The Effect of Zhejiang Fritillaria Thunbergii Against Immunological CP/CPPS

Objective:To develop a mice model of nonbacterial chronic prostatitis.To explore the treatment of chronic prostatitis Pui the mechanism to evaluate its clinical efficacy prostatitis.Methods:Aged Sprague-Dawley mices were castrated and injected Aluminum Hydroxide immune file.(0.5 mg/day,s.C.)for 30days.Prostates were harvested after 30 days injection.Prostatic tissue was examined histologically for degree of inflammation.Pui to observe the impact of pathological model.Results: Different degree of inflammation and lymphocytic infiltration was found in prostate after injection.Endovascular secretions significantly increased.Interstitial infiltration of inflammatory cells was decreased fibrosis also decreased noticeably.Compared with model group,there was a significant difference(P0.05).Most animals laminin(LN) and fibronectin(FN) was weakly positive,a few animals positive linear gland in the basement membrane,interstitial and perivascular Flake point spread in Leydig,Compared with model group,there was a significant difference(P0.05).Conclusion:Injection of estradiol benzoate can induce prostatic inflammation similar to clinical nonbacterial chronic prostatitis and it will be a good way to found an animal prostatitis mode1.Big Shell is reducing pathological model inflammatory response,reducing the degree of fibrosis.