Papillary plasma flow in experimental pyelonephritis in rats: effect of antibiotic therapy and indomethacin.

Abstract A defect in Umax is the earliest functional abnormality in pyelonephritis. Administration of inhibitors of renal prostaglandin synthesis (e.g., indomethacin) rapidly and transiently reverse the defect in Umax, suggesting that the defect is mediated by renal prostaglandins. Because medullary prostaglandin synthesis may increase papillary plasma flow which may result in a defect in Umax, papillary plasma flow was determined by measuring the accumulation of 125 I-albumin in the renal papilla of normal rats and rats with early bilateral enterococcal pyelonephritis. In addition, the effect of antibiotic treatment and indomethacin on papillary plasma flow in the infected kidney was determined. Papillary plasma flow was found to be significantly lower in infected rats than in normal rats: 21.9 vs. 31.8 ml/min/100 gm (p

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