Functional properties of CD4+CD28− T cells in the aging immune system

[1]  A. Vallejo,et al.  Aging-related Deficiency of CD28 Expression in CD4+ T Cells Is Associated with the Loss of Gene-specific Nuclear Factor Binding Activity* , 1998, The Journal of Biological Chemistry.

[2]  H. Rittner,et al.  Multiple Mechanisms Support Oligoclonal T Cell Expansion in Rheumatoid Synovitis , 1997, Molecular medicine.

[3]  D. Schaid,et al.  Expansion of unusual CD4+ T cells in severe rheumatoid arthritis. , 1997, Arthritis and rheumatism.

[4]  C. Weyand,et al.  Co‐stimulatory pathways controlling activation and peripheral tolerance of human CD4+CD28− T cells , 1997, European journal of immunology.

[5]  G. Pawelec,et al.  The T cell in the ageing individual 1 This article is based on a presentation to the First International Conference on Aging and Immunology, Bethesda, MD, 16–19 June, 1996. 1 , 1997, Mechanisms of Ageing and Development.

[6]  R. Flavell,et al.  The Role of CD40 Ligand in Costimulation and T‐Cell Activation , 1996, Immunological reviews.

[7]  C. Weyand,et al.  The Repertoire of CD4+ CD28− T Cells in Rheumatoid Arthritis , 1996, Molecular medicine.

[8]  G. Kelsoe,et al.  T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1 , 1996, The Journal of experimental medicine.

[9]  Richard A. Miller.  The Aging Immune System: Primer and Prospectus , 1996, Science.

[10]  C. Harley,et al.  Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. , 1996, AIDS.

[11]  C. Thompson,et al.  CD28 is required for germinal center formation. , 1996, Journal of immunology.

[12]  P. Carlson,et al.  Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings. , 1996, Arthritis and rheumatism.

[13]  M. Ritter,et al.  Thymic involution with ageing: obsolescence or good housekeeping? , 1996, Immunology today.

[14]  H. Ostrer,et al.  Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. , 1996, Journal of immunology.

[15]  C. Weyand,et al.  CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. , 1996, The Journal of clinical investigation.

[16]  J. Cerny,et al.  Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice , 1996, The Journal of experimental medicine.

[17]  G. Kelsoe,et al.  Ig VH hypermutation is absent in the germinal centers of aged mice. , 1995, Journal of immunology.

[18]  B Zheng,et al.  Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. , 1995, Journal of immunology.

[19]  L. Notarangelo,et al.  Immunohistologic analysis of ineffective CD40-CD40 ligand interaction in lymphoid tissues from patients with X-linked immunodeficiency with hyper-IgM. Abortive germinal center cell reaction and severe depletion of follicular dendritic cells. , 1995, Journal of immunology.

[20]  J. Goronzy,et al.  Induction of B cell apoptosis by TH0, but not TH2, CD4+ T cells. , 1995, The Journal of clinical investigation.

[21]  G. Kelsoe.  In situ studies of the germinal center reaction. , 1995, Advances in immunology.

[22]  E. Heinen,et al.  Human Germinal Center CD4+ CD57+ T Cells Act Differently On B Cells Than Do Classical T-Helper Cells , 1995, Developmental immunology.

[23]  C. Weyand,et al.  Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis. , 1994, The Journal of clinical investigation.

[24]  H. D. de Weerd,et al.  Mel14+ CD4+ T cells from aged mice display functional and phenotypic characteristics of memory cells. , 1994, International immunology.

[25]  A. Aruffo,et al.  gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory , 1994, The Journal of experimental medicine.

[26]  H. Ochs,et al.  Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction. , 1994, Journal of immunology.

[27]  C. Engwerda,et al.  Aged T cells are hyporesponsive to costimulation mediated by CD28. , 1994, Journal of immunology.

[28]  J. Cerny,et al.  Distinct pathways of B cell differentiation. I. Residual T cells in athymic mice support the development of splenic germinal centers and B cell memory without an induction of antibody. , 1994, Journal of immunology.

[29]  I. Weissman.  Developmental switches in the immune system , 1994, Cell.

[30]  B. Fowlkes,et al.  Selective events in T cell development. , 1994, Annual review of immunology.

[31]  R. Callard,et al.  CD40 ligand and its role in X-linked hyper-IgM syndrome. , 1993, Immunology today.

[32]  W. Kindermann,et al.  Age‐related increase of CD45RO+ lymphocytes in physically active adults , 1993, European journal of immunology.

[33]  K. Hirokawa,et al.  Influence of age on the signal transduction of T cells in mice. , 1993, International immunology.

[34]  R. Miller,et al.  Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets. Effect of age. , 1993, Journal of immunology.

[35]  D. Noonan,et al.  The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression. , 1993, Journal of immunology.

[36]  Y. H. Kim,et al.  Age-related effects in T cell activation and proliferation , 1993, Experimental Gerontology.

[37]  B. Torbett,et al.  Patterns of cytokine gene expression by CD4+ T cells from young and old mice. , 1993, Journal of immunology.

[38]  P. Linsley,et al.  The role of the CD28 receptor during T cell responses to antigen. , 1993, Annual review of immunology.

[39]  B. Rocha,et al.  Lymphocyte lifespans: homeostasis, selection and competition. , 1993, Immunology today.

[40]  K. Hirokawa.  Understanding the mechanism of the age-related decline in immune function. , 2009, Nutrition reviews.

[41]  P. Linsley,et al.  Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. , 1992, Science.

[42]  C. Weyand,et al.  Selective induction of rheumatoid factors by superantigens and human helper T cells. , 1992, The Journal of clinical investigation.

[43]  J. Cerny,et al.  The repertoire diversity and magnitude of antibody responses to bacterial antigens in aged mice: I. Age-associated changes in antibody responses differ according to the mouse strain. , 1991, Cellular immunology.

[44]  A. Dräger,et al.  Age‐related changes in lymphokine production related to a decreased number of CD45RBhi CD4+ T cells , 1991, European journal of immunology.

[45]  K. Marcu,et al.  Altered VH gene segment utilization in the response to phosphorylcholine by aged mice. , 1989, Journal of immunology.

[46]  Richard A. Miller,et al.  Pgp‐1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A , 1989, European journal of immunology.

[47]  G. Thorbecke,et al.  Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) mice. , 1974, Cellular immunology.