CHAPTER 8 – Osteocytes

[1]  Y. Mikuni‐Takagaki,et al.  Matrix mineralization and the differentiation of osteocyte‐like cells in culture , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[2]  T. Hentunen,et al.  Osteocytes inhibit osteoclastic bone resorption through transforming growth factor‐β: Enhancement by estrogen * , 2002, Journal of cellular biochemistry.

[3]  T. Gross,et al.  Upregulation of Osteopontin by Osteocytes Deprived of Mechanical Loading or Oxygen , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[4]  Mark L. Johnson,et al.  The gene for high bone mass , 2002 .

[5]  H. Jüppner,et al.  Receptors specific for the carboxyl-terminal region of parathyroid hormone on bone-derived cells: determinants of ligand binding and bioactivity. , 2005, Endocrinology.

[6]  K. Nose,et al.  Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells. , 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[7]  P. Mangeat,et al.  ERM proteins in cell adhesion and membrane dynamics. , 1999, Trends in cell biology.

[8]  A. Mustafa,et al.  The glutamate transporter GLAST-1 (EAAT-1) is expressed in the plasma membrane of osteocytes and is responsive to extracellular glutamate concentration. , 2001, Biochemical Society transactions.

[9]  D. Salter,et al.  CD44 expression in human bone: A novel marker of osteocytic differentiation , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[10]  M. Karsdal,et al.  Matrix metalloproteinases (MMPs) safeguard osteoblasts from apoptosis during transdifferentiation into osteocytes: MT1-MMP maintains osteocyte viability. , 2004, DNA and cell biology.

[11]  T. Clemens,et al.  Selected Contribution: Osteocytes upregulate HIF-1alpha in response to acute disuse and oxygen deprivation. , 2001, Journal of applied physiology.

[12]  Jing Zhou,et al.  Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells , 2003, Nature Genetics.

[13]  Melissa L. Knothe Tate,et al.  Whither flows the fluid in bone?" An osteocyte's perspective. , 2003 .

[14]  A. Boskey,et al.  Matrix proteins and mineralization: an overview. , 1996, Connective tissue research.

[15]  A. Weidema,et al.  Voltage, calcium, and stretch activated ionic channels and intracellular calcium in bone cells , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[16]  M Dioszegi,et al.  Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). , 2001, Human molecular genetics.

[17]  S. Ashrafi,et al.  The Canalicular Structure of Compact Bone in the Rat at Different Ages , 2002, Microscopy and Microanalysis.

[18]  D. Carnes,et al.  Surface plasmon resonance (SPR) confirms that MEPE binds to PHEX via the MEPE-ASARM motif: a model for impaired mineralization in X-linked rickets (HYP). , 2005, Bone.

[19]  N. Fedarko,et al.  Six Genes Expressed in Bones and Teeth Encode the Current Members of the SIBLING Family of Proteins , 2003, Connective tissue research.

[20]  H. Weinans,et al.  Long‐term serotonin administration leads to higher bone mineral density, affects bone architecture, and leads to higher femoral bone stiffness in rats , 2006, Journal of cellular biochemistry.

[21]  H. Donahue,et al.  Connexin expression by alveolar epithelial cells is regulated by extracellular matrix. , 2001, American journal of physiology. Lung cellular and molecular physiology.

[22]  J. Wergedal,et al.  Bone formation by osteocytes. , 1971, The American journal of physiology.

[23]  E H Burger,et al.  Pulsating Fluid Flow Stimulates Prostaglandin Release and Inducible Prostaglandin G/H Synthase mRNA Expression in Primary Mouse Bone Cells , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[24]  Sheldon Weinbaum,et al.  In situ measurement of solute transport in the bone lacunar‐canalicular system , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[25]  K. Fjeld,et al.  NK1, NK2, NK3 and CGRP1 receptors identified in rat oral soft tissues, and in bone and dental hard tissue cells , 2003, Cell and Tissue Research.

[26]  A. Robling,et al.  Mechanotransduction in bone: genetic effects on mechanosensitivity in mice. , 2002, Bone.

[27]  L. Bonewald,et al.  Mechanical Loading Stimulates Dentin Matrix Protein 1 (DMP1) Expression in Osteocytes In Vivo , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[28]  T. Nagata,et al.  Effect of prostaglandin E2 on mineralization of bone nodules formed by fetal rat calvarial cells , 1994, Calcified Tissue International.

