Response to Comment on “Cathepsin-L Influences the Expression of Extracellular Matrix in Lymphoid Organs and Plays a Role in the Regulation of Thymic Output and of Peripheral T Cell Number”

In our article published in The Journal of Immunology in June 1, 2005 ([1][1]), we reported that lymph nodes from nackt mice ( CTSL nkt / CTSL nkt ) are hypertrophied, showing a normal absolute number of CD4+ T cells and a marked increase in the number of CD8+ T lymphocytes. Correlatively,

[1]  R. N. Brogden,et al.  Pentostatin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in lymphoproliferative disorders. , 1993, Drugs.

[2]  S. Rosenberg,et al.  Analysis of the Cellular Mechanism of Antitumor Responses and Autoimmunity in Patients Treated with CTLA-4 Blockade , 2005, The Journal of Immunology.

[3]  P. Bekinschtein,et al.  Cathepsin-L Influences the Expression of Extracellular Matrix in Lymphoid Organs and Plays a Role in the Regulation of Thymic Output and of Peripheral T Cell Number1 , 2005, The Journal of Immunology.

[4]  J. Aarseth,et al.  IL‐6: an early marker for outcome in acute ischemic stroke , 2005, Acta neurologica Scandinavica.

[5]  M. Eisenhut.  Comment on “Pretreatment Intracerebral and Peripheral Blood Immune Responses in Vietnamese Adults with Tuberculous Meningitis: Diagnostic Value and Relationship to Disease Severity and Outcome” , 2006, The Journal of Immunology.

[6]  A. Rudensky,et al.  Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. , 1998, Science.

[7]  R. Maciewicz,et al.  Cathepsin L‐deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy , