Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.
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R. Magolda | M. Covington | C. Decicco | R. Wexler | W. Yao | R. Newton | Z. Wasserman | M. Qian | D. Christ | M. Tortorella | M. Pratta | M. Ribadeneira | R. Liu | M. Chao | G. Reddy | E. Shi | E. Arner