[29]  Stephen B Doty,et al.  Delineating bone's interstitial fluid pathway in vivo. , 2004, Bone.

[30]  L. Lanyon,et al.  Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone. , 2003, American journal of physiology. Cell physiology.

[31]  M. Karsdal,et al.  Matrix Metalloproteinase-dependent Activation of Latent Transforming Growth Factor-β Controls the Conversion of Osteoblasts into Osteocytes by Blocking Osteoblast Apoptosis* , 2002, The Journal of Biological Chemistry.

[32]  M. Glimcher,et al.  Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1) , 1996, Science.

[33]  J. Robb,et al.  Electrophysiological Responses of Human Bone Cells to Mechanical Stimulation: Evidence for Specific Integrin Function in Mechanotransduction , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[34]  D. Paul,et al.  Connexins, connexons, and intercellular communication. , 1996, Annual review of biochemistry.

[35]  R. Sierra,et al.  Osteonecrosis of the femoral head. , 1999, The Journal of the American Academy of Orthopaedic Surgeons.

[36]  Xi Jiang,et al.  Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. , 2004, Bone.

[37]  S. Manolagas,et al.  Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs. , 2006, Bone.

[38]  R. Recker,et al.  Bone biomechanical properties in LRP5 mutant mice. , 2004, Bone.

[39]  T. Takano-Yamamoto,et al.  A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy. , 2001, Bone.

[40]  T. Komori,et al.  Dentin Matrix Protein 1 Is Predominantly Expressed in Chicken and Rat Osteocytes But Not in Osteoblasts , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[41]  L. Lanyon,et al.  Regulation of bone formation by applied dynamic loads. , 1984, The Journal of bone and joint surgery. American volume.

[42]  C. Jacobs,et al.  Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. , 2003, Bone.

[43]  L. Bonewald,et al.  Dmp1-deficient Mice Display Severe Defects in Cartilage Formation Responsible for a Chondrodysplasia-like Phenotype* , 2005, Journal of Biological Chemistry.

[44]  Toshitaka Nakamura,et al.  Role of Inducible Nitric Oxide Synthase in Skeletal Adaptation to Acute Increases in Mechanical Loading , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[45]  HE F. Comparative investigations of the function of osteocytes in bone resorption , 2005, Calcified Tissue Research.

[46]  H. Birkedal‐Hansen,et al.  The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone , 2005, Journal of Cell Science.

[47]  C. Jacobs,et al.  Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism. , 2003, Bone.

[48]  T. Hentunen,et al.  Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblasts. , 2004, Experimental cell research.

[49]  B. Lanske,et al.  Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. , 1996, Bone.

[50]  E H Burger,et al.  Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes--a cytoskeleton-dependent process. , 1996, Biochemical and biophysical research communications.

[51]  M. Schwartz,et al.  Integrins in Mechanotransduction* , 2004, Journal of Biological Chemistry.

[52]  D. Seldin,et al.  T1alpha, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth. , 2003, Developmental biology.

[53]  R. Shoemaker,et al.  Cell-to-Cell Communication of Osteoblasts , 1979, Journal of dental research.

[54]  Glimcher Mj,et al.  Accumulative cell stress: the multifactorial etiology of idiopathic osteonecrosis. , 1985 .

[55]  M. Owen CELL POPULATION KINETICS OF AN OSTEOGENIC TISSUE · I , 1963, The Journal of cell biology.

[56]  M. Forwood,et al.  Inducible cyclo‐oxygenase (COX‐2) mediates the induction of bone formation by mechanical loading in vivo , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[57]  C. Jacobs,et al.  Functional Gap Junctions Between Osteocytic and Osteoblastic Cells , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[58]  E. Ritz,et al.  The influence of immobilization on osteocyte morphology , 1976, Virchows Archiv.

[59]  L. Bonewald,et al.  Establishment of an Osteocyte‐like Cell Line, MLO‐Y4 , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[60]  P. Nijweide,et al.  Biochemical and histological studies on various bone cell preparations , 2006, Calcified Tissue International.

[61]  F. Glorieux,et al.  Relation between hypomineralized periosteocytic lesions and bone mineralization in vitamin D-resistant rickets , 1983, Calcified Tissue International.

