Genetics and psychiatry: an unheralded window on the environment.

Two recent reviews in the American Journal of Psychiatry and the British Journal of Psychiatry reported on progress in understanding the genetics of psychiatric disorder. Both reviews focused on this progress as a prelude to psychiatric diagnostics and therapeutics based on molecular biology. Neither review recognized that the latest data in behavioral genetics support environmental causes for abnormal development and psychopathology as much as they support genetic causes. Moreover, these genetic data point clearly to a type of environmental cause with central importance: the environment that is specific or unique to each sibling in a family.

[1]  E. Hetherington.  Coping with Marital Transitions: A Family Systems Perspective , 1992 .

[2]  R. Plomin.  The role of inheritance in behavior. , 1990, Science.

[3]  R. Plomin,et al.  Nonshared experiences within the family: Correlates of behavioral problems in middle childhood , 1990, Development and Psychopathology.

[4]  K. Kidd,et al.  Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish , 1989, Nature.

[5]  R. Murray,et al.  The Impact of Molecular Genetics on Our Understanding of the Psychoses , 1989, British Journal of Psychiatry.

[6]  H. Pincus,et al.  Genetics and psychiatry: past discoveries, current dilemmas, and future directions. , 1989, The American journal of psychiatry.

[7]  C. MacKinnon.  Influences on Sibling Relations in Families with Married and Divorced Parents , 1988 .

[8]  John P. Rice,et al.  The familial transmission of bipolar illness. , 1987, Archives of general psychiatry.

[9]  D. Reiss,et al.  Couples at risk for transmission of alcoholism: protective influences. , 1987, Family process.

[10]  A. Jensen,et al.  Why are children in the same family so different from one another? , 1987, Behavioral and Brain Sciences.

[11]  S. Kety,et al.  Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders. , 1986, Archives of general psychiatry.

[12]  R. Plomin,et al.  Consistency of Mothers' Behavior Toward Infant Siblings. , 1985 .

[13]  R. Plomin,et al.  Environmental differences within the family and adjustment differences within pairs of adolescent siblings. , 1985, Child development.

[14]  R. Murray,et al.  Twin concordance for operationally defined schizophrenia. Confirmation of familiality and heritability. , 1984, Archives of general psychiatry.

[15]  G. Margolin,et al.  Patterns of alliances in nondistressed and multiproblem families. , 1984, Family process.

[16]  K. Kendler,et al.  Schizophrenia in the National Academy of Sciences-National Research Council Twin Registry: a 16-year update. , 1983, The American journal of psychiatry.

[17]  H. Goldsmith.  Genetic influences on personality from infancy to adulthood. , 1983, Child development.

[18]  S. Scarr,et al.  How people make their own environments: a theory of genotype greater than environment effects. , 1983, Child development.

[19]  S. Scarr,et al.  The Minnesota Adoption Studies: genetic differences and malleability. , 1983, Child development.

[20]  Richard J. Haier,et al.  Schizophrenia: The epigenetic puzzle Cambridge University Press, Cambridge (1982). 258 pp. by Irving I. Gottesman and James Shields , 1982, Psychiatry Research.

[21]  F. Schachter,et al.  Sibling Deidentification Judged by Mothers: Cross-Validation and Developmental Studies. , 1978 .

[22]  A. Bertelsen,et al.  A Danish Twin Study of Manic-Depressive Disorders , 1977, British Journal of Psychiatry.

[23]  R. Q. Bell.  A reinterpretation of the direction of effects in studies of socialization. , 1968, Psychological review.

[24]  L. Bank,et al.  An early starter model for predicting delinquency. , 1991 .

[25]  D. Daniels,et al.  Nonshared environmental influences and personality differences in adult twins. , 1990, Journal of personality and social psychology.

[26]  R. Plomin,et al.  Nature and nurture during infancy and early childhood: Conclusions , 1988 .

[27]  R. Plomin,et al.  Differential Experience of Siblings in the Same Family. , 1985 .

[28]  R. Plomin,et al.  The importance of nonshared (E-sub-1) environmental influences in behavioral development. , 1981 .