Cerebellar connections with the motor cortex and the arcuate premotor area: An analysis employing retrograde transneuronal transport of WGA‐HRP

We have employed transneuronal transport to examine the anatomical relationships between the deep cerebellar nuclei and 2 cortical motor areas: the primary motor cortex and the arcuate premotor area (APA). In the same animals, we have also examined the patterns of labeling in the thalamus and the red nucleus to provide evidence for the potential routes of transneuronal transport to the cerebellum.

[1]  G. Holmes THE CEREBELLUM OF MAN , 1939 .

[2]  J. Olszewski The Thalamus of the Macaca Mulatta: An Atlas for Use with the Stereotaxic Instrument , 1952 .

[3]  Ray S. Snider,et al.  A stereotaxic atlas of the monkey brain : (Macaca mulatta) , 1961 .

[4]  D. G. Lawrence,et al.  Cortical projections to the red nucleus and the brain stem in the Rhesus monkey. , 1967, Brain research.

[5]  W. T. Thach,et al.  Motor mechanisms of the CNS: cerebrocerebellar interrelations. , 1969, Annual review of physiology.

[6]  C. W. Cooper,et al.  The cerebellar nuclei of Macaca mulatta: A morphological study , 1970, The Journal of comparative neurology.

[7]  W. Mehler Idea of a new anatomy of the thalamus. , 1971, Journal of psychiatric research.

[8]  J. Jansen,et al.  The Comparative Anatomy and Histology of the Cerebellum: The Human Cerebellum, Cerebellar Connections, and Cerebellar Cortex , 1972 .

[9]  B. Flumerfelt,et al.  Distinct projections to the red nucleus from the dentate and interposed nuclei in the monkey. , 1973, Brain research.

[10]  H. Kuypers,et al.  Intrahemispheric cortical connexions and visual guidance of hand and finger movements in the rhusus monkey. , 1975, Brain : a journal of neurology.

[11]  P. Strick Anatomical analysis of ventrolateral thalamic input to primate motor cortex. , 1976, Journal of neurophysiology.

[12]  D. Robinson,et al.  Some ipsilateral projections to areas PF and PG of the inferior parietal lobule in monkeys , 1977, Neuroscience Letters.

[13]  M B Carpenter,et al.  Fastigial efferent projections in the monkey: An autoradiographic study , 1977, The Journal of comparative neurology.

[14]  V. Chan‐Palay Cerebellar Dentate Nucleus: Organization, Cytology and Transmitters , 1977 .

[15]  J R Bloedel,et al.  Organizational features of the cat and monkey cerebellar nucleocortical projection , 1978, The Journal of comparative neurology.

[16]  M. Mesulam,et al.  THE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY , 2005 .

[17]  H. Künzle An autoradiographic analysis of the efferent connections from premotor and adjacent prefrontal regions (areas 6 and 9) in macaca fascicularis. , 1978, Brain, behavior and evolution.

[18]  Peter L. Strick,et al.  Multiple representation in the primate motor cortex , 1978, Brain Research.

[19]  E. G. Jones,et al.  Differential thalamic relationships of sensory‐motor and parietal cortical fields in monkeys , 1979, The Journal of comparative neurology.

[20]  P. Strick,et al.  Frontal lobe inputs to primate motor cortex: evidence for four somatotopically organized ‘premotor’ areas , 1979, Brain Research.

[21]  G. B. Stanton Topographical organization of ascending cerebellar projections from the dentate and interposed nuclei in Macaca mulatta: An anterograde degeneration study , 1980, The Journal of comparative neurology.

[22]  G. Rizzolatti,et al.  Afferent properties of periarcuate neurons in macaque monkeys. I. Somatosensory responses , 1981, Behavioural Brain Research.

[23]  K. Kalil Projections of the cerebellar and dorsal column nuclei upon the thalamus of the rhesus monkey , 1981, The Journal of comparative neurology.

[24]  G. Rizzolatti,et al.  Afferent properties of periarcuate neurons in macaque monkeys. II. Visual responses , 1981, Behavioural Brain Research.

[25]  Marc H. Schieber,et al.  Cerebellar Output: Body Maps and Muscle Spindles , 1982 .

[26]  J. B. Preston,et al.  Two representations of the hand in area 4 of a primate. II. Somatosensory input organization. , 1982, Journal of neurophysiology.

[27]  J. D. Coulter,et al.  Axonal and transneuronal transport of wheat germ agglutinin demonstrated by immunocytochemistry , 1982, Brain Research.

[28]  J. B. Preston,et al.  Two representations of the hand in area 4 of a primate. I. Motor output organization. , 1982, Journal of neurophysiology.

[29]  M. Mesulam,et al.  Tracing Neural Connections with Horseradish Peroxidase , 1982 .

[30]  W. T. Thach,et al.  Anatomical evidence for segregated focal groupings of efferent cells and their terminal ramifications in the cerebellothalamic pathway of the monkey , 1983, Brain Research Reviews.