[62]  L. Bonewald,et al.  PGE(2) is essential for gap junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain. , 2001, Endocrinology.

[63]  Sheldon Weinbaum,et al.  On bone adaptation due to venous stasis. , 2003, Journal of biomechanics.

[64]  D. Rao,et al.  Relationships between osteocyte density and bone formation rate in human cancellous bone. , 2002, Bone.

[65]  L. Lanyon,et al.  The Effect of In Vivo Mechanical Loading on Estrogen Receptor α Expression in Rat Ulnar Osteocytes , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[66]  P. Nijweide,et al.  Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis. , 2004, Life sciences.

[67]  Jiliang Li,et al.  The P2X7 Nucleotide Receptor Mediates Skeletal Mechanotransduction* , 2005, Journal of Biological Chemistry.

[68]  Parfitt Am,et al.  The cellular basis of bone turnover and bone loss: a rebuttal of the osteocytic resorption--bone flow theory. , 1977 .

[69]  S. Manolagas Choreography from the tomb: An emerging role of dying osteocytes in the purposeful, and perhaps not so purposeful, targeting of bone remodeling , 2006 .

[70]  A. van der Plas,et al.  Expression of Serotonin Receptors in Bone* , 2001, The Journal of Biological Chemistry.

[71]  F. Giancotti,et al.  Complexity and specificity of integrin signalling , 2000, Nature Cell Biology.

[72]  John A Latham,et al.  Osteocyte control of bone formation via sclerostin, a novel BMP antagonist , 2003, The EMBO journal.

[73]  C. Turner,et al.  Effects of Loading Frequency on Mechanically Induced Bone Formation , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[74]  D. Rao,et al.  Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone. , 2002, Bone.

[75]  J. Reeve,et al.  The FASEB Journal express article 10.1096/fj.05-4221fje. Published online August 25, 2005. ©2005 FASEB , 2022 .

[76]  D. Burr,et al.  A Model for mechanotransduction in bone cells: The load‐bearing mechanosomes , 2003, Journal of cellular biochemistry.

[77]  M. HELLER-STEINBERG,et al.  Ground substance, bone salts, and cellular activity in bone formation and destruction. , 1951, The American journal of anatomy.

[78]  B. Hall,et al.  Buried alive: How osteoblasts become osteocytes , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

[79]  Stephen C. Cowin,et al.  Modeling Tracer Transport in an Osteon under Cyclic Loading , 2004, Annals of Biomedical Engineering.

[80]  B. Kream,et al.  Regulation of bone formation (second of two parts). , 1983, The New England journal of medicine.

[81]  D. Rao,et al.  Differences in osteocyte and lacunar density between Black and White American women. , 2006, Bone.

[82]  L. Lanyon,et al.  The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta. , 2004, The Journal of endocrinology.

[83]  E H Burger,et al.  Signal transduction pathways involved in fluid flow-induced PGE2 production by cultured osteocytes. , 1999, American journal of physiology. Endocrinology and metabolism.

[84]  Y. Mikuni‐Takagaki,et al.  Distinct responses of different populations of bone cells to mechanical stress. , 1996, Endocrinology.

[85]  L. Plotkin,et al.  Bisphosphonate-Induced, Hemichannel-Mediated, Anti-Apoptosis Through the Src/ERK Pathway: A Gap Junction-Independent Action of Connexin43 , 2001, Cell communication & adhesion.

[86]  F. R. Bringhurst,et al.  Receptors for the Carboxyl-Terminal Region of PTH(1-84) Are Highly Expressed in Osteocytic Cells* *This work was supported by the NIH Grant DK-11794. , 2001, Endocrinology.

[87]  L. Bonewald,et al.  Mechanism by which MLO-A5 Late Osteoblasts/Early Osteocytes Mineralize in Culture: Similarities with Mineralization of Lamellar Bone , 2006, Calcified Tissue International.

[88]  S. Dedhar,et al.  Integrin expression in human bone , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[89]  N. Lane An update on glucocorticoid-induced osteoporosis. , 2001, Rheumatic diseases clinics of North America.

[90]  M. V. Bennett,et al.  Gap junctions, electrotonic coupling, and intercellular communication. , 1978, Neurosciences Research Program bulletin.

