  T. Strom,et al.  Determining optimal follow‐up in the management of human papillomavirus‐positive oropharyngeal cancer , 2016, Cancer.

[3]  venlig hilsen,et al.  Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck : DAHANCA 6 and 7 randomised controlled trial , 2016 .

[4]  J. Tepper,et al.  Phase 2 Trial of De-intensified Chemoradiation Therapy for Favorable-Risk Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma. , 2015, International journal of radiation oncology, biology, physics.

[5]  W. Mendenhall,et al.  External-beam radiation therapy for malignant paraganglioma of the head and neck. , 2015, American journal of otolaryngology.

[6]  Elizabeth R. Unger,et al.  Use of 9-Valent Human Papillomavirus (HPV) Vaccine: Updated HPV Vaccination Recommendations of the Advisory Committee on Immunization Practices , 2015, MMWR. Morbidity and mortality weekly report.

[7]  M. Weniger,et al.  En-bloc resection of a giant retroperitoneal lipoma: a case report and review of the literature , 2015, BMC Research Notes.

[8]  John Cho,et al.  Refining American Joint Committee on Cancer/Union for International Cancer Control TNM stage and prognostic groups for human papillomavirus-related oropharyngeal carcinomas. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  E. Pellizzer,et al.  Indications for the HPV vaccine in adolescents: a review of the literature. , 2015, Journal of infection and public health.

[10]  Jens Overgaard,et al.  Impact of HPV-associated p16-expression on radiotherapy outcome in advanced oropharynx and non-oropharynx cancer. , 2014, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[11]  V. Budach,et al.  HPV in , 2014 .

[12]  J. Lang,et al.  [Primary pelvic retroperitoneal tumors: clinical analysis of 36 cases]. , 2014, Zhonghua fu chan ke za zhi.

[13]  Sue S Yom,et al.  Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  A. Garden,et al.  Nomogram for Predicting Symptom Severity during Radiation Therapy for Head and Neck Cancer , 2014, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[15]  K. Ang,et al.  Impact of p16 status on the results of the phase III cetuximab (cet)/radiotherapy (RT). , 2014 .

[16]  R. Timmerman,et al.  A Retrospective Analysis of Tumor Volumetric Responses to Five-Fraction Stereotactic Radiotherapy for Paragangliomas of the Head and Neck (Glomus Tumors) , 2014, Stereotactic and Functional Neurosurgery.

[17]  C. Chung,et al.  Epidemiology of oral human papillomavirus infection. , 2014, Oral oncology.

[18]  H. Asamura,et al.  STAT6 Immunohistochemistry Is Helpful in the Diagnosis of Solitary Fibrous Tumors , 2014, The American journal of surgical pathology.

[19]  C. Fisher,et al.  Malignant peripheral nerve sheath tumor: pathology and genetics. , 2014, Annals of diagnostic pathology.

[20]  A. Ganti,et al.  Human papilloma virus positive oropharyngeal squamous cell carcinoma: a growing epidemic. , 2014, Cancer treatment reviews.

[21]  S. Choi,et al.  Retroperitoneal fibromatosis presenting as a presacral mass , 2014, Acta radiologica short reports.

[22]  E. King,et al.  Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer , 2013, British Journal of Cancer.

[23]  S. Saito.  Retroperitoneal Lipoma Presenting with Nutcracker-Like Phenomenon , 2013, Case reports in urology.

[24]  R. Gandour-Edwards,et al.  Definitive radiation therapy without chemotherapy for human papillomavirus–positive head and neck cancer , 2013, Head & neck.

[25]  O. Larsson,et al.  Comprehensive genetic analysis identifies a pathognomonic NAB2/STAT6 fusion gene, nonrandom secondary genomic imbalances, and a characteristic gene expression profile in solitary fibrous tumor , 2013, Genes, chromosomes & cancer.

[26]  J. Overgaard,et al.  Expression of EGFR and HPV-associated p16 in oropharyngeal carcinoma: correlation and influence on prognosis after radiotherapy in the randomized DAHANCA 5 and 7 trials. , 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[27]  W. Mendenhall,et al.  Jugular and vagal paragangliomas: Systematic study of management with surgery and radiotherapy , 2013, Head & neck.

[28]  Hong-wei Wang,et al.  Increased expression of programmed death (PD)‐1 and its ligand PD‐L1 correlates with impaired cell‐mediated immunity in high‐risk human papillomavirus‐related cervical intraepithelial neoplasia , 2013, Immunology.

[29]  D. Lowy,et al.  Reduced Prevalence of Oral Human Papillomavirus (HPV) 4 Years after Bivalent HPV Vaccination in a Randomized Clinical Trial in Costa Rica , 2013, PloS one.

[30]  F. Fang,et al.  Giant retroperitoneal lipoma in a pregnant patient , 2013, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.

