Jcb: Report Introduction

Cells sense the overall chromosome congression state in metaphase to promote anaphase entry using RanGTP, which induces the reduction of two spindle assembly checkpoint proteins, BuGZ and Bub3, via the E3 ligase Ubr5.

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[47]  Hongbin Sun,et al.  Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition , 2010, Proceedings of the National Academy of Sciences.

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[51]  N. Kanu,et al.  UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function , 2014, Proceedings of the National Academy of Sciences.

[52]  Yixian Zheng,et al.  Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. , 2004, Genes & development.

[53]  Karsten Weis,et al.  Visualization of a Ran-GTP Gradient in Interphase and Mitotic Xenopus Egg Extracts , 2002, Science.

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[59]  P. Sorger,et al.  A dual role for Bub1 in the spindle checkpoint and chromosome congression , 2005, The EMBO journal.

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[61]  T. Hori,et al.  Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase , 2010, The Journal of cell biology.

[62]  Yixian Zheng,et al.  Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran. , 1999, Science.

[63]  Y. Xiong,et al.  Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. , 2011, Molecular cell.