[91]  L. Bonewald,et al.  MLO‐Y4 Osteocyte‐Like Cells Support Osteoclast Formation and Activation , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[92]  T. Gross,et al.  Osteocyte hypoxia: a novel mechanotransduction pathway. , 1999, American journal of physiology. Cell physiology.

[93]  David L. Paul,et al.  Beyond the gap: functions of unpaired connexon channels , 2003, Nature Reviews Molecular Cell Biology.

[94]  S. Manolagas,et al.  Transduction of Cell Survival Signals by Connexin-43 Hemichannels* , 2002, The Journal of Biological Chemistry.

[95]  L. Lanyon,et al.  Early loading‐related changes in the activity of glucose 6‐phosphate dehydrogenase and alkaline phosphatase in osteocytes and periosteal osteoblasts in rat fibulae in vivo , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[96]  J. Stock,et al.  Targeted Disruption of the Osteoblast/Osteocyte Factor 45 Gene (OF45) Results in Increased Bone Formation and Bone Mass* , 2003, The Journal of Biological Chemistry.

[97]  K. Metsikkö,et al.  Isolated primary osteocytes express functional gap junctions in vitro , 2006, Cell and Tissue Research.

[98]  L. Bonewald,et al.  Effects of Mechanical Strain on the Function of Gap Junctions in Osteocytes Are Mediated through the Prostaglandin EP2 Receptor* , 2003, Journal of Biological Chemistry.

[99]  Stephen E. Harris,et al.  E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation , 2006, Molecular and Cellular Biology.

[100]  R. Evans,et al.  Bone death in hip fracture in the elderly , 1990, Calcified Tissue International.

[101]  P. Roberson,et al.  Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. , 1999, The Journal of clinical investigation.

[102]  L. Bonewald,et al.  Dentin Matrix Protein 1 Gene Cis-regulation , 2005, Journal of Biological Chemistry.

[103]  Kenneth D Brandt,et al.  Etiopathogenesis of osteoarthritis. , 2008, Rheumatic diseases clinics of North America.

[104]  H. Hagino,et al.  Effect of a selective agonist for prostaglandin E receptor subtype EP4 (ONO-4819) on the cortical bone response to mechanical loading. , 2005, Bone.

[105]  O. Verborgt,et al.  Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[106]  Daniel P Nicolella,et al.  Measurement of microstructural strain in cortical bone. , 2005, European journal of morphology.

[107]  T. Meitinger,et al.  Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. , 1997, Human molecular genetics.

[108]  E. Gormally,et al.  Mouse mutants carrying deletions that remove the genes mutated in Coffin-Lowry syndrome and lactic acidosis. , 1998, Human molecular genetics.

[109]  Y. Mikuni‐Takagaki,et al.  Distinct Anabolic Response of Osteoblast to Low‐Intensity Pulsed Ultrasound , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[110]  E H Burger,et al.  The production of nitric oxide and prostaglandin E(2) by primary bone cells is shear stress dependent. , 2001, Journal of biomechanics.

[111]  L. Lanyon,et al.  Early strain‐related changes in enzyme activity in osteocytes following bone loading in vivo , 1989, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[112]  L. Lanyon,et al.  Mechanical Loading Influences Bone Mass Through Estrogen Receptor &agr; , 2004, Exercise and sport sciences reviews.

[113]  Teruko Takano-Yamamoto,et al.  Terminal Differentiation of Osteoblasts to Osteocytes Is Accompanied by Dramatic Changes in the Distribution of Actin‐Binding Proteins , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[114]  K. Saag Glucocorticoid-induced osteoporosis. , 2003, Endocrinology and metabolism clinics of North America.

[115]  R. Cruess,et al.  The etiology of steroid-induced avascular necrosis of bone. A laboratory and clinical study. , 1975, Clinical orthopaedics and related research.

[116]  J. Whitfield Primary cilium—is it an osteocyte's strain‐sensing flowmeter? , 2003, Journal of cellular biochemistry.

[117]  B. Katzenellenbogen,et al.  Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity , 2001, Cell.

[118]  J. Aubin,et al.  Developmental Expression and Tissue Distribution of Phex Protein: Effect of the Hyp Mutation and Relationship to Bone Markers , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[119]  S. Vilaró,et al.  Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes. , 1999, Journal of cell science.

