Back to the basics of time-of-flight secondary ion mass spectrometry data analysis of bio-related samples. II. Data processing and display.

This is the second half of a two-part Tutorial on the basics of the time-of-flight secondary ion mass spectrometry (ToF-SIMS) analysis of bio-related samples. Part I of this Tutorial series covers planning for a ToF-SIMS experiment, preparing and shipping samples, and collecting ToF-SIMS data. This Tutorial aims at helping the ToF-SIMS user to process, display, and interpret ToF-SIMS data. ToF-SIMS provides detailed chemical information about surfaces but comes with a steep learning. The purpose of this Tutorial is to provide the reader with a solid foundation in the ToF-SIMS data analysis.

[1]  C. Nicora,et al.  Exploiting the semi-destructive nature of GCIB-ToF-SIMS imaging for simultaneous localization and confident lipid annotations. , 2019, Analytical chemistry.

[2]  N. Winograd.  Gas Cluster Ion Beams for Secondary Ion Mass Spectrometry. , 2018, Annual review of analytical chemistry.

[3]  Andrew L. Hook,et al.  ToF‐SIMS analysis of a polymer microarray composed of poly(meth)acrylates with C6 derivative pendant groups , 2016, Surface and interface analysis : SIA.

[4]  H. Nie.  Negative hydrocarbon species C2nH−: How useful can they be? , 2016 .

[5]  C. Chan,et al.  Clean graphene surface through high temperature annealing , 2015 .

[6]  M. Alexander,et al.  Measuring Compositions in Organic Depth Profiling: Results from a VAMAS Interlaboratory Study. , 2015, The journal of physical chemistry. B.

[7]  Tina B. Angerer,et al.  Improved molecular imaging in rodent brain with time-of-flight-secondary ion mass spectrometry using gas cluster ion beams and reactive vapor exposure. , 2015, Analytical chemistry.

[8]  M. Alexander,et al.  Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption. , 2015, Biointerphases.

[9]  Josephine Bunch,et al.  Optimisation of colour schemes to accurately display mass spectrometry imaging data based on human colour perception , 2015, Analytical and Bioanalytical Chemistry.

[10]  M. Alexander,et al.  3D ToF-SIMS imaging of polymer multilayer films using argon cluster sputter depth profiling. , 2015, ACS applied materials & interfaces.

[11]  C. Chan,et al.  Polymer surface structures determined using ToF-SIMS , 2014 .

[12]  Vincent S. Smentkowski,et al.  Surface Analysis and Techniques in Biology , 2014, Springer International Publishing.

[13]  D. Castner,et al.  Probing the orientation of electrostatically immobilized cytochrome C by time of flight secondary ion mass spectrometry and sum frequency generation spectroscopy , 2013, Biointerphases.

[14]  Daniel J. Graham,et al.  Multivariate Analysis of ToF-SIMS Data from Multicomponent Systems: The Why, When, and How , 2012, Biointerphases.

[15]  J. Lefman,et al.  Automated correlation and classification of secondary ion mass spectrometry images using a k-means cluster method. , 2012, The Analyst.

[16]  D. Castner,et al.  Probing the orientation of electrostatically immobilized Protein G B1 by time-of-flight secondary ion spectrometry, sum frequency generation, and near-edge X-ray adsorption fine structure spectroscopy. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[17]  N. Winograd,et al.  Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS). , 2011, Biochimica et biophysica acta.

[18]  N. Winograd,et al.  Label free biochemical 2D and 3D imaging using secondary ion mass spectrometry. , 2011, Current opinion in chemical biology.

[19]  D. Grainger,et al.  Immobilized antibody orientation analysis using secondary ion mass spectrometry and fluorescence imaging of affinity-generated patterns. , 2010, Analytical chemistry.

[20]  D. Castner,et al.  XPS and ToF-SIMS investigation of alpha-helical and beta-strand peptide adsorption onto SAMs. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[21]  Ji-won Park,et al.  Multivariate analysis of ToF‐SIMS data for biological applications , 2009 .

[22]  Ian S. Gilmore,et al.  Multivariate image analysis strategies for ToF‐SIMS images with topography , 2009 .

