CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors
暂无分享,去创建一个
A. Look | A. D’Andrea | R. Kennedy | Clark C. Chen | S. Sidi
[1] Stephen Green,et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies , 2008, Molecular Cancer Therapeutics.
[2] D. Green,et al. Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3 , 2008, Cell.
[3] P. Cohen,et al. The selectivity of protein kinase inhibitors: a further update. , 2007, The Biochemical journal.
[4] Weidong Wang. Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins , 2007, Nature Reviews Genetics.
[5] Akiko Shimamura,et al. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. , 2007, The Journal of clinical investigation.
[6] G. Schwartz,et al. Targeting Checkpoint Kinase 1 in Cancer Therapeutics , 2007, Clinical Cancer Research.
[7] A. D’Andrea,et al. Chk1-Mediated Phosphorylation of FANCE Is Required for the Fanconi Anemia/BRCA Pathway , 2007, Molecular and Cellular Biology.
[8] A. D’Andrea,et al. The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents , 2007, Journal of Molecular Medicine.
[9] Hidetaka Kobayashi,et al. Cell cycle phenotype-based optimization of G2-abrogating peptides yields CBP501 with a unique mechanism of action at the G2 checkpoint , 2007, Molecular Cancer Therapeutics.
[10] Ting-Chao Chou,et al. Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies , 2006, Pharmacological Reviews.
[11] A. D’Andrea,et al. DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[12] A. D’Andrea,et al. Molecular pathogenesis of Fanconi anemia: recent progress. , 2006, Blood.
[13] Z. Estrov,et al. Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. , 2006, Blood.
[14] G. Pond,et al. Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.
[15] A. D’Andrea,et al. The Fanconi Anemia/BRCA pathway: new faces in the crowd. , 2005, Genes & development.
[16] J. Doroshow,et al. The Cyclin-Dependent Kinase Inhibitor UCN-01 Plus Cisplatin in Advanced Solid Tumors: A California Cancer Consortium Phase I Pharmacokinetic and Molecular Correlative Trial , 2005, Clinical Cancer Research.
[17] J. Bartek,et al. Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage , 2005, Molecular and Cellular Biology.
[18] Jeffrey P. MacKeigan,et al. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance , 2005, Nature Cell Biology.
[19] M. Gonen,et al. Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[20] Jiri Bartek,et al. Cell-cycle checkpoints and cancer , 2004, Nature.
[21] A. D’Andrea,et al. ATR couples FANCD2 monoubiquitination to the DNA-damage response. , 2004, Genes & development.
[22] Katia Basso,et al. Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer. , 2004, Cancer research.
[23] Jiri Bartek,et al. Targeting the checkpoint kinases: chemosensitization versus chemoprotection , 2004, Nature Reviews Cancer.
[24] Mei Liu,et al. Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival , 2004, Oncogene.
[25] A. Look,et al. Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. , 2003, Developmental cell.
[26] C. Mathew,et al. Bi‐allelic silencing of the Fanconi anaemia gene FANCF in acute myeloid leukaemia , 2003, British journal of haematology.
[27] C. Mathew,et al. Disruption of the Fanconi anemia–BRCA pathway in cisplatin-sensitive ovarian tumors , 2003, Nature Medicine.
[28] Jiri Bartek,et al. Chk1 and Chk2 kinases in checkpoint control and cancer. , 2003, Cancer cell.
[29] Stephen J. Elledge,et al. MDC1 is a mediator of the mammalian DNA damage checkpoint , 2003, Nature.
[30] A. D’Andrea,et al. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. , 2002, Blood.
[31] Lawrence C. Brody,et al. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage , 2002, Nature Genetics.
[32] A. D’Andrea,et al. Function of the Fanconi anemia pathway in Fanconi anemia complementation group F and D1 cells. , 2001, Experimental hematology.
[33] B. Seed,et al. Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9. , 2001, Blood.
[34] S. Ganesan,et al. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. , 2001, Molecular cell.
[35] W. Brownell,et al. Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems. , 2000, Genes & development.
[36] A. D’Andrea,et al. The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex. , 2000, Blood.
[37] S. Elledge,et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. , 2000, Genes & development.
[38] K. Kinzler,et al. Genetic instabilities in human cancers , 1998, Nature.
[39] D. Näf,et al. Functional Activity of the Fanconi Anemia Protein FAA Requires FAC Binding and Nuclear Localization , 1998, Molecular and Cellular Biology.
[40] E. Guinan,et al. Subtyping Analysis of Fanconi Anemia by Immunoblotting and Retroviral Gene Transfer , 1998, Molecular medicine.
[41] D. Näf,et al. The Fanconi anaemia proteins, FAA and FAC interact to form a nuclear complex , 1997, Nature Genetics.
[42] A. D’Andrea,et al. The effect of the Fanconi anemia polypeptide, FAC, upon p53 induction and G2 checkpoint regulation. , 1996, Blood.
[43] E. Sausville,et al. Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. , 1994, Molecular pharmacology.
[44] A. Eastman,et al. The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. , 2003, Cancer research.
[45] S. Latt,et al. Cytogenetic and flow cytometric studies of cells from patients with Fanconi's anemia. , 1982, Cytogenetics and cell genetics.