[120]  M. Balooch,et al.  Glucocorticoid‐Treated Mice Have Localized Changes in Trabecular Bone Material Properties and Osteocyte Lacunar Size That Are Not Observed in Placebo‐Treated or Estrogen‐Deficient Mice , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[121]  S. Cowin,et al.  Candidates for the mechanosensory system in bone. , 1991, Journal of biomechanical engineering.

[122]  M. Parker,et al.  The Ratio of Osteocytic Incorporation to Bone Matrix Formation in Femoral Neck Cancellous Bone: An Enhanced Osteoblast Work Rate in the Vicinity of Hip Osteoarthritis , 2003, Calcified Tissue International.

[123]  L. Lanyon,et al.  Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. , 1996, Bone.

[124]  D. Burr,et al.  Effects of biomechanical stress on bones in animals. , 2002, Bone.

[125]  Alexander G Robling,et al.  Shorter, more frequent mechanical loading sessions enhance bone mass. , 2002, Medicine and science in sports and exercise.

[126]  B. Frenkel,et al.  Role of apoptosis in glucocorticoid-induced osteoporosis and osteonecrosis. , 2003, Critical reviews in eukaryotic gene expression.

[127]  D Vashishth,et al.  Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age. , 2000, Bone.

[128]  J. Polak,et al.  Apoptosis--a significant cause of bone cell death in osteonecrosis of the femoral head. , 2004, The Journal of bone and joint surgery. British volume.

[129]  J. Klein-Nulend,et al.  MECHANOTRANSDUCTION IN BONE : ROLE OF THE LACUNOCANALICULAR NETWORK , 1999 .

[130]  L. Lanyon,et al.  Early strain‐related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[131]  S. Doty Morphological evidence of gap junctions between bone cells , 2006, Calcified Tissue International.

[132]  L. Bonewald,et al.  Expression of Functional Gap Junctions and Regulation by Fluid Flow in Osteocyte‐Like MLO‐Y4 Cells , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[133]  W. Carter,et al.  Cellular Interaction of Integrin α3β1 with Laminin 5 Promotes Gap Junctional Communication , 1998, The Journal of cell biology.

[134]  K. White,et al.  MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. , 2000, Genomics.

[135]  H. Donahue,et al.  Gap junctions and biophysical regulation of bone cell differentiation. , 2000, Bone.

[136]  S. Cowin,et al.  A case for bone canaliculi as the anatomical site of strain generated potentials. , 1995, Journal of biomechanics.

[137]  C. Gabel,et al.  Absence of the P2X7 Receptor Alters Leukocyte Function and Attenuates an Inflammatory Response , 2002, The Journal of Immunology.

[138]  D. Rao,et al.  Reduced Iliac Cancellous Osteocyte Density in Patients With Osteoporotic Vertebral Fracture , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[139]  A. van der Plas,et al.  Characteristics and properties of osteocytes in culture , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[140]  D. Woodbury,et al.  The effects of prostaglandin E2 in growing rats: Increased metaphyseal hard tissue and cortico-endosteal bone formation , 2007, Calcified Tissue International.

[141]  N. Rushton,et al.  Patterns of osteocytic endothelial nitric oxide synthase expression in the femoral neck cortex: differences between cases of intracapsular hip fracture and controls. , 2002, Bone.

[142]  R. Rivera-Gonzalez,et al.  Identification of Osteoblast/Osteocyte Factor 45 (OF45), a Bone-specific cDNA Encoding an RGD-containing Protein That Is Highly Expressed in Osteoblasts and Osteocytes* , 2000, The Journal of Biological Chemistry.

[143]  G. Marotti,et al.  Osteocyte dendrogenesis in static and dynamic bone formation: an ultrastructural study. , 2004, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology.

[144]  M. Kasper,et al.  Immunohistochemical investigations on the differentiation marker protein E11 in rat calvaria, calvaria cell culture and the osteoblastic cell line ROS 17/2.8 , 1999, Histochemistry and Cell Biology.

[145]  F. Hughes,et al.  Immunocytochemical investigation of the rat cementoblast phenotype. , 1993, Journal of periodontal research.

[146]  P. Nijweide,et al.  Function of osteocytes in bone , 1994, Journal of cellular biochemistry.

