论文信息 - The effect of 1-trans-delta 9-tetrahydrocannabinol on the hypothalamo-hypophyseal-adrenal axis of rats.

The effect of 1-trans-delta 9-tetrahydrocannabinol on the hypothalamo-hypophyseal-adrenal axis of rats.

Abstract 1-trans- Δ 9 -Tetrahydrocannabinol ( Δ 9 -THC) was found to be a potent stimulator of ACTH secretion, as evidenced by depletion of adrena ascorbic acid in rats. Low doses of Δ 9 -THC that were inactive in unanesthetized rats stimulated ACTH secretion in pentobarbital anesthetized rats. This observation differentiates Δ 9 -THC from other drugs reported to stimulate ACTH secretion. A nonstimulating dose of Δ 9 -THC did not block the secretion of ACTH induced by epinephrine. The concentration of adrenal ascorbic acid one hour after a fifth daily injection did not differ significantly from that observed after a single injection.

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