Understanding how combinations of HLA and KIR genes influence disease

Combinations of HLA and killer cell immunoglobulin–like receptor (KIR) genes have been associated with diseases as diverse as autoimmunity, viral infections, reproductive failure, and now cancer. Much as early observations of disease associations with HLA polymorphism preceded a detailed knowledge of HLA recognition by T cell receptors, the recently reported disease associations with HLA–KIR gene combinations beg for a better understanding of the underlying mechanisms.

[1]  S. Rowland-Jones,et al.  Recognition of HLA‐A3 and HLA‐A11 by KIR3DL2 is peptide‐specific , 2004, European journal of immunology.

[2]  C. Woodworth.  HPV innate immunity. , 2002, Frontiers in bioscience : a journal and virtual library.

[3]  G. Gao,et al.  Killer Cell Immunoglobulin Receptors and T Cell Receptors Bind Peptide-Major Histocompatibility Complex Class I with Distinct Thermodynamic and Kinetic Properties* , 1999, The Journal of Biological Chemistry.

[4]  Jeffrey C. Boyington,et al.  Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand , 2000, Nature.

[5]  Diana Brahams,et al.  Medicine and the Law , 1983, The Lancet.

[6]  Daniel J. Schaid,et al.  Major Histocompatibility Complex Class I–Recognizing Receptors Are Disease Risk Genes in Rheumatoid Arthritis , 2001, The Journal of experimental medicine.

[7]  J. Strominger,et al.  Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors. , 1998, Immunity.

[8]  Milena Ivanova,et al.  Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals , 2005, Cancer Immunology, Immunotherapy.

[9]  D. Fremont,et al.  Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors , 2003, Nature Immunology.

[10]  R. Biassoni,et al.  Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA‐Cw4 molecules , 1997, European journal of immunology.

[11]  Eric O Long,et al.  Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. , 1998, Journal of immunology.

[12]  Eric O Long,et al.  HLA class I recognition by killer cell Ig-like receptors. , 2000, Seminars in immunology.

[13]  É. Vivier,et al.  Selective Activation of the c-Jun NH2-terminal Protein Kinase Signaling Pathway by Stimulatory KIR in the Absence of KARAP/DAP12 in CD4+ T Cells , 2003, The Journal of experimental medicine.

[14]  J. Strominger,et al.  The role of zinc in the binding of killer cell Ig-like receptors to class I MHC proteins. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[15]  M. Mańczak,et al.  Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris. , 2004, Human immunology.

[16]  H. Mcdevitt,et al.  HL-A, immune-response genes, and disease. , 1974, Lancet.

[17]  Keith Hoots,et al.  Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS , 2002, Nature Genetics.

[18]  D. Fremont,et al.  Recognition of a virus-encoded ligand by a natural killer cell activation receptor , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Andrew Glass,et al.  Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci , 2005 .

[20]  Lewis L Lanier,et al.  NK cell recognition. , 2005, Annual review of immunology.

[21]  M. Carrington,et al.  Cutting Edge: Heterozygote Advantage in Autoimmune Disease: Hierarchy of Protection/Susceptibility Conferred by HLA and Killer Ig-Like Receptor Combinations in Psoriatic Arthritis1 , 2004, The Journal of Immunology.

[22]  Salim I. Khakoo,et al.  HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection , 2004, Science.

[23]  M. Carrington,et al.  Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success , 2004, The Journal of experimental medicine.

[24]  P Parham,et al.  Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. , 1997, Immunity.

[25]  L. Lanier,et al.  Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors , 2002, Science.

[26]  P. Parham.  MHC class I molecules and kirs in human history, health and survival , 2005, Nature Reviews Immunology.

[27]  Eric Mickelson,et al.  Killer Ig-Like Receptor Haplotype Analysis by Gene Content: Evidence for Genomic Diversity with a Minimum of Six Basic Framework Haplotypes, Each with Multiple Subsets1 , 2002, The Journal of Immunology.

[28]  S. Gasser,et al.  Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[29]  B. Koeleman,et al.  KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects. , 2003, Diabetes.

[30]  Peter Parham,et al.  KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. , 2002, Annual review of immunology.

[31]  L. Lanier,et al.  A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition , 2002, The Journal of experimental medicine.

[32]  Eric O Long,et al.  Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells. , 1998, Journal of immunology.

[33]  H. Achdout,et al.  MHC Class I-Independent Recognition of NK-Activating Receptor KIR2DS41 , 2004, The Journal of Immunology.