Hereditary diffuse gastric cancer: translation of CDH1 germline mutations into clinical practice

[1]  H. Hoefler,et al.  Germline mutation of the E-cadherin gene in three sibling cases with advanced gastric cancer: clinical consequences for the other family members , 2010, European journal of gastroenterology & hepatology.

[2]  N. den Elzen,et al.  Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia. , 2009, Molecular biology of the cell.

[3]  P. Guilford,et al.  Hereditary diffuse gastric cancer: A manifestation of lost cell polarity , 2009, Cancer science.

[4]  J. Yokota,et al.  Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. , 2009, Gastroenterology.

[5]  S. Clark.  A Guide to Cancer Genetics in Clinical Practice , 2009 .

[6]  R. Seruca,et al.  E-cadherin mutations and cell motility: a genotype-phenotype correlation. , 2009, Experimental cell research.

[7]  S. Ghaffari,et al.  Novel human pathological mutations. Gene symbol: CDH1. Disease: gastric cancer. , 2009, Human genetics.

[8]  P. Guilford,et al.  E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man. , 2009, Cancer research.

[9]  S. Chin,et al.  Germline CDH1 deletions in hereditary diffuse gastric cancer families , 2009, Human molecular genetics.

[10]  F. van Roy,et al.  Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer. , 2008, Human molecular genetics.

[11]  C. Caldas,et al.  Histopathological and molecular analysis of gastrectomy specimens from hereditary diffuse gastric cancer patients has implications for endoscopic surveillance of individuals at risk , 2008, The Journal of pathology.

[12]  Yoko Ito,et al.  Mechanisms and sequelae of E‐cadherin silencing in hereditary diffuse gastric cancer , 2008, The Journal of pathology.

[13]  Matthew B. Wilson,et al.  Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers , 2008, Proceedings of the National Academy of Sciences.

[14]  A. Sézeur,et al.  Usefulness of Prophylactic Gastrectomy in a Novel Large Hereditary Diffuse Gastric Cancer (HDGC) Family , 2008, The American Journal of Gastroenterology.

[15]  R. Jeffrey,et al.  Risk-reducing Total Gastrectomy for Germline Mutations in E-cadherin (CDH1): Pathologic Findings With Clinical Implications , 2008, The American journal of surgical pathology.

[16]  T. Merriman,et al.  A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population , 2008, BMC Cancer.

[17]  Janine Senz,et al.  Hereditary diffuse gastric cancer: association with lobular breast cancer , 2007, Familial Cancer.

[18]  S. Ishikawa,et al.  Differential expression of basement membrane type IV collagen α chains in gastric intramucosal neoplastic lesions , 2007, Journal of Gastroenterology.

[19]  C. Vaccaro,et al.  Cáncer gástrico difuso hereditario (CGDH): presentación de una familia con una nueva mutación del gen CDH1 , 2007 .

[20]  Xi C. He,et al.  Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice. , 2007, Cancer research.

[21]  P. Miron,et al.  Germline E-cadherin mutations in familial lobular breast cancer , 2007, Journal of Medical Genetics.

[22]  B. Fernandez,et al.  Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. , 2007, JAMA.

[23]  R. Jeffrey,et al.  CDH1 Truncating Mutations in the E-Cadherin Gene: An Indication for Total Gastrectomy to Treat Hereditary Diffuse Gastric Cancer , 2007, Annals of surgery.

[24]  F. Roviello,et al.  Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family. , 2007, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[25]  A. Reeve,et al.  Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. , 2007, Cancer research.

[26]  B. Boman,et al.  Identification of seven novel germline mutations in the human E‐cadherin (CDH1) Gene , 2007, Human mutation.

[27]  D. Huntsman,et al.  [Hereditary diffuse gastric cancer (HDGC): presentation of a family with a new mutation of the CDH1 gene]. , 2007, Acta gastroenterologica Latinoamericana.

[28]  D. Weaver,et al.  Prophylactic Laparoscopic-Assisted Total Gastrectomy for Hereditary Diffuse Gastric Cancer , 2007, JSLS : Journal of the Society of Laparoendoscopic Surgeons.

[29]  C. Caldas,et al.  A novel mutation in the E-cadherin gene in the first family with hereditary diffuse gastric cancer reported in Spain. , 2006, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[30]  D. Huntsman,et al.  CDH1/E-cadherin germline mutations in early-onset gastric cancer , 2006, Journal of Medical Genetics.

[31]  I. Winship,et al.  Hereditary diffuse gastric cancer: diagnosis and management. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[32]  P. Lewis.  Novel human pathological mutations  , 2006, Human Genetics.

[33]  D. Huntsman,et al.  Characterization of a Recurrent Germ Line Mutation of the E-Cadherin Gene: Implications for Genetic Testing and Clinical Management , 2005, Clinical Cancer Research.

[34]  M Vekemans,et al.  Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer , 2005, Journal of Medical Genetics.

[35]  P. Guilford,et al.  Giant gastric ulcer: an endoscopic roller coaster , 2005, Gut.

[36]  Y. Wan,et al.  [Germline E-cadherin gene mutation screening in familial gastric cancer kindreds]. , 2004, Zhonghua wai ke za zhi [Chinese journal of surgery].

[37]  W. Foulkes,et al.  Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria , 2004, Journal of Medical Genetics.

[38]  C. Caldas,et al.  Model of the early development of diffuse gastric cancer in E‐cadherin mutation carriers and its implications for patient screening , 2004, The Journal of pathology.