[31]  K. Sasaki,et al.  HRP studies on thalamocortical neurons related to the cerebellocerebral projection in the monkey , 1983, Brain Research.

[32]  W. T. Thach,et al.  Distribution of cerebellar terminations and their relation to other afferent terminations in the ventral lateral thalamic region of the monkey , 1983, Brain Research Reviews.

[33]  W. T. Thach,et al.  Cytoarchitectonic delineation of the ventral lateral thalamic region in the monkey , 1983, Brain Research Reviews.

[34]  W. T. Thach,et al.  Brainstem and spinal projections of the deep cerebellar nuclei in the monkey, with observations on the brainstem projections of the dorsal column nuclei , 1983, Brain Research Reviews.

[35]  G. Rizzolatti,et al.  Deficits in attention and movement following the removal of postarcuate (area 6) and prearcuate (area 8) cortex in macaque monkeys. , 1983, Brain : a journal of neurology.

[36]  D. Tolbert,et al.  Transient cerebrocerebellar projections in kittens: Postnatal development and topography , 1983, The Journal of comparative neurology.

[37]  T. Kaneko,et al.  An anterograde-retrograde transneuronal transport of conjugates of wheat germ agglutinin with horseradish peroxidase (WGA-HRP): labeling of neurons in the reticular nucleus of the thalamus with WGA-HRP injected into the posterior column nuclei in the cat , 1984, Brain Research.

[38]  P. Strick,et al.  The origin of thalamic inputs to the arcuate premotor and supplementary motor areas , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[39]  H. Hultborn,et al.  Labelling of interneurones by retrograde transsynaptic transport of horseradish peroxidase from motoneurones in rats and cats , 1984, Neuroscience Letters.

[40]  D. Humphrey,et al.  Sizes, laminar and topographic origins of cortical projections to the major divisions of the red nucleus in the monkey , 1984, The Journal of comparative neurology.

[41]  J. C. Houk,et al.  A sensitive low artifact TMB procedure for the demonstration of WGA-HRP in the CNS , 1984, Brain Research.

[42]  Masao Ito The Cerebellum And Neural Control , 1984 .

[43]  D. Tolbert,et al.  The transience of cerebrocerebellar projections is due to selective elimination of axon collaterals and not neuronal death. , 1984, Brain research.

[44]  S. P. Wise,et al.  Set-related neuronal activity in the premotor cortex of rhesus monkeys: effects of changes in motor set , 1985, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[45]  E. Jankowska Further indications for enhancement of retrograde transneuronal transport of WGA-HRP by synaptic activity , 1985, Brain Research.

[46]  S. Wise The primate premotor cortex: past, present, and preparatory. , 1985, Annual review of neuroscience.

[47]  H J Ralston,et al.  Light and electron microscopic evidence of transneuronal labeling with WGA‐HRP to trace somatosensory pathways to the thalamus , 1985, The Journal of comparative neurology.

[48]  Peter L. Strick,et al.  How do the basal ganglia and cerebellum gain access to the cortical motor areas? , 1985, Behavioural Brain Research.

[49]  R. Lemon,et al.  The involvement of monkey premotor cortex neurones in preparation of visually cued arm movements , 1985, Behavioural Brain Research.

[50]  D. Pandya,et al.  Corticothalamic connections of the posterior parietal cortex in the rhesus monkey , 1985, The Journal of comparative neurology.

[51]  Y. Lamarre,et al.  Activity of dentate neurons during arm movements triggered by visual, auditory, and somesthetic stimuli in the monkey. , 1986, Journal of neurophysiology.

[52]  J. Houk,et al.  Functional and anatomic differentiation between parvicellular and magnocellular regions of red nucleus in the monkey , 1986, Brain Research.

[53]  A. L. Leiner,et al.  Does the cerebellum contribute to mental skills? , 1986, Behavioral neuroscience.

[54]  B. Alstermark,et al.  Transneuronal labelling of neurones projecting to forelimb motoneurones in cats performing different movements , 1986, Brain Research.

[55]  G. Leichnetz Afferent and efferent connections of the dorsolateral precentral gyrus (area 4, hand/arm region) in the macaque monkey, with comparisons to area 8 , 1986, The Journal of comparative neurology.

[56]  R. Passingham Two cortical systems for directing movement. , 1987, Ciba Foundation symposium.

[57]  C. G. Phillips,et al.  A quantitative study of the distribution of neurons projecting to the precentral motor cortex in the monkey (M. fascicularis) , 1987, The Journal of comparative neurology.

[58]  P. Strick,et al.  Corticospinal projections originate from the arcuate premotor area , 1987, Brain Research.

[59]  G Rizzolatti,et al.  Functional organization of inferior area 6. , 1987, Ciba Foundation symposium.

[60]  J. Tanji,et al.  Neuronal activity in cortical motor areas related to ipsilateral, contralateral, and bilateral digit movements of the monkey. , 1988, Journal of neurophysiology.

[61]  G. Rizzolatti,et al.  Thalamic input to inferior area 6 and area 4 in the macaque monkey , 1989, The Journal of comparative neurology.