Rectal Administration of Acetylsalicylic Acid (ASA) in Rheumatoid Arthritis.

SummaryFifteen patients with rheumatoid arthritis received 0.5 to 1.0 grams of ASA rectally in an Imhausen-W base. After 15 minutes, definite levels of ASA could be observed in the serum. Maximum serum levels were obtained in 2 to 3 hours, the mean values being 2.81 mg% with 0.5 gm., 3.42 mg% with 0.75 gm., and 3.5 mg% with 1.0 gm. Clinical effect was noted as an average in 1 to 1 1/2 hours. Subjective side effects occurred in two patients out of six who received 0.75 gm. of ASA twice daily for one week. Slight signs of irritation could be verified. Mucosal biopsies from the rectum were taken during endoscopy prior to and after the one-week course on ASA. No serious histological damages caused by ASA could be demonstrated. Benzidine and guaiac tests were followed during the whole time and were always negative. ASA can be given rectally to rheumatic patients, temporarily at least, if oral administration is contra-indicated.

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