A mechanism of leading-edge protrusion in the absence of Arp2/3 complex

In the absence of the Arp2/3 complex, fibroblast cells adopt a leading edge with filopodia-like protrusions (FLPs) and maintain an ability to move. In this study, it is proposed that formins are required for the extension of FLPs and myosin II concentrated in arc-like regions in between FLPs is required for coordinated advancement of these regions.

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