[31]  W. Hwang,et al.  Evaluation of AJCC tumor staging for cutaneous squamous cell carcinoma and a proposed alternative tumor staging system. , 2013, JAMA dermatology.

[32]  D. Payne,et al.  Orthovoltage radiotherapy in the management of medial canthal basal cell carcinoma , 2013, British Journal of Ophthalmology.

[33]  J. Taube,et al.  Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. , 2013, Cancer research.

[34]  S. Demaria,et al.  Combining radiotherapy and cancer immunotherapy: a paradigm shift. , 2013, Journal of the National Cancer Institute.

[35]  Wei Xu,et al.  Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[36]  O. Dekkers,et al.  Regression and local control rates after radiotherapy for jugulotympanic paragangliomas: systematic review and meta-analysis. , 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[37]  V. Grégoire,et al.  Carotid body paragangliomas: a systematic study on management with surgery and radiotherapy , 2013, European Archives of Oto-Rhino-Laryngology.

[38]  W. Thorstad,et al.  B7-H1 Expression Model for Immune Evasion in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma , 2013, Head and Neck Pathology.

[39]  L. Murray,et al.  Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis. , 2012, Oral oncology.

[40]  L. Shih,et al.  Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report. , 2012, World journal of gastroenterology.

[41]  A. Cognetta,et al.  Superficial x-ray in the treatment of basal and squamous cell carcinomas: a viable option in select patients. , 2012, Journal of the American Academy of Dermatology.

[42]  R. West,et al.  Sox10 and S100 in the Diagnosis of Soft-tissue Neoplasms , 2012, Applied immunohistochemistry & molecular morphology : AIMM.

[43]  D. Kallogjeri,et al.  Extracapsular spread and adjuvant therapy in human papillomavirus‐related, p16‐positive oropharyngeal carcinoma , 2012, Cancer.

[44]  G. Fogarty,et al.  Cutaneous squamous cell carcinoma metastatic to parotid - analysis of prognostic factors and treatment outcome , 2012, World Journal of Surgical Oncology.

[45]  K. Ang,et al.  Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[46]  Steven D Chang,et al.  Stereotactic radiosurgery as the primary treatment for new and recurrent paragangliomas: is open surgical resection still the treatment of choice? , 2012, World neurosurgery.

[47]  C. Welz,et al.  EGFR and P-GP expression in oropharyngeal mucosa in relation to smoking. , 2012, Anticancer research.

[48]  Kevin Fung,et al.  The Role of Transoral Robotic Surgery in the Management of Oropharyngeal Cancer: A Review of the Literature , 2012, ISRN oncology.

[49]  Xianze Meng,et al.  A retroperitoneal NF1-independent malignant peripheral nerve sheath tumor with elevated serum CA125: case report and discussion , 2012, Journal of Neuro-Oncology.

[50]  Wei Xu,et al.  Outcomes of HPV-related oropharyngeal cancer patients treated by radiotherapy alone using altered fractionation. , 2012, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[51]  M. Krishna,et al.  Extremely rare giant retroperitoneal fibrolipoma: a case report. , 2012, Journal of cancer research and therapeutics.

[52]  J. Netterville,et al.  Natural history of cervical paragangliomas: outcomes of observation of 43 patients. , 2012, Archives of otolaryngology--head & neck surgery.

[53]  R. Dummer,et al.  Long-Term Recurrence Rate of Large and Difficult to Treat Cutaneous Squamous Cell Carcinomas after Superficial Radiotherapy , 2012, Dermatology.

[54]  B. Graubard,et al.  Prevalence of oral HPV infection in the United States, 2009-2010. , 2012, JAMA.

[55]  M. Chambers,et al.  A Phase II Study of Gefitinib for Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck , 2012, Clinical Cancer Research.

[56]  J. Stockman.  Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer , 2012 .

[57]  Simion I. Chiosea,et al.  Incidence of human papillomavirus in oropharyngeal squamous cell carcinomas: now and 50 years ago. , 2012, Human pathology.

[58]  Esther Kim,et al.  Human papillomavirus and rising oropharyngeal cancer incidence in the United States. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[59]  E. Franco,et al.  Epidemiology and burden of HPV infection and related diseases: implications for prevention strategies. , 2011, Preventive medicine.

[60]  J. Hornick,et al.  INI1-Deficient Tumors: Diagnostic Features and Molecular Genetics , 2011, The American journal of surgical pathology.

[61]  A. Dempsey,et al.  The role of HPV in head and neck cancer and review of the HPV vaccine. , 2011, Preventive medicine.

[62]  Jubilee Brown,et al.  Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or non-squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. , 2011, Gynecologic oncology.

