Retinal microcirculation in patients with diabetes mellitus: dynamic and morphological analysis of perifoveal capillary network.

The new scanning laser technique allows one to quantify the retinal microcirculation. A digital image analysing system was used to study capillary blood flow velocities and morphological parameters of perifoveal intercapillary areas and foveal avascular zones in normal and diabetic subjects. Diabetic patients showed a significant reduction in capillary blood cell velocities in comparison with normal subjects. Perifoveal intercapillary areas and foveal avascular zones were significantly increased in all stages of diabetic retinopathy, and both parameters increased with progressing diabetic retinopathy. Significant changes in the perifoveal intercapillary areas were observed between normal subjects and patients with no retinopathy.

[1]  Stephen J. Aldington,et al.  Diabetic retinopathy: II. Assessment of severity and progression from fluorescein angiograms. , 1988, The Journal of diabetic complications.

[2]  L. Jampol,et al.  Ocular Pathology: Clinical Applications and Self-Assessment , 1985 .

[3]  M. Reim,et al.  Zur Quantifizierung der retinalen Kapillardurchblutung mit Hilfe des Scanning-Laser-Öphthalmoskops - Retinal Capillary Bloodflow Measurement by Means of a Scanning Laser Ophthalmoscope , 1990 .

[4]  M. Reim,et al.  Microcirculation in the conjunctival capillaries of healthy and hypertensive patients. , 1986, Klinische Wochenschrift.

[5]  A. Yoshida,et al.  Retinal blood flow alterations during progression of diabetic retinopathy. , 1983, Archives of ophthalmology.

[6]  J. Ostergren,et al.  Vital capillary microscopy for assessment of skin viability and microangiopathy in patients with diabetes mellitus. , 2009, Acta medica Scandinavica. Supplementum.

[7]  R. Webb,et al.  Confocal scanning laser ophthalmoscope. , 1987, Applied optics.

[8]  J. Gilchrist,et al.  PSYCHOPHYSICAL MEASUREMENT OF THE FOVEAL AVASCULAR ZONE * , 1987, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[9]  R. Engerman,et al.  Pathogenesis of Diabetic Retinopathy , 1989, Diabetes.

[10]  M Palta,et al.  Abnormalities of the foveal avascular zone in diabetic retinopathy. , 1984, Archives of ophthalmology.

[11]  E. Kohner.  The problems of retinal blood flow in diabetes. , 1976, Diabetes.

[12]  C. Riva,et al.  Prolongation of the retinal mean circulation time in diabetes. , 1982, Archives of ophthalmology.

[13]  [Retinal circulation time in diabetic retinopathy treated with photocoagulation (author's transl)]. , 1978, Klinische Monatsblatter fur Augenheilkunde.

[14]  S. Holm.  A Simple Sequentially Rejective Multiple Test Procedure , 1979 .

[15]  Kohner Em.  The problems of retinal blood flow in diabetes. , 1976 .

[16]  E M Kohner,et al.  Long-term follow-up of retinal blood flow in diabetes using the blue light entoptic phenomenon. , 1989, The British journal of ophthalmology.

[17]  C E Riva,et al.  Retinal vascular autoregulation in diabetes mellitus. , 1982, Ophthalmology.

[18]  T. Ishibashi,et al.  Reflow of obstructed capillaries in the maculae of humans with diabetic retinopathy, observed by fluorescein angiography. , 1988, The British journal of ophthalmology.

[19]  J Bille,et al.  Digital laser scanning fundus camera. , 1987, Applied optics.

[20]  E. Kohner,et al.  The effect of acute hyperglycemia on flow velocity in the macular capillaries. , 1987, Investigative ophthalmology & visual science.

[21]  F. Jung,et al.  Zur Methodik der Videokapillarmikroskopie: Bestimmung geometrischer und dynamischer Meßparameter - Video Capillary Microscopy: Determination of Geometrical and Dynamic Parameters , 1987 .

[22]  B L Petrig,et al.  Laser Doppler velocimetry study of retinal circulation in diabetes mellitus. , 1986, Archives of ophthalmology.

[23]  N. Ashton.  Vascular basement membrane changes in diabetic retinopathy. Montgomery lecture, 1973. , 1974, The British journal of ophthalmology.

[24]  B. Petrig,et al.  Effect of pure O2-breathing on retinal blood flow in normals and in patients with background diabetic retinopathy. , 1984, Current eye research.

[25]  H. Oswald,et al.  [Measurement of flow physiology of the large vessels in retinal circulation in type 1 and type 2 diabetics]. , 1983, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.

[26]  J. Gundersen,et al.  Capillary blood flow in the nail fold in relation to the digital systolic blood pressure. , 1975, VASA. Zeitschrift fur Gefasskrankheiten.