“Hypothesis of Seven Balances”: Molecular Mechanisms behind Alcoholic Liver Diseases and Association with PPARα
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[1] Michael Müller,et al. Peroxisome Proliferator-Activated Receptor Alpha Target Genes , 2010, PPAR research.
[2] X. D. Wang. Chronic alcohol intake interferes with retinoid metabolism and signaling. , 2009, Nutrition reviews.
[3] C. Lieber,et al. An experimental model of alcohol feeding and liver injury in the baboon. , 2009, Journal of medical primatology.
[4] M. Pinzani,et al. Reversal of Liver Fibrosis , 2009, Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association.
[5] A. Baker. Alcohol-related deaths by occupation: what do data for England and Wales in 2001-2005 tell us about doctors' mortality? , 2008, Alcohol and alcoholism.
[6] H. Tsukamoto,et al. Fat paradox of steatohepatitis , 2008, Journal of gastroenterology and hepatology.
[7] Jordi Muntané,et al. Mecanismos de lesión hepatocelular , 2007 .
[8] K. Wolski,et al. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. , 2007, The New England journal of medicine.
[9] S. Nissen,et al. Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials. , 2007, JAMA.
[10] P. Froguel,et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions , 2007, Nature Medicine.
[11] N. Müller,et al. Sustained JNK Activation in Response to Tumor Necrosis Factor Is Mediated by Caspases in a Cell Type-specific Manner* , 2007, Journal of Biological Chemistry.
[12] S. Friedman,et al. Hepatic fibrosis 2006: Report of the third AASLD Single Topic Conference , 2007, Hepatology.
[13] S. Friedman. Transcriptional regulation of stellate cell activation , 2006, Journal of gastroenterology and hepatology.
[14] T. Luedde,et al. Evaluation of the role of nuclear factor‐κB signaling in liver injury using genetic animal models , 2006, Journal of gastroenterology and hepatology.
[15] Q. Zhai,et al. Alcohol‐induced oxidative stress and cell responses , 2006, Journal of gastroenterology and hepatology.
[16] A. Cederbaum. Cytochrome P450 2E1‐dependent oxidant stress and upregulation of anti‐oxidant defense in liver cells , 2006, Journal of gastroenterology and hepatology.
[17] P. Park,et al. Regulation of Kupffer cell activity during chronic ethanol exposure: Role of adiponectin , 2006, Journal of gastroenterology and hepatology.
[18] David A. Brenner,et al. Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways , 2006 .
[19] T. Noda,et al. Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways* , 2006, Journal of Biological Chemistry.
[20] M. Kamijima,et al. A review of hazardous chemical toxicity studies utilizing genetically-modified animals--their applications for risk assessment. , 2005, Industrial health.
[21] F. Oakley,et al. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis , 2005, Apoptosis.
[22] W. Bensch,et al. Identification of a Novel Selective Peroxisome Proliferator-Activated Receptor α Agonist, 2-Methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl]propyl}phenoxy)propanoic Acid (LY518674), That Produces Marked Changes in Serum Lipids and Apolipoprotein A-1 Expression , 2005, Molecular Pharmacology.
[23] D. Crabb,et al. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice , 2005, Hepatology.
[24] J. Auwerx,et al. PPARα downregulates airway inflammation induced by lipopolysaccharide in the mouse , 2005, Respiratory research.
[25] F. Anania,et al. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. , 2005, The American journal of pathology.
[26] Y. Matsuzawa. Adiponectin: Identification, physiology and clinical relevance in metabolic and vascular disease. , 2005, Atherosclerosis. Supplements.
[27] A. Ganesan,et al. Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity , 2005, Apoptosis.
[28] T. Kadowaki. [Recent advances in PPARs research--basic and clinical aspects]. , 2005, Nihon rinsho. Japanese journal of clinical medicine.
[29] H. Fujii. [Anti-inflammatory action of PPARs]. , 2005, Nihon rinsho. Japanese journal of clinical medicine.
[30] J. Doyle,et al. Metabolic syndrome and robustness tradeoffs. , 2004, Diabetes.
[31] Yuichi Harano,et al. PPARα ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats , 2004 .
[32] J. Peters,et al. Peroxisome proliferator‐activated receptor α protects against alcohol‐induced liver damage , 2004 .
[33] J. Peters,et al. Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. , 2004, Hepatology.