[63]  L. Specht,et al.  The influence of HPV-associated p16-expression on accelerated fractionated radiotherapy in head and neck cancer: evaluation of the randomised DAHANCA 6&7 trial. , 2011, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[64]  C. Clavel,et al.  Human papillomavirus genotype distribution in oropharynx and oral cavity cancer in France--The EDiTH VI study. , 2011, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[65]  J. Shah,et al.  A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics. , 2011, Journal of the American Academy of Dermatology.

[66]  M. Birrer,et al.  Phase II study of cisplatin plus cetuximab in advanced, recurrent, and previously treated cancers of the cervix and evaluation of epidermal growth factor receptor immunohistochemical expression: a Gynecologic Oncology Group study. , 2011, Gynecologic oncology.

[67]  N J Sarlis,et al.  Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial. , 2011, Annals of oncology : official journal of the European Society for Medical Oncology.

[68]  U. Müller.  Pathological mechanisms and parent-of-origin effects in hereditary paraganglioma/pheochromocytoma (PGL/PCC) , 2011, neurogenetics.

[69]  S. Dubhashi,et al.  Giant Retroperitoneal Lipoma Presenting as Inguinal Hernia , 2011, The Indian journal of surgery.

[70]  M. Leverkus,et al.  Basal Cell Carcinoma: From the Molecular Understanding of the Pathogenesis to Targeted Therapy of Progressive Disease , 2010, Journal of skin cancer.

[71]  Steven D Chang,et al.  Radiosurgery of glomus jugulare tumors: a meta-analysis. , 2010, International journal of radiation oncology, biology, physics.

[72]  D. Heron,et al.  Linac-based stereotactic body radiation therapy for treatment of glomus jugulare tumors. , 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[73]  R. Fisher,et al.  Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[74]  Philip G. Chen,et al.  Treatment of glomus jugulare tumors with gamma knife radiosurgery , 2010, The Laryngoscope.

[75]  Jonathan R. Clark,et al.  Relationships between epidermal growth factor receptor expression and human papillomavirus status as markers of prognosis in oropharyngeal cancer. , 2010, European journal of cancer.

[76]  F. Fang,et al.  Prognostic impact of p16, p53, epidermal growth factor receptor, and human papillomavirus in oropharyngeal cancer in a betel nut-chewing area. , 2010, Archives of otolaryngology--head & neck surgery.

[77]  H. Putter,et al.  Efficacy of a hypofractionated schedule in electron beam radiotherapy for epithelial skin cancer: Analysis of 434 cases. , 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[78]  G. Ghidirim,et al.  Sporadic retroperitoneal aggressive fibromatosis: report of a case. , 2010, Zentralblatt für Chirurgie.

[79]  Miguel Giudicissi Filho,et al.  Surgical management of glomus jugulare tumors: a proposal for approach selection based on tumor relationships with the facial nerve. , 2010, Journal of neurosurgery.

[80]  S. H. van der Burg,et al.  Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. , 2009, The New England journal of medicine.

[81]  W. Mendenhall,et al.  Radiotherapy for basal cell carcinoma of the medial canthus region , 2009, The Laryngoscope.

[82]  M. Chang,et al.  Primary Retroperitoneal Malignant Gastrointestinal Stromal Tumor Mimicking Adrenal Mass. , 2009 .

[83]  A. Cognetta,et al.  Radiotherapy for cutaneous squamous and basal cell carcinomas of the head and neck , 2009, The Laryngoscope.

[84]  R. Piccinno,et al.  Radiotherapy of carcinomas of the skin overlying the cartilage of the nose: our experience in 671 lesions , 2009, Journal of the European Academy of Dermatology and Venereology : JEADV.

[85]  M. Suntharalingam,et al.  Racial Survival Disparity in Head and Neck Cancer Results from Low Prevalence of Human Papillomavirus Infection in Black Oropharyngeal Cancer Patients , 2009, Cancer Prevention Research.

[86]  H. Ozasa,et al.  Retroperitoneal lipoma arising from the urinary bladder , 2009, Rare tumors.

[87]  B. Elzey,et al.  Preclinical models of HPV+ and HPV− HNSCC in mice: An immune clearance of HPV+ HNSCC , 2009, Head & neck.

[88]  A. Folpe,et al.  TLE1 expression is not specific for synovial sarcoma: a whole section study of 163 soft tissue and bone neoplasms , 2009, Modern Pathology.

[89]  J. Pignon,et al.  Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. , 2009, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[90]  H. Yonas,et al.  Xenon techniques in predicting patients at risk for stroke after balloon test occlusion. , 2009, Neurosurgery.

[91]  Wei-Lien Wang,et al.  Clinical, Pathological, and Molecular Variables Predictive of Malignant Peripheral Nerve Sheath Tumor Outcome , 2009, Annals of surgery.

