Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi’s sarcoma

Disrupting Gal-1 interactions with N-glycans prevents hypoxia-driven angiogenesis to suppress tumorigenesis of Kaposi’s sarcoma

[1]  Y. Miao,et al.  High expression of Galectin‐1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer , 2012, International journal of cancer.

[2]  R. Clark,et al.  Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. , 2012, Blood.

[3]  S. Ralph,et al.  Inhibiting galectin-1 reduces murine lung metastasis with increased CD4+ and CD8+ T cells and reduced cancer cell adherence , 2012, Clinical & Experimental Metastasis.

[4]  G. Rabinovich,et al.  Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer. , 2012, Immunity.

[5]  Brian Keith,et al.  HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression , 2011, Nature Reviews Cancer.

[6]  Napoleone Ferrara,et al.  Developmental and pathological angiogenesis. , 2011, Annual review of cell and developmental biology.

[7]  G. Rabinovich,et al.  Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1. , 2011, Molecular immunology.

[8]  M. Tremblay,et al.  Host-Soluble Galectin-1 Promotes HIV-1 Replication through a Direct Interaction with Glycans of Viral gp120 and Host CD4 , 2011, Journal of Virology.

[9]  Yi Jiang,et al.  Synergistic Induction of Galectin-1 by CCAAT/Enhancer Binding Protein α and Hypoxia-inducible Factor 1α and Its Role in Differentiation of Acute Myeloid Leukemic Cells* , 2011, The Journal of Biological Chemistry.

[10]  S. Tsuboi,et al.  A novel strategy for evasion of NK cell immunity by tumours expressing core2 O‐glycans , 2011, The EMBO journal.

[11]  A. Koong,et al.  Molecular and Cellular Pathobiology Tumor Galectin-1 Mediates Tumor Growth and Metastasis through Regulation of T-cell Apoptosis , 2022 .

[12]  A. Markowska,et al.  Galectin-3 Protein Modulates Cell Surface Expression and Activation of Vascular Endothelial Growth Factor Receptor 2 in Human Endothelial Cells* , 2011, The Journal of Biological Chemistry.

[13]  E. Hirsch,et al.  PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. , 2011, Cancer cell.

[14]  D. Ganem,et al.  Generation of a doxycycline-inducible KSHV producer cell line of endothelial origin: maintenance of tight latency with efficient reactivation upon induction. , 2011, Journal of virological methods.

[15]  Xiu-fen Lei,et al.  Reactive Oxygen Species Hydrogen Peroxide Mediates Kaposi's Sarcoma-Associated Herpesvirus Reactivation from Latency , 2011, PLoS pathogens.

[16]  Michael R. Green,et al.  Viral induction and targeted inhibition of galectin-1 in EBV+ posttransplant lymphoproliferative disorders. , 2011, Blood.

[17]  A. Griffioen,et al.  The Anti-angiogenic Peptide Anginex Greatly Enhances Galectin-1 Binding Affinity for Glycoproteins* , 2011, The Journal of Biological Chemistry.

[18]  Y. Jong,et al.  Lung Cancer-Derived Galectin-1 Mediates Dendritic Cell Anergy through Inhibitor of DNA Binding 3/IL-10 Signaling Pathway , 2011, The Journal of Immunology.

[19]  William M. Gallagher,et al.  An Intact Canonical NF-κB Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia , 2011, The Journal of Immunology.

[20]  C. Casper The increasing burden of HIV-associated malignancies in resource-limited regions. , 2011, Annual review of medicine.

[21]  M. F. Troncoso,et al.  Modulation of endothelial cell migration and angiogenesis: a novel function for the “tandem‐repeat” lectin galectin‐8 , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[22]  Ethel Cesarman,et al.  Kaposi's sarcoma and its associated herpesvirus , 2010, Nature Reviews Cancer.

[23]  Guoqiang Chen,et al.  Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells. , 2010, Carcinogenesis.

[24]  R. Kiss,et al.  Molecular and Cellular Pathobiology Tumor Cells Secrete Galectin-1 to Enhance Endothelial Cell Activity , 2022 .

[25]  A. Molinolo,et al.  Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma , 2010, Proceedings of the National Academy of Sciences.

[26]  P. Desai,et al.  KSHV downregulation of galectin-3 in Kaposi's sarcoma. , 2010, Glycobiology.