[39]  H. Höfler,et al.  Germline mutations of the E-cadherin(CDH1) and TP53 genes, rather than of RUNX3 and HPP1, contribute to genetic predisposition in German gastric cancer patients , 2004, Journal of Medical Genetics.

[40]  T. Lehnert,et al.  Techniques of reconstruction after total gastrectomy for cancer , 2004, The British journal of surgery.

[41]  I. Christensen,et al.  Duodenal adenomatosis in familial adenomatous polyposis , 2004, Gut.

[42]  P. Guilford,et al.  Hereditary diffuse gastric cancer: predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone , 2003, Gut.

[43]  M. Fukuda,et al.  Cell proliferation and differentiation in intramucosal and advanced signet ring cell carcinomas of the human stomach , 2004, Virchows Archiv A.

[44]  C. P. Leblond,et al.  Defining Epithelial Cell Progenitors in the Human Oxyntic Mucosa , 2003, Stem cells.

[45]  P. Devilee,et al.  Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene , 2003, Genes, chromosomes & cancer.

[46]  Carla Oliveira,et al.  Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. , 2003, Human molecular genetics.

[47]  J. Yokota,et al.  Ile-Leu substitution (I415L) in germline E-cadherin gene (CDH1) in Japanese familial gastric cancer. , 2003, Japanese journal of clinical oncology.

[48]  T. Merriman,et al.  Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer , 2002, Oncogene.

[49]  J. Yokota,et al.  E‐cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer , 2002, International journal of cancer.

[50]  L. Aaltonen,et al.  Screening E‐cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred , 2002, Human mutation.

[51]  T. Merriman,et al.  Novel germline CDH1 mutations in hereditary diffuse gastric cancer families , 2002, Human mutation.

[52]  H. Grönberg,et al.  Germline mutations in E‐cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer , 2002, International journal of cancer.

[53]  Y. Bellaïche,et al.  Drosophila E-Cadherin Regulates the Orientation of Asymmetric Cell Division in the Sensory Organ Lineage , 2002, Current Biology.

[54]  W. Hyung,et al.  Early gastric carcinoma with signet ring cell histology , 2002, Cancer.

[55]  C Caldas,et al.  Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. , 2001, Gastroenterology.

[56]  C. Caldas,et al.  Prophylactic total gastrectomy for familial gastric cancer. , 2001, Surgery.

[57]  I. Tomlinson,et al.  Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age , 2001, Gut.

[58]  C. Caldas,et al.  Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. , 2001, The New England journal of medicine.

[59]  J. Raoul,et al.  A new mutation of E-cadherin gene in familial gastric linitis plastica cancer with extra-digestive dissemination. , 2001, European journal of gastroenterology & hepatology.

[60]  W. Wood,et al.  Oxford textbook of surgery , 2000 .

[61]  J. Yokota,et al.  Familial gastric cancer: overview and guidelines for management* , 1999, Journal of medical genetics.

[62]  B. Liedman.  Symptoms after total gastrectomy on food intake, body composition, bone metabolism, and quality of life in gastric cancer patients--is reconstruction with a reservoir worthwhile? , 1999, Nutrition.

[63]  H. Höfler,et al.  Diffuse type gastric and lobular breast carcinoma in a familial gastric cancer patient with an E-cadherin germline mutation. , 1999, The American journal of pathology.

[64]  J. Yokota,et al.  Familial gastric cancer: clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations. , 1999, Carcinogenesis.

[65]  J. Ku,et al.  Germline mutations of E-cadherin gene in Korean familial gastric cancer patients , 1999, Journal of Human Genetics.

[66]  D. Evans,et al.  Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. , 1999, Human molecular genetics.

[67]  S. Markowitz,et al.  E‐cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer , 1999, Human mutation.

[68]  H. Höfler,et al.  Identification of eleven novel tumor‐associated e‐cadherin mutations , 1999, Human mutation.

[69]  Kylie L. Gorringe,et al.  Identification of germ-line E-cadherin mutations in gastric cancer families of European origin. , 1998, Cancer research.

[70]  T. Yamaguchi,et al.  Characterization of signet ring cell carcinoma of the stomach , 1998, Journal of surgical oncology.

[71]  Anthony E. Reeve,et al.  E-cadherin germline mutations in familial gastric cancer , 1998, Nature.

[72]  Heinz Höfler,et al.  Mutations of the human E‐cadherin (CDH1) gene , 1998, Human mutation.

[73]  A. Axon,et al.  Early gastric cancer in Europe , 1997, Gut.

[74]  H. Yang,et al.  Prognostic significance of signet ring cell carcinoma of the stomach. , 1994, Surgical oncology.

[75]  Y. Maehara,et al.  Signet ring cell carcinoma of the stomach , 1992, Cancer.

[76]  M. Endo,et al.  Duration of ENNG administration and its effect on histological differentiation of experimental gastric cancer. , 1985, British Journal of Cancer.

[77]  J. Ward,et al.  Intestinal tumors in mice treated with a single injection of N-nitroso-N-butylurea. , 1975, Cancer research.

[78]  P. Laurén,et al.  THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. , 1965, Acta pathologica et microbiologica Scandinavica.

[79]  Jones Eg.  FAMILIAL GASTRIC CANCER. , 1964, The New Zealand medical journal.

[80]  M. M. Zinninger,et al.  Familial gastric cancer. , 1953, Gastroenterology.

[81]  S. Truelove,et al.  Carcinoma of the Stomach , 1952, British medical journal.

[82]  J. Hamner.  Carcinoma of the stomach. , 1952, Southern medicine and surgery.