[92]  K. Pacak,et al.  Clinical aspects of SDHx-related pheochromocytoma and paraganglioma. , 2009, Endocrine-related cancer.

[93]  Y. Agrawal,et al.  Oral sexual behaviors associated with prevalent oral human papillomavirus infection. , 2009, The Journal of infectious diseases.

[94]  M. Poulsen,et al.  Radiotherapy for perineural invasion in cutaneous head and neck carcinomas: Toward a risk‐adapted treatment approach , 2009, Head & neck.

[95]  P. Johnstone,et al.  Risk of cerebrovascular events after neck and supraclavicular radiotherapy: a systematic review. , 2009, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[96]  A. Garden,et al.  Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[97]  A. Lazar,et al.  Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors. , 2008, The American journal of pathology.

[98]  M. Gillison.  Human papillomavirus-related diseases: oropharynx cancers and potential implications for adolescent HPV vaccination. , 2008, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[99]  L. Chiriboga,et al.  Sox10: A Pan-Schwannian and Melanocytic Marker , 2008, The American journal of surgical pathology.

[100]  B. Schönfisch,et al.  Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. , 2008, The Lancet. Oncology.

[101]  C. Tsien,et al.  EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[102]  M. Blute,et al.  Primary Retroperitoneal Lipoma: A Soft Tissue Pathology Heresy?: Report of a Case With Classic Histologic, Cytogenetics, and Molecular Genetic Features , 2008, The American journal of surgical pathology.

[103]  A. Bonafe,et al.  Surgical Management of Carotid Body Tumors , 2008, Annals of Surgical Oncology.

[104]  A. Cmelak,et al.  Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. , 2008, Journal of the National Cancer Institute.

[105]  Yukichi Tanaka,et al.  Diffusion-weighted imaging of retroperitoneal malignant peripheral nerve sheath tumor in a patient with neurofibromatosis type 1. , 2008, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine.

[106]  E. Taioli,et al.  Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta‐analysis , 2007, International journal of cancer.

[107]  A. Grossman,et al.  The diagnosis and management of malignant phaeochromocytoma and paraganglioma. , 2007, Endocrine-related cancer.

[108]  R. Menozzi,et al.  Absence of the Contralateral Internal Carotid Artery: A Challenge for Management of Ipsilateral Glomus Jugulare and Glomus Vagale Tumors , 2007, The Laryngoscope.

[109]  Carole Fakhry,et al.  Case-control study of human papillomavirus and oropharyngeal cancer. , 2007, The New England journal of medicine.

[110]  C. Erem,et al.  Paragangliomas of the Head and Neck , 2007, Medical Principles and Practice.

[111]  C. Ragin,et al.  The Epidemiology and Risk Factors of Head and Neck Cancer: a Focus on Human Papillomavirus , 2007, Journal of dental research.

[112]  Marc Ladanyi,et al.  TLE1 as a Diagnostic Immunohistochemical Marker for Synovial Sarcoma Emerging From Gene Expression Profiling Studies , 2007, The American journal of surgical pathology.

[113]  W. Mendenhall,et al.  Skin cancer of the head and neck with perineural invasion. , 2002, American journal of clinical oncology.

[114]  M. Falcioni,et al.  Revision glomus tumor surgery. , 2006, Otolaryngologic clinics of North America.

[115]  J. Brennan,et al.  Baroreflex Failure: A Rare Complication of Carotid Paraganglioma Surgery , 2006, The Laryngoscope.

[116]  J. Shah,et al.  Implications for clinical staging of metastatic cutaneous squamous carcinoma of the head and neck based on a multicenter study of treatment outcomes , 2006, Cancer.

[117]  S. Cass,et al.  Short-Term Tumor Control and Acute Toxicity after Stereotactic Radiosurgery for Glomus Jugulare Tumors , 2006, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[118]  Christopher U. Jones,et al.  Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. , 2006, The New England journal of medicine.

[119]  M. Thissen,et al.  Histopathological characteristics of metastasizing squamous cell carcinoma of the skin and lips , 2006, Histopathology.

[120]  Thomas Olschewski,et al.  Radiotherapy of basal cell carcinoma of the face and head: Importance of low dose per fraction on long‐term outcome , 2006, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

[121]  A. Pappo,et al.  Malignant peripheral nerve sheath tumors: The St. Jude Children's Research Hospital experience , 1995, Annals of Surgical Oncology.

[122]  Juan Hepp K,et al.  [Retroperitoneal fibromatosis: report of a case]. , 2006, Revista médica de Chile (Impresa).

[123]  A. Latos-Bieleńska,et al.  Aggressive fibromatosis (desmoid tumors): definition, occurrence, pathology, diagnostic problems, clinical behavior, genetic background. , 2006, Polish journal of pathology : official journal of the Polish Society of Pathologists.

