Electrochemotherapy with Bleomycin in the Treatment of Hypernephroma Metastasis: Case Report and Literature Review

A metastasis of hypernephroma was treated by electrochemotherapy with bleomycin. Electrochemotherapy consists of chemotherapy followed by local application of electric pulses to the tumor in order to increase drug delivery to the cells. In the course of a four-week treatment period, the subcutaneous metastasis of the hypernephroma was treated with three sessions of electrochemotherapy, each consisting of 9–10 runs of 8 electric pulses, 10 min after intravenous injection of bleomycin. This treatment resulted in stabilization of the tumor volume for 12 months, whereas the subcutaneous metastasis next to the electrochemotherapy-treated one that did not receive electric pulses progressed immediately.

[1]  Franci Demsar,et al.  CONTRAST ENHANCED MRI ASSESSMENT OF TUMOR BLOOD VOLUME AFTER APPLICATION OF ELECTRIC PULSES , 1998 .

[2]  S. Orlowski,et al.  Mechanisms of electrochemotherapy. , 1999, Advanced drug delivery reviews.

[3]  D. Petrylak,et al.  Chemotherapy for advanced renal-cell carcinoma: 1983-1993. , 1995, Seminars in oncology.

[4]  D. Miklavčič,et al.  © 1999 Cancer Research Campaign Article no. bjoc.1998.0222 , 2022 .

[5]  M Cemazar,et al.  Tumour blood flow changes induced by application of electric pulses. , 1999, European journal of cancer.

[6]  L. Mir,et al.  Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: direct access to the cytosol. , 1988, Experimental cell research.

[7]  L. Mir,et al.  Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. , 1991, European journal of cancer.

[8]  M. Jaroszeski,et al.  Clinical applications of electrochemotherapy. , 1999, Advanced drug delivery reviews.

[9]  D. Miklavčič,et al.  Electrochemotherapy with bleomycin. The first clinical experience in malignant melanoma patients , 1995 .

[10]  D. Miklavcic,et al.  Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. , 1998, British Journal of Cancer.

[11]  D Miklavcic,et al.  Electrochemotherapy with cisplatin: potentiation of local cisplatin antitumour effectiveness by application of electric pulses in cancer patients. , 1998, European journal of cancer.

[12]  W. Panje,et al.  Electroporation Therapy of Head and Neck Cancer , 1998, Annals of Otology, Rhinology and Laryngology.

[13]  D Miklavcic,et al.  Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice. , 1995, Cancer research.

[14]  D Miklavcic,et al.  Tumor blood flow modifying effect of electrochemotherapy with bleomycin. , 1999, Anticancer research.

[15]  T Nakada,et al.  Successful treatment of metastatic skin lesions with electrochemotherapy. , 1998, The Journal of urology.

[16]  D Miklavcic,et al.  Electrochemotherapy with cisplatin: clinical experience in malignant melanoma patients. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[17]  L. Mir,et al.  Very high cytotoxicity of bleomycin introduced into the cytosol of cells in culture. , 1991, Biochemical pharmacology.