Dim light melatonin onset and circadian temperature during a constant routine in hypersomnic winter depression

The onset of melatonin secretion under dim light conditions (DLMO) and the circadian temperature rhythm during a constant routine were assessed in 6 female controls and 6 female patients with winter depression (seasonal affective disorder, SAD) before and after bright light treatment. After sleep was standardized for 6 days, the subjects were sleep‐deprived and at bedrest for 27 h while core temperature and evening melatonin levels were determined. The DLMO of the SAD patients was phase‐delayed compared with controls (2310 vs 2138); with bright light treatment, the DLMO advanced (2310 to 2135). The minimum of the fitted rectal temperature rhythm was phase‐delayed in the SAD group compared with the controls (0542 vs 0316); with bright light treatment, the minimum advanced (0542 vs 0336).

[1]  D A Newsome,et al.  Light suppresses melatonin secretion in humans. , 1980, Science.

[2]  T. Wehr,et al.  Effects of light treatment on core body temperature in seasonal affective disorder , 1990, Biological Psychiatry.

[3]  C A Czeisler,et al.  Light exposure induces equivalent phase shifts of the endogenous circadian rhythms of circulating plasma melatonin and core body temperature in men. , 1991, The Journal of clinical endocrinology and metabolism.

[4]  A. Lewy,et al.  The dim light melatonin onset as a marker for circadian phase position. , 1989, Chronobiology international.

[5]  F. Goodwin,et al.  Negative effects of melatonin on depression. , 1976, The American journal of psychiatry.

[6]  F. Goodwin,et al.  Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. , 1984, Archives of general psychiatry.

[7]  S. Dager,et al.  Morning or evening bright light treatment of winter depression? The significance of hypersomnia , 1991, Biological Psychiatry.

[8]  C. M. Singer,et al.  Treating phase typed chronobiologic sleep and mood disorders using appropriately timed bright artificial light. , 1985, Psychopharmacology bulletin.

[9]  J. Feighner,et al.  Diagnostic criteria for use in psychiatric research. , 1972, Archives of general psychiatry.

[10]  Lewy Aj,et al.  Assessment and treatment of chronobiologic disorders using plasma melatonin levels and bright light exposure: the clock-gate model and the phase response curve. , 1984 .

[11]  J. Horne,et al.  A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. , 1976, International journal of chronobiology.

[12]  A. Lewy,et al.  Antidepressant and circadian phase-shifting effects of light. , 1987, Science.

[13]  A J Lagomarsino,et al.  [Seasonal affective disorders]. , 1988, Acta psiquiatrica y psicologica de America latina.

[14]  M. Hamilton,et al.  Development of a rating scale for primary depressive illness. , 1967, The British journal of social and clinical psychology.

[15]  S. Markey,et al.  Analysis of melatonin in human plasma by gas chromatography negative chemical ionization mass spectrometry. , 1978, Science.

[16]  J. Waterhouse,et al.  Adaptation to abrupt time shifts of the oscillator(s) controlling human circadian rhythms. , 1978, The Journal of physiology.

[17]  J. Waterhouse,et al.  Masking in humans: the problem and some attempts to solve it. , 1989, Chronobiology international.

[18]  J. Mooney,et al.  Biologic rhythm disorders, depression, and phototherapy. A new hypothesis. , 1987, The Psychiatric clinics of North America.

[19]  D. M. White,et al.  Morning vs evening light treatment for winter depression. Evidence that the therapeutic effects of light are mediated by circadian phase shifts. , 1990, Archives of general psychiatry.

[20]  D. Dawson,et al.  Sleep-onset insomniacs have delayed temperature rhythms. , 1990, Sleep.

[21]  A. Lewy,et al.  Assessment and treatment of chronobiologic disorders using plasma melatonin levels and bright light exposure: the clock-gate model and the phase response curve. , 1984, Psychopharmacology bulletin.

[22]  R. Kronauer,et al.  Bright light induction of strong (type 0) resetting of the human circadian pacemaker. , 1989, Science.

[23]  R. Strassman,et al.  Elevated rectal temperature produced by all-night bright light is reversed by melatonin infusion in men. , 1991, Journal of applied physiology.

[24]  J. Brunzell,et al.  Weight loss leads to a marked decrease in nonresting energy expenditure in ambulatory human subjects. , 1988, Metabolism: clinical and experimental.