Molecular
patterns with nanoscale precision have been used to mimic
complex molecular networks. One key challenge in molecular patterns
is to perform active pattern operations in controllable systems to
fully imitate their complex dynamic behaviors. Here, we present a
reconfigurable DNA origami domino array-based dynamic pattern operation
(DODA DPO) system to perform proximity-induced molecular control for
complex pattern operations. The activatable platform of reconfigurable
DODA endows a spontaneous cascade of stacking conformational transformation
from the “before” to the “after” conformation
by a set of “trigger” DNA strands. The conformational
transformation further brings the operational pattern units into close
proximity to undergo DNA strand displacement cascades to accomplish
three different pattern operations of “writing”, “erasing”,
and “shifting”. Our results also demonstrate the reconfigurable
DODA DPO system provides a useful basis to study various molecular
control analysis in a fully programmable and controllable fashion.