[34] C. McClain,et al. Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease. , 2004, American journal of physiology. Gastrointestinal and liver physiology.
[35] L. Romics,et al. Diverse regulation of NF‐κB and peroxisome proliferator‐activated receptors in murine nonalcoholic fatty liver , 2004, Hepatology.
[36] C. Lieber,et al. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. , 2004, Alcohol.
[37] M. Wheeler,et al. Recent advances in alcoholic liver disease III. Role of the innate immune response in alcoholic hepatitis. , 2004, American journal of physiology. Gastrointestinal and liver physiology.
[38] P. Froguel,et al. Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity* , 2004, Journal of Biological Chemistry.
[39] M. Czaja. Liver injury in the setting of steatosis: Crosstalk between adipokine and cytokine , 2004, Hepatology.
[40] D. Crabb,et al. Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver. , 2004, American journal of physiology. Gastrointestinal and liver physiology.
[41] H. Yoshimatsu,et al. Adiponectin protects LPS‐induced liver injury through modulation of TNF‐α in KK‐Ay obese mice , 2004 .
[42] R. Rao,et al. Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. , 2004, American journal of physiology. Gastrointestinal and liver physiology.
[43] S. Kersten,et al. Peroxisome proliferator-activated receptor α target genes , 2004, Cellular and Molecular Life Sciences CMLS.
[44] S. Kihara,et al. Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. , 2003, Gastroenterology.
[45] S. Kihara,et al. Obesity, adiponectin and vascular inflammatory disease , 2003, Current opinion in lipidology.
[46] S. Zolotukhin,et al. Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[47] R. Groszmann,et al. I. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease: effects on drinking behavior by nurse/physician teams. , 2003, Alcoholism, clinical and experimental research.
[48] R. Groszmann,et al. II. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease. , 2003, Alcoholism, clinical and experimental research.
[49] L. Nagy. Recent Insights into the Role of the Innate Immune System in the Development of Alcoholic Liver Disease , 2003, Experimental biology and medicine.
[50] D. Brenner,et al. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. , 2003, Journal of hepatology.
[51] Yu Wang,et al. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. , 2003, The Journal of clinical investigation.
[52] Philippe Froguel,et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects , 2003, Nature.
[53] C. McClain,et al. Prevention of Alterations in Intestinal Permeability Is Involved in Zinc Inhibition of Acute Ethanol-Induced Liver Damage in Mice , 2003, Journal of Pharmacology and Experimental Therapeutics.
[54] G. Gores,et al. Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic , 2003, Laboratory Investigation.
[55] P. Whittaker,et al. PPAR‐α and ‐γ but not ‐δ agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF‐κB‐independent effect , 2003 .
[56] G. Su,et al. Activation of human and mouse Kupffer cells by lipopolysaccharide is mediated by CD14. , 2002, American journal of physiology. Gastrointestinal and liver physiology.
[57] G. Su,et al. Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. , 2002, American journal of physiology. Gastrointestinal and liver physiology.
[58] M. Salaspuro,et al. Microbes and mucosa in the regulation of intracolonic acetaldehyde concentration during ethanol challenge. , 2002, Alcohol and alcoholism.
[59] R. Gamelli,et al. Gut-associated lymphoid T cell suppression enhances bacterial translocation in alcohol and burn injury. , 2002, American journal of physiology. Gastrointestinal and liver physiology.
[60] G. Arteel,et al. Role of Lipopolysaccharide-Binding Protein in Early Alcohol-Induced Liver Injury in Mice1 , 2002, The Journal of Immunology.
[61] I. Rusyn,et al. The role of Kupffer cell oxidant production in early ethanol-induced liver disease. , 2001, Free radical biology & medicine.
[62] G. Su,et al. Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines. , 2001, American journal of physiology. Gastrointestinal and liver physiology.
[63] A. Keshavarzian,et al. Preventing gut leakiness by oats supplementation ameliorates alcohol-induced liver damage in rats. , 2001, The Journal of pharmacology and experimental therapeutics.
[64] I. Rusyn,et al. Alcohol‐induced free radicals in mice: Direct toxicants or signaling molecules? , 2001, Hepatology.
[65] M. Karin,et al. Signal transduction by tumor necrosis factor and its relatives. , 2001, Trends in cell biology.
[66] P. Scherer,et al. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action , 2001, Nature Medicine.