[147]  M. Takagi,et al.  In situ Localization and in vitro Expression of Osteoblast/Osteocyte Factor 45 mRNA during Bone Cell Differentiation , 2002, The Histochemical Journal.

[148]  P. Nasser,et al.  The Role of Interstitial Fluid Flow in the Remodeling Response to Fatigue Loading , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[149]  Melissa L Knothe Tate,et al.  "Whither flows the fluid in bone?" An osteocyte's perspective. , 2003, Journal of biomechanics.

[150]  A. Parfitt,et al.  Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. , 1998, The Journal of clinical investigation.

[151]  P. Nijweide,et al.  Osteocyte‐Specific Monoclonal Antibody MAb OB7.3 Is Directed Against Phex Protein , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[152]  S. Pollack,et al.  Comparative analysis of diffusive and stress induced nutrient transport efficiency in the lacunar-canalicular system of osteons. , 2003, Biorheology.

[153]  G. Russell,et al.  Oestradiol inhibits the release of tumour necrosis factor but not interleukin 6 from adult human osteoblasts in vitro , 1992, Osteoporosis International.

[154]  T. Steinberg,et al.  Connexin43 Deficiency Causes Delayed Ossification, Craniofacial Abnormalities, and Osteoblast Dysfunction , 2000, The Journal of cell biology.

[155]  S. Cowin,et al.  A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. , 1994, Journal of biomechanics.

[156]  L. Lanyon Osteocytes, strain detection, bone modeling and remodeling , 2005, Calcified Tissue International.

[157]  Y. Yamaguchi,et al.  Isolated chick osteocytes stimulate formation and bone-resorbing activity of osteoclast-like cells , 2005, Journal of Bone and Mineral Metabolism.

[158]  R. Weinstein,et al.  Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip. , 2000, The Journal of clinical endocrinology and metabolism.

[159]  Daniel P Nicolella,et al.  Osteocyte lacunae tissue strain in cortical bone. , 2006, Journal of biomechanics.

[160]  Sheldon Weinbaum,et al.  Mechanotransduction and strain amplification in osteocyte cell processes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[161]  Xiao-Fan Wang,et al.  The Loss of Smad3 Results in a Lower Rate of Bone Formation and Osteopenia Through Dysregulation of Osteoblast Differentiation and Apoptosis , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[162]  D B Burr,et al.  In vivo measurement of human tibial strains during vigorous activity. , 1996, Bone.

[163]  A. George,et al.  Dentin Matrix Protein 1 Immobilized on Type I Collagen Fibrils Facilitates Apatite Deposition in Vitro* , 2004, Journal of Biological Chemistry.

[164]  Kosaku Kurata,et al.  Bone Marrow Cell Differentiation Induced by Mechanically Damaged Osteocytes in 3D Gel‐Embedded Culture , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[165]  Y. Tsutsumi,et al.  Association of CD44 with OTS-8 in tumor vascular endothelial cells. , 2000, Biochimica et biophysica acta.

[166]  L. Bonewald,et al.  Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO‐Y4 osteocyte‐like cells and ROS 17/2.8 osteoblast‐like cells , 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[167]  Mark L. Johnson,et al.  A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. , 2002, American journal of human genetics.

[168]  Establishment and hormonal regulation of a conditionally transformed preosteocytic cell line from adult human bone. , 1996, Endocrinology.

[169]  A. Poustka,et al.  A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets , 1995, Nature Genetics.

[170]  A. van der Plas,et al.  Sensitivity of osteocytes to biomechanical stress in vitro , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[171]  G. Marotti,et al.  Morphological study of intercellular junctions during osteocyte differentiation. , 1990, Bone.

[172]  H. Ris,et al.  Osteocyte Shape Is Dependent on Actin Filaments and Osteocyte Processes Are Unique Actin‐Rich Projections , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[173]  S. Manolagas,et al.  Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. , 2000, Endocrine reviews.

[174]  Peng Liu,et al.  Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling* , 2005, Journal of Biological Chemistry.

[175]  L. Bonewald,et al.  Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. , 2005, Molecular biology of the cell.

[176]  Christopher R Jacobs,et al.  Fluid flow induced PGE2 release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not. , 2003, Biorheology.