[124]  Victor Prieto,et al.  Lymph Node Metastases from Cutaneous Squamous Cell Carcinoma of the Head and Neck , 2005, The Laryngoscope.

[125]  M. Zahurak,et al.  Tissue Distribution of Human Papillomavirus 16 DNA Integration in Patients with Tonsillar Carcinoma , 2005, Clinical Cancer Research.

[126]  S. Lippman,et al.  Mortality risk from squamous cell skin cancer. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[127]  S. Franceschi,et al.  Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review , 2005, Cancer Epidemiology Biomarkers & Prevention.

[128]  R. Piccinno,et al.  Radiotherapy of skin carcinomas of the pinna: a study of 115 lesions in 108 patients , 2004, International journal of dermatology.

[129]  T. Bley,et al.  Imaging of pheochromocytoma and paraganglioma , 2004, Familial Cancer.

[130]  W. T. Ko,et al.  Treatment options in the management of actinic keratosis. , 2004, Cutis (New York, N.Y.).

[131]  T. Kumai,et al.  Extraabdominal fibromatosis in retroperitoneal space , 2004, World journal of surgical oncology.

[132]  V. Moravan,et al.  Radiotherapy for locally advanced basal cell and squamous cell carcinomas of the skin. , 2004, International journal of radiation oncology, biology, physics.

[133]  M. Sanna,et al.  Management of Jugular Paragangliomas: The Gruppo Otologico Experience , 2004, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[134]  W. Couldwell,et al.  Comparison of radiosurgery and conventional surgery for the treatment of glomus jugulare tumors. , 2004, Neurosurgical focus.

[135]  B. Baysal.  Genomic imprinting and environment in hereditary paraganglioma , 2004, American journal of medical genetics. Part C, Seminars in medical genetics.

[136]  R. Dummer,et al.  Superficial radiotherapy for patients with basal cell carcinoma , 2003, Cancer.

[137]  D. Murawa,et al.  [Desmoids: report of cases]. , 2003, Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.

[138]  Cai Grau,et al.  Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial , 2003, The Lancet.

[139]  M. Persky,et al.  The multidisciplinary management of paragangliomas of the head and neck, Part 2. , 2003, Oncology.

[140]  M. Persky,et al.  Multidisciplinary management of paragangliomas of the head and neck, Part 1. , 2003, Oncology.

[141]  R. Maciejewski,et al.  Giant retroperitoneal lipomas--radiological case report. , 2003, Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina.

[142]  Alan D. Lopez,et al.  Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000 , 2002, BMC Cancer.

[143]  M. Byrne,et al.  Image of the month: retroperitoneal lipoma. , 2002, Archives of surgery.

[144]  G. Vespasiani,et al.  Retroperitoneal lipoma. Unusual presentation with detrusor instability. , 2002, Minerva urologica e nefrologica = The Italian journal of urology and nephrology.

[145]  C. O'brien,et al.  Significance of clinical stage, extent of surgery, and pathologic findings in metastatic cutaneous squamous carcinoma of the parotid gland , 2002, Head & neck.

[146]  D. Frank,et al.  Combined endovascular and surgical treatment of head and neck paragangliomas—A team approach , 2002, Head & neck.

[147]  R. Kline,et al.  Glomus jugulare tumor: Tumor control and complications after stereotactic radiosurgery , 2002, Head & neck.

[148]  S. Feigenberg,et al.  Radiosurgery for paraganglioma of the temporal bone , 2002, Head & neck.

[149]  L. Naldi,et al.  The epidemiology of skin cancer , 2002, The British journal of dermatology.

[150]  R. Tsang,et al.  Radiotherapy management for squamous cell carcinoma of the nasal skin: the Princess Margaret Hospital experience. , 2002, International journal of radiation oncology, biology, physics.

[151]  J. Coindre,et al.  Rearrangement involving chromosomes 1 and 8 in a retroperitoneal lipoma. , 2002, Cancer genetics and cytogenetics.

[152]  C. Antonescu,et al.  Clinicopathologic correlates of solitary fibrous tumors , 2002, Cancer.

[153]  F. Brittig,et al.  [Desmoid tumors in three patients]. , 2001, Magyar sebeszet.

[154]  N. Greenson,et al.  Appendicitis masquerading as tumor: a case of two diagnoses. , 2001, The Journal of emergency medicine.

[155]  W. Mendenhall,et al.  Radiotherapy alone for clinical T4 skin carcinoma of the head and neck with surgery reserved for salvage. , 2001, American journal of otolaryngology.

[156]  M. Lockett,et al.  Radiotherapy for epithelial skin cancer. , 2001, International journal of radiation oncology, biology, physics.

