CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not.

Recent immunogenetic studies of chronic lymphocytic leukemia (CLL) suggest a dichotomy: those developing from naive, pregerminal B lymphocytes exhibiting germline configuration of Ig VHstatus (poor outcome) and those stemming from more mature, postgerminal center memory B cells with mutated Ig

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