[27]  D. Ganem KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. , 2010, The Journal of clinical investigation.

[28]  Fu-Tong Liu,et al.  Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response , 2009, The Journal of experimental medicine.

[29]  G. Rabinovich,et al.  Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10 , 2009, Nature Immunology.

[30]  Howard Y. Chang,et al.  Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. , 2009, Cancer cell.

[31]  E. Cesarman,et al.  Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma , 2009, Proceedings of the National Academy of Sciences.

[32]  Peter Carmeliet,et al.  Regulation of angiogenesis by oxygen and metabolism. , 2009, Developmental cell.

[33]  Carole R. Baskin,et al.  Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection , 2009, PLoS pathogens.

[34]  K. Shokat,et al.  Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma. , 2008, Cancer research.

[35]  M. Wu,et al.  Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells , 2008, Oncogene.

[36]  Katerina Akassoglou,et al.  NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α , 2008, Nature.

[37]  J. Gutkind,et al.  An NF-κB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia , 2008, Oncogene.

[38]  M. Perretti,et al.  Inhibitory control of endothelial galectin‐1 on in vitro and in vivo lymphocyte trafficking , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[39]  K. Shokat,et al.  Dual Inhibition of PI 3 K A and mTOR as an Alternative Treatment for Kaposi ’ s Sarcoma , 2008 .

[40]  S. Monti,et al.  The AP1-dependent secretion of galectin-1 by Reed–Sternberg cells fosters immune privilege in classical Hodgkin lymphoma , 2007, Proceedings of the National Academy of Sciences.

[41]  J. Correale,et al.  Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death , 2007, Nature Immunology.

[42]  S. Rafii,et al.  In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. , 2007, Cancer cell.

[43]  R. Kiss,et al.  Anti-galectin compounds as potential anti-cancer drugs. , 2006, Current medicinal chemistry.

[44]  Ruud P. M. Dings,et al.  Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy , 2006, Proceedings of the National Academy of Sciences.

[45]  P. Chaudhary,et al.  Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-κB activation , 2006, Oncogene.

[46]  James C Paulson,et al.  Sweet spots in functional glycomics , 2006, Nature chemical biology.

[47]  N. Tinari,et al.  Synthetic lactulose amines: novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial cell morphogenesis. , 2006, Glycobiology.

[48]  J. Gutkind,et al.  The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma. , 2006, Cancer research.

[49]  Shuchun Zhao,et al.  Galectin-1: a link between tumor hypoxia and tumor immune privilege. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[50]  Manish Gala,et al.  Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells , 2005, Nature Medicine.

[51]  G. Rabinovich,et al.  Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: involvement of alternative MAPK pathways. , 2005, Glycobiology.

[52]  Gabriel A. Rabinovich,et al.  Galectins as modulators of tumour progression , 2005, Nature Reviews Cancer.

[53]  J. Gutkind,et al.  The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia. , 2004, Blood.

[54]  J. Vieira,et al.  Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression. , 2004, Virology.

[55]  S. Henderson,et al.  Kaposi sarcoma herpesvirus–induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma , 2004, Nature Genetics.

[56]  Mariano J. Alvarez,et al.  Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege. , 2004, Cancer cell.

[57]  D. Davis,et al.  Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Contains Hypoxia Response Elements: Relevance to Lytic Induction by Hypoxia , 2003, Journal of Virology.

[58]  Marion Cornelissen,et al.  Gene expression profile of AIDS-related Kaposi's sarcoma , 2003, BMC Cancer.

[59]  Frederick Y. Wu,et al.  Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-α , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[60]  S. De Flora,et al.  Inhibition of angiogenesis-driven Kaposi's sarcoma tumor growth in nude mice by oral N-acetylcysteine. , 2001, Cancer research.

[61]  Y. Kloog,et al.  Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation , 2001, Oncogene.

[62]  K. Pienta,et al.  Galectin-3 induces endothelial cell morphogenesis and angiogenesis. , 2000, The American journal of pathology.

[63]  G. Rabinovich,et al.  Recombinant Galectin-1 and Its Genetic Delivery Suppress Collagen-Induced Arthritis via T Cell Apoptosis , 1999, The Journal of experimental medicine.

[64]  C. Boshoff,et al.  Kaposi's sarcoma-associated herpesvirus. , 1997, Advances in cancer research.