[157]  J. Netterville,et al.  Lateral Skull Base Surgery for Glomus Tumors: Long-Term Control , 2001, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[158]  S. Stringer,et al.  Definitive radiotherapy in the management of chemodectomas arising in the temporal bone, carotid body, and glomus vagale , 2001, Head & neck.

[159]  L. Pacheco-Ojeda,et al.  Malignant Carotid Body Tumors: Report of Three Cases , 2001, The Annals of otology, rhinology, and laryngology.

[160]  N. Matsubara,et al.  Multiple Tumors and a Novel E2F-4 Mutation , 2000, Digestion.

[161]  R. Tsang,et al.  Results of radiotherapy for epithelial skin cancer of the pinna: the Princess Margaret Hospital experience, 1982-1993. , 2000, International journal of radiation oncology, biology, physics.

[162]  C. Giller,et al.  Stereotastic radiosurgery for glomus jugulare tumors. , 2000, The Laryngoscope.

[163]  M. Forshaw,et al.  Rupture of an internal carotid artery aneurysm in the petrous temporal bone , 2000, British journal of neurosurgery.

[164]  G. Pendl,et al.  Gamma Knife Radiosurgery for Glomus Jugulare Tumours , 1999, Acta Neurochirurgica.

[165]  J. Shohet,et al.  Malignant Glomus Tumors , 1999, The Laryngoscope.

[166]  S. Dry,et al.  Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. , 1998, The American journal of surgical pathology.

[167]  J. Vymazal,et al.  Leksell Gamma Knife Radiosurgery of the Tumor Glomus Jugulare and Tympanicum , 1998, Stereotactic and Functional Neurosurgery.

[168]  J. Netterville,et al.  Vagal paraganglioma: a review of 46 patients treated during a 20-year period. , 1998, Archives of otolaryngology--head & neck surgery.

[169]  L. Bastholt,et al.  A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. , 1998, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[170]  J. Barr,et al.  Carotid artery balloon test occlusion: combined clinical evaluation and xenon-enhanced computed tomographic cerebral blood flow evaluation without patient transfer or balloon reinflation: technical note. , 1998, Neurosurgery.

[171]  G R Dickersin,et al.  Solitary fibrous tumor of soft tissue: a report of 15 cases, including 5 malignant examples with light microscopic, immunohistochemical, and ultrastructural data. , 1997, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[172]  A. Acheson,et al.  Pelvic lipoma causing venous obstruction syndrome. , 1997, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[173]  R. Strange,et al.  Risk Factors for Basal Cell Carcinoma in the UK: Case-Control Study in 806 Patients , 1997, Journal of the Royal Society of Medicine.

[174]  A. Aupérin,et al.  Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study. , 1997, British Journal of Cancer.

[175]  J. Earle,et al.  Stereotactic radiosurgery for glomus jugulare tumors: a preliminary report. , 1997, International journal of radiation oncology, biology, physics.

[176]  G. Viale,et al.  bcl‐2 EXPRESSION IN PLEURAL AND EXTRAPLEURAL SOLITARY FIBROUS TUMOURS , 1997, The Journal of pathology.

[177]  S. Manolidis,et al.  Lateral Skull Base Surgery: The Otology Group Experience , 1997, Skull base surgery.

[178]  T. Sano,et al.  Solitary fibrous tumor of the soft tissue. An immunohistochemical and ultrastructural study. , 1996, American journal of clinical pathology.

[179]  S. Hajdu.  Cellular schwannoma: A clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients , 1996, Cancer.

[180]  A. Budzyński,et al.  [Retroperitoneal desmoid tumor]. , 1996, Przeglad lekarski.

[181]  S. Suster,et al.  Solitary fibrous tumors of soft tissue. A clinicopathologic and immunohistochemical study of 12 cases. , 1995, The American journal of surgical pathology.

[182]  M. Mumber,et al.  Control of Advanced Chemodectomas of the Head and Neck with Irradiation , 1995, American Journal of Clinical Oncology.

[183]  J. Davelaar,et al.  Electron beam therapy is not inferior to superficial x-ray therapy in the treatment of skin carcinoma. , 1995, International journal of radiation oncology, biology, physics.

[184]  M. Miettinen,et al.  Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. , 1995, Human pathology.

[185]  A. Jackson.  Prevention, early detection and team management of skin cancer in primary care: contribution to The health of the nation objectives. , 1995, The British journal of general practice : the journal of the Royal College of General Practitioners.

[186]  J. Netterville,et al.  Carotid body tumors: A review of 30 patients with 46 tumors , 1995, The Laryngoscope.

[187]  J. M. Cole,et al.  Long‐term results of treatment for glomus jugulare and glomus vagale tumors with radiotherapy , 1994, The Laryngoscope.

[188]  M. Rijn,et al.  Expression of CD34 by solitary fibrous tumors of the pleura, mediastinum, and lung. , 1994, The American journal of surgical pathology.