[67] R. Rao,et al. Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions. , 2001, American journal of physiology. Gastrointestinal and liver physiology.
[68] I. Rusyn,et al. Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats. , 2001, Gastroenterology.
[69] R. McCuskey,et al. Endotoxin, endotoxin-neutralizing-capacity, sCD14, sICAM-1, and cytokines in patients with various degrees of alcoholic liver disease. , 2001, Alcoholism, clinical and experimental research.
[70] D. Crabb,et al. The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver. , 2001, The Journal of biological chemistry.
[71] D. Crabb,et al. The Transcriptional and DNA Binding Activity of Peroxisome Proliferator-activated Receptor α Is Inhibited by Ethanol Metabolism , 2001, The Journal of Biological Chemistry.
[72] Y. Liaw,et al. Constitutive activation of nuclear factor κB in hepatocellular carcinoma , 2000 .
[73] B. Staels,et al. Induction of IκBα Expression as a Mechanism Contributing to the Anti-inflammatory Activities of Peroxisome Proliferator-activated Receptor-α Activators* , 2000, The Journal of Biological Chemistry.
[74] H. Tilg,et al. Cytokines in alcoholic and nonalcoholic steatohepatitis. , 2000, The New England journal of medicine.
[75] A. Keshavarzian,et al. Exacerbation of alcoholic liver injury by enteral endotoxin in rats , 2000, Hepatology.
[76] M. Manns,et al. Tumor necrosis factor α in the pathogenesis of human and murine fulminant hepatic failure , 2000 .
[77] B. Ahluwalia,et al. Alcohol modulates cytokine secretion and synthesis in human fetus: an in vivo and in vitro study. , 2000, Alcohol.
[78] Sander Kersten,et al. Roles of PPARs in health and disease , 2000, Nature.
[79] C. Bode,et al. Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. , 2000, Journal of hepatology.
[80] G. Gores,et al. Apoptosis and liver disease. , 2000, The American journal of medicine.
[81] K. Hoppo,et al. Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbance. , 2000, Alcoholism, clinical and experimental research.
[82] I. Rusyn,et al. Gender differences in early alcohol-induced liver injury: role of CD14, NF-κB, and TNF-α , 2000 .
[83] Y. Liaw,et al. Activation of nuclear factor κB in hepatitis C virus infection: Implications for pathogenesis and hepatocarcinogenesis , 2000, Hepatology.
[84] S. Friedman. Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury* , 2000, The Journal of Biological Chemistry.
[85] F. Piscaglia,et al. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. , 1999, Gastroenterology.
[86] M. Luster,et al. Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice , 1999 .
[87] P. Libby,et al. PPARα Activators Inhibit Cytokine-Induced Vascular Cell Adhesion Molecule-1 Expression in Human Endothelial Cells , 1999 .
[88] J. Rodés,et al. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. , 1999, Journal of hepatology.
[89] C. Lieber,et al. Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system. , 1998, Alcoholism, clinical and experimental research.
[90] M. Singer,et al. Presence of plasma endotoxin is correlated with tumour necrosis factor receptor levels and disease activity in alcoholic cirrhosis. , 1998, Alcohol and alcoholism.
[91] R. Thurman,et al. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. , 1998, American Journal of Physiology - Gastrointestinal and Liver Physiology.
[92] S. Gordon,et al. Recognizing death: the phagocytosis of apoptotic cells. , 1998, Trends in cell biology.
[93] W. Koenig,et al. Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators , 1998, Nature.
[94] R. Batey,et al. Decreased Tumor Necrosis Factor‐α and Interleukin‐1α Production from Intrahepatic Mononuclear Cells in Chronic Ethanol Consumption and Upregulation by Endotoxin , 1998 .
[95] M. Luster,et al. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat , 1997, Hepatology.
[96] M. Salaspuro,et al. Microbial metabolism of ethanol and acetaldehyde and clinical consequences , 1997, Addiction biology.
[97] M. Salaspuro. Bacteriocolonic pathway for ethanol oxidation: characteristics and implications. , 1996, Annals of medicine.
[98] Philipp E. Scherer,et al. A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes (*) , 1995, The Journal of Biological Chemistry.
[99] D. Bunout,et al. Effects of long-term vitamin E supplementation in alcoholic cirrhotics. , 1995, Journal of the American College of Nutrition.
[100] Y. Wan,et al. Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease. , 1994, Life sciences.
