T1 measurements in the human myocardium: The effects of magnetization transfer on the SASHA and MOLLI sequences

Quantitative mapping of the native T1 of the heart using the modified look‐locker inversion recovery (MOLLI) technique provides high quality diagnostic information without requiring contrast agents. Previous work has considered the effects of T2 relaxation on MOLLI T1 measurements, finding that the T1 measured by MOLLI is biased, and that Saturation‐recovery single‐Shot Acquisition generates a more precise T1. However, despite detailed experiments and simulation the exact relaxation times observed in vivo remain unexplained, but might be due to magnetization transfer (MT).

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