[177]  Di Chen,et al.  MEPE has the properties of an osteoblastic phosphatonin and minhibin. , 2004, Bone.

[178]  R. Jilka,et al.  Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. , 2005, Endocrinology.

[179]  D. Rowe,et al.  Use of Type I Collagen Green Fluorescent Protein Transgenes to Identify Subpopulations of Cells at Different Stages of the Osteoblast Lineage , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[180]  S. Krane,et al.  Osteocyte and osteoblast apoptosis and excessive bone deposition accompany failure of collagenase cleavage of collagen. , 2000, The Journal of clinical investigation.

[181]  D. H. Carter,et al.  Patterns of integrin expression in a human mandibular explant model of osteoblast differentiation. , 2001, Archives of oral biology.

[182]  E. Bonucci,et al.  Osteocyte ultrastructure in renal osteodystrophy , 1977, Virchows Archiv A.

[183]  R. Duncan,et al.  Fluid Shear‐Induced ATP Secretion Mediates Prostaglandin Release in MC3T3‐E1 Osteoblasts , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[184]  E. Canalis,et al.  Effects of prostaglandin E2 on bone formation in cultured fetal rat calvariae: role of insulin-like growth factor-I. , 1993, Endocrinology.

[185]  E. Puscheck,et al.  Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[186]  L. Bonewald,et al.  Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism , 2006, Nature Genetics.

[187]  Stuart J Warden,et al.  Mechanotransduction in Bone Does Not Require a Functional Cyclooxygenase‐2 (COX‐2) Gene , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[188]  C. Jacobs,et al.  Gap junctions and fluid flow response in MC3T3-E1 cells. , 2001, American journal of physiology. Cell physiology.

[189]  P. Hauschka,et al.  Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. , 1996, The Biochemical journal.

[190]  W. Fraser,et al.  Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets. , 2004, The Journal of endocrinology.

[191]  L. Bonewald,et al.  CD40 ligand blocks apoptosis induced by tumor necrosis factor alpha, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4. , 2003, Endocrinology.

[192]  Theo H Smit,et al.  A Case for Strain‐Induced Fluid Flow as a Regulator of BMU‐Coupling and Osteonal Alignment , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[193]  Clinton T. Rubin,et al.  Regulation of bone mass by mechanical strain magnitude , 1985, Calcified Tissue International.

[194]  R. Recker,et al.  Mechanical loading stimulates rapid changes in periosteal gene expression , 1994, Calcified Tissue International.

[195]  W. Ambrosius,et al.  Mechanical Loading of Diaphyseal Bone In Vivo: The Strain Threshold for an Osteogenic Response Varies with Location , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[196]  D. Burr,et al.  Partitioning a Daily Mechanical Stimulus into Discrete Loading Bouts Improves the Osteogenic Response to Loading , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[197]  A. van der Plas,et al.  Isolation and purification of osteocytes , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[198]  M. Karperien,et al.  Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist , 2004, The Journal of experimental medicine.

[199]  R. Evans,et al.  The pathogenesis of osteoarthritis of the hip. Evidence for primary osteocyte death. , 1987, Clinical orthopaedics and related research.

[200]  J. Reeve,et al.  The death of osteocytes via apoptosis accompanies estrogen withdrawal in human bone. , 1997, The Journal of clinical endocrinology and metabolism.

[201]  H J Donahue,et al.  Differential effect of steady versus oscillating flow on bone cells. , 1998, Journal of biomechanics.

[202]  J. Ward,et al.  MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover , 1999, Cell.

[203]  N Loveridge,et al.  Osteocyte density in aging subjects is enhanced in bone adjacent to remodeling haversian systems. , 2002, Bone.

[204]  L. Bonewald,et al.  Establishment of an Osteoid Preosteocyte‐like Cell MLO‐A5 That Spontaneously Mineralizes in Culture , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[205]  C. Palumbo A three-dimensional ultrastructural study of osteoid-osteocytes in the tibia of chick embryos , 2004, Cell and Tissue Research.

[206]  Richard O Hynes,et al.  Integrins Bidirectional, Allosteric Signaling Machines , 2002, Cell.

[207]  Yan Liu,et al.  Prevention of Glucocorticoid‐Induced Apoptosis in Osteocytes and Osteoblasts by Calbindin‐D28k , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.