[101] A. Keshavarzian,et al. The differing effects of acute and chronic alcohol on gastric and intestinal permeability. , 1994, The American journal of gastroenterology.
[102] A. Nanji,et al. Lactobacillus Feeding Reduces Endotoxemia and Severity of Experimental Alcoholic Liver (Disease) , 1994, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[103] N. Sheron,et al. Circulating and tissue levels of the neutrophil chemotaxin interleukin‐8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration , 1993, Hepatology.
[104] A. Nanji,et al. Severity of liver injury in experimental alcoholic liver disease. Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4, and thromboxane B2. , 1993, The American journal of pathology.
[105] A. Rosman,et al. Induction of cytochrome P‐4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA , 1993, Hepatology.
[106] C. Lieber. Alcoholic liver injury , 1992 .
[107] C. McClain,et al. Increased plasma interleukin-6 concentrations in alcoholic hepatitis. , 1992, The Journal of laboratory and clinical medicine.
[108] C. McClain. Tumor necrosis and alcoholic hepatitis Bird GLA, Sheron N, Goka AKJ, Alexander GJ, Williams RS. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med 1990;112:917–920 , 1991 .
[109] C. Bode,et al. Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay. , 1991, Journal of hepatology.
[110] F. Fiaccadori,et al. Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study. , 1990, Gastroenterology.
[111] G. Alexander,et al. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. , 1990, Annals of internal medicine.
[112] R. Veech,et al. Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis. , 1990, Alcoholism, clinical and experimental research.
[113] A. Rosman,et al. The intralobular distribution of ethanol‐inducible P450IIE1 in rat and human liver , 1989, Hepatology.
[114] T. Miller,et al. Effects of ethanol and prostaglandin on rat gastric mucosal tight junctions. , 1987, The Journal of surgical research.
[115] C. McClain,et al. Serum interleukin-1 (IL-1) activity in alcoholic hepatitis. , 1986, Life sciences.
[116] H. Tsukamoto,et al. Ethanol‐induced liver fibrosis in rats fed high fat diet , 1986, Hepatology.
[117] C. Lieber,et al. Quantitative relationship between amount of dietary fat and severity of alcoholic fatty liver. , 1970, The American journal of clinical nutrition.
[118] T. Tephly,et al. Alcohol Metabolism: Role of Microsomal Oxidation in vivo , 1969, Science.
[119] M. K. Roach,et al. Ethanol oxidation in the microsomal fraction of rat liver. , 1969, Biochemical and biophysical research communications.
[120] C. Lieber,et al. Difference in hepatic metabolism of long- and medium-chain fatty acids: the role of fatty acid chain length in the production of the alcoholic fatty liver. , 1967, The Journal of clinical investigation.
[121] C. Lieber,et al. EFFECTS OF PROLONGED ETHANOL INTAKE: PRODUCTION OF FATTY LIVER DESPITE ADEQUATE DIETS. , 1965, The Journal of clinical investigation.
[122] R. Schwabe,et al. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. , 2006, American journal of physiology. Gastrointestinal and liver physiology.
[123] C. J. Marek,et al. Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. , 2005, Gastroenterology.
[124] D. Grobbee,et al. Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity. , 2004, Diabetes care.
[125] M. Haluzík,et al. Adiponectin and its role in the obesity-induced insulin resistance and related complications. , 2004, Physiological research.
[126] D. Crabb,et al. Recent Advances in Alcoholic Liver Disease , 2004 .
[127] David R Ragland,et al. Burnout and alcohol problems among urban transit operators in San Francisco. , 2003, Addictive behaviors.
[128] P. Scheurich,et al. Tumor necrosis factor signaling , 2003, Cell Death and Differentiation.
[129] T. Awata,et al. The ligands/activators for peroxisome proliferator-activated receptor α (PPARα) and PPARγ increase Cu2+, Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells , 2001 .
[130] H. Flynn. Comparison of cross-sectional and daily reports in studying the relationship between depression and use of alcohol in response to stress in college students. , 2000, Alcoholism, clinical and experimental research.
[131] A. Keshavarzian,et al. Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage , 1999, American Journal of Gastroenterology.
[132] R. Thurman. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. , 1998, American Journal of Physiology.
[133] R. Thurman,et al. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. , 1995, Gastroenterology.
[134] C. Lieber. Medical and Nutritional Complications of Alcoholism , 1992, Springer US.