[189]  D. Czarnecki,et al.  Metastases from squamous cell carcinoma of the skin in southern Australia. , 1994, Dermatology.

[190]  R. Goldwyn,et al.  Long‐Term Results of Irradiation for Basal Cell Carcinoma of the Skin of the Nose , 1994, Plastic and reconstructive surgery.

[191]  S. Mukherji,et al.  Irradiated paragangliomas of the head and neck: CT and MR appearance. , 1994, AJNR. American journal of neuroradiology.

[192]  Jackson Cg.  Neurotologic skull base surgery for glomus tumors. Diagnosis for treatment planning and treatment options. , 1993 .

[193]  M. Glasscock.  Section I. The History of Glomus Tumors: A Personal Perspective , 1993, The Laryngoscope.

[194]  J. Netterville,et al.  Section VII. Defect Reconstruction Following Neurotologic Skull Base Surgery , 1993, The Laryngoscope.

[195]  C. Perez.  Nonmelanoma cancers of the skin. , 1993, The New England journal of medicine.

[196]  J. Earle,et al.  Results of radiotherapy for chemodectomas. , 1992, Mayo Clinic proceedings.

[197]  R. Carroll,et al.  Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. , 1992, Journal of the American Academy of Dermatology.

[198]  H. Bartelink,et al.  Radiation therapy, an important mode of treatment for head and neck chemodectomas. , 1992, European journal of cancer.

[199]  W. Constable,et al.  Glomus jugulare tumors long‐term control by radiation therapy , 1992, Cancer.

[200]  S. Powell,et al.  Chemodectoma of the head and neck: results of treatment in 84 patients. , 1992, International journal of radiation oncology, biology, physics.

[201]  G. Bratthauer,et al.  Epithelioid Variant of Malignant Peripheral Nerve Sheath Tumor (Malignant Epithelioid Schwannoma) , 1991, The American journal of surgical pathology.

[202]  M. Glasscock,et al.  Cranial Nerve Preservation in Lesions of the Jugular Fossa , 1991, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[203]  P. D. de Saint-Maur.  [Cellular schwannoma: a clinicopathologic study of 29 cases]. , 1991, Annales de pathologie.

[204]  H. Makuuchi,et al.  Intra-abdominal desmoid tumors in familial polyposis coli: A case report of tumor regression by prednisolone therapy , 1991, Diseases of the colon and rectum.

[205]  D. Jones,et al.  Histologic pattern analysis of basal cell carcinoma. Study of a series of 1039 consecutive neoplasms. , 1990, Journal of the American Academy of Dermatology.

[206]  M. Rosenblum,et al.  Cellular schwannoma. A clinicopathologic study of 57 patients and 58 tumors , 1990, Cancer.

[207]  J. Boyle,et al.  Radiation therapy for paragangliomas of the temporal bone , 1990, The Laryngoscope.

[208]  L. Brady.  External irradiation of epithelial skin cancer. , 1990, International journal of radiation oncology, biology, physics.

[209]  R. Pryzant,et al.  Twenty year experience with radiation therapy for temporal bone chemodectomas. , 1989, International journal of radiation oncology, biology, physics.

[210]  G. S. Parker,et al.  Management of the Internal Carotid Artery in Surgery of the Skull Base , 1989 .

[211]  J. Lozier,et al.  Radiation therapy of skin carcinomas: results of a hypofractionated irradiation schedule in 675 cases followed more than 2 years. , 1989, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[212]  E. Russell,et al.  Superselective Embolization of Glomus Jugulare Tumors , 1988, The Annals of otology, rhinology, and laryngology.

[213]  A. Floquet,et al.  Intra and juxtavagal paraganglia: A topographical, histochemical, and ultrastructural study in the human , 1988, The Anatomical record.

[214]  B. Wen,et al.  Chemodectoma of the temporal bone: a comparison of surgical and radiotherapeutic results. , 1988, International journal of radiation oncology, biology, physics.

[215]  P. Robins,et al.  Radiotherapy of periocular basal cell carcinomas: recurrence rates and treatment with special attention to the medical canthus. , 1988, The British journal of ophthalmology.

[216]  Z. Petrovich,et al.  Treatment results and patterns of failure in 646 patients with carcinoma of the eyelids, pinna, and nose. , 1987, American journal of surgery.

[217]  S. Lo,et al.  Giant retroperitoneal pleomorphic lipoma. , 1987, The American journal of surgical pathology.

[218]  B. Scheithauer,et al.  Malignant peripheral nerve sheath tumor. An immunohistochemical study of 62 cases. , 1987, American journal of clinical pathology.

[219]  M. Filippou,et al.  The management of glomus jugulare tumours. , 1987, Clinical otolaryngology and allied sciences.