[23]  J. Vickerman.  Molecular Surface Mass Spectrometry by SIMS , 2009 .

[24]  Alain Brunelle,et al.  Lipid imaging with cluster time-of-flight secondary ion mass spectrometry , 2009, Analytical and bioanalytical chemistry.

[25]  W. Boireau,et al.  TOF-SIMS structural characterization of self-assembly monolayer of cytochrome b5 onto gold substrate. , 2008, 1001.2691.

[26]  M. Alexander,et al.  TOF-SIMS analysis of a 576 micropatterned copolymer array to reveal surface moieties that control wettability. , 2008, Analytical chemistry.

[27]  David G. Castner,et al.  Multivariate analysis strategies for processing ToF-SIMS images of biomaterials. , 2007, Biomaterials.

[28]  Daniel J. Graham,et al.  Simplifying the interpretation of ToF-SIMS spectra and images using careful application of multivariate analysis , 2006 .

[29]  Daniel J. Graham,et al.  Information from complexity: Challenges of TOF-SIMS data interpretation , 2006 .

[30]  R. Goodacre,et al.  ToF-SIMS studies of Bacillus using multivariate analysis with possible identification and taxonomic applications , 2006, Applied Surface Science.

[31]  T. Kishimoto,et al.  A new analysis of the depolymerized fragments of lignin polymer using ToF-SIMS. , 2005, Biomacromolecules.

[32]  D. Castner,et al.  Evidence of impurities in thiolated single-stranded DNA oligomers and their effect on DNA self-assembly on gold. , 2005, Langmuir : the ACS journal of surfaces and colloids.

[33]  Julian Morris,et al.  Curve resolution for multivariate images with applications to TOF-SIMS and Raman , 2004 .

[34]  P. Bertrand,et al.  Emission processes of molecule-metal cluster ions from self-assembled monolayers of octanethiols on gold and silver , 2004 .

[35]  D. Castner,et al.  Analysis of adsorbed proteins by static time-of-flight secondary ion mass spectrometry , 2004 .

[36]  Michael R. Keenan,et al.  Accounting for Poisson noise in the multivariate analysis of ToF‐SIMS spectrum images , 2004 .

[37]  Shaoyi Jiang,et al.  Probing the orientation of surface-immobilized immunoglobulin G by time-of-flight secondary ion mass spectrometry. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[38]  D. Castner,et al.  Characterization of the structure of binary and ternary adsorbed protein films using electron spectroscopy for chemical analysis, time-of-flight secondary ion mass spectrometry, and radiolabeling , 2003 .

[39]  B. Ratner,et al.  Multivariate Analysis of TOF-SIMS Spectra from Dodecanethiol SAM Assembly on Gold: Spectral Interpretation and TOF-SIMS Fragmentation Processes , 2002 .

[40]  David G Castner,et al.  Interpretation of static time-of-flight secondary ion mass spectra of adsorbed protein films by multivariate pattern recognition. , 2002, Analytical chemistry.

[41]  D. Castner,et al.  Analysis of Poly(amino acids) by Static Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) , 2001 .

[42]  A. Ewing,et al.  Atomic and molecular imaging at the single-cell level with TOF-SIMS. , 1997, Analytical chemistry.

[43]  D. Landolt,et al.  Surface analysis of polyethyleneterephthalate by ESCA and TOF-SIMS , 1997 .

[44]  A. Chilkoti,et al.  Relationship between Surface Chemistry and Endothelial Cell Growth: Partial Least-Squares Regression of the Static Secondary Ion Mass Spectra of Oxygen-Containing Plasma-Deposited Films , 1995 .

[45]  Lucinda R. Hittle,et al.  Investigation of intramolecular hydrogen-deuterium exchange in the time-of-flight secondary-ion mass spectra of polystyrene , 1995 .

[46]  B. Ratner,et al.  Static secondary ion mass spectrometry of adsorbed proteins. , 1993, Analytical chemistry.

[47]  A. Benninghoven,et al.  High-resolution TOF-SIMS studies of substituted polystyrenes , 1992 .