[220]  C. Mangham,et al.  Vagal body tumors: diagnosis and treatment , 1986, The Laryngoscope.

[221]  T. Shimoda,et al.  Histopathologic and immunohistochemical study of malignant tumors of peripheral nerve sheath (malignant schwannoma) , 1985 .

[222]  D. Mitchell,et al.  Chemodectomas of the neck: the response to radiotherapy , 1985, The British journal of surgery.

[223]  M. Enjoji,et al.  Malignant "triton" tumors: a clinicopathologic and immunohistochemical study of nine cases. , 1984, Human pathology.

[224]  B. Cummings,et al.  The treatment of glomus tumors in the temporal bone by megavoltage radiation , 1984, Cancer.

[225]  A. Whitton,et al.  Radiotherapy for jugulo-tympanic paragangliomas (Glomus jugulare tumours) , 1984, The Journal of Laryngology & Otology.

[226]  P. Knegt,et al.  Radiotherapy of paragangliomas. , 1984, Clinical otolaryngology and allied sciences.

[227]  G. A. Thompson,et al.  Basal and squamous cell carcinoma of the eyelids and their treatment by radiotherapy. , 1984, International journal of radiation oncology, biology, physics.

[228]  S. Weiss,et al.  Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. , 1983, Laboratory investigation; a journal of technical methods and pathology.

[229]  A. Valavanis,et al.  High-resolution CT investigation of nonchromaffin paragangliomas of the temporal bone. , 1983, AJNR. American journal of neuroradiology.

[230]  T. Nakajima,et al.  An immunoperoxidase study of S-100 protein distribution in normal and neoplastic tissues , 1982, The American journal of surgical pathology.

[231]  M. Glasscock,et al.  Glomus tumor surgery: the approach, results, and problems. , 1982, Otolaryngologic clinics of North America.

[232]  W. J. Dickens,et al.  Chemodectomas Arising in Temporal Bone Structures , 1978, The Laryngoscope.

[233]  M. Gillman,et al.  Familial carotid body tumors: Case report and epidemiologic review , 1980, Cancer.

[234]  J. Kim,et al.  Optimum dose of radiotherapy for chemodectomas of the middle ear. , 1980, International journal of radiation oncology, biology, physics.

[235]  M. Glasscock,et al.  Glomus tumors: diagnosis and surgery. , 1979, Revue de laryngologie - otologie - rhinologie.

[236]  M. Gado,et al.  Glomus Jugulare and Vagale , 1978, The Annals of otology, rhinology, and laryngology.

[237]  J. Blasko,et al.  The role of radiation therapy in the treatment of glomus jugulare tumors. , 1977, Cancer.

[238]  J. Henk,et al.  Glomus jugulare tumours in South Wales--a twenty-year review. , 1978, Clinical radiology.

[239]  G. Gardner,et al.  Combined approach surgery for removal of glomus jugulare tumors , 1977, The Laryngoscope.

[240]  M. Mcmaster,et al.  Hemangiopericytoma: A clinicopathologic study and long‐term followup of 60 patients , 1975 .

[241]  E. Montague,et al.  Chemodectomas involving the temporal bone. , 1975, Radiology.

[242]  C. Perez,et al.  Glomus jugulare tumors: effects of radiotherapy. , 1975, Cancer.

[243]  M. Glasscock,et al.  Glomus tumors: diagnosis and treatment , 1974, The Laryngoscope.

[244]  S. Silverstone.  Radiation therapy of glomus jugulare tumors. , 1973, Archives of otolaryngology.

[245]  Y. Maruyama.  Radiotherapy of tympanojugular chemodectomas. , 1972, Radiology.

[246]  W. House,et al.  Glomus jugulare tumors: effect of irradiation. , 1972, Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology.

[247]  I. Homorodeanu,et al.  [A giant retroperitoneal lipoma: case report]. , 1969, Acta gastro-enterologica Belgica.

[248]  H. Rosenwasser.  Current management glomus jugulare tumors. , 1968, The Annals of otology, rhinology, and laryngology.

[249]  R. Siekert,et al.  Chemodectomas of the glomus jugulare tumors , 1967, The Laryngoscope.

[250]  I. Lampe,et al.  The role of radiation therapy in the treatment of chemodectomas of the glomus jugulare , 1965, The Laryngoscope.

[251]  P. J. Vanmiert.  THE TREATMENT OF CHEMODECTOMAS BY RADIOTHERAPY. , 1964, Proceedings of the Royal Society of Medicine.

[252]  B. Alford,et al.  A comprehensive study of tumors of the glomus jugulare. , 1962, The Laryngoscope.

[253]  E. Burke,et al.  Glomus jugulare tumors , 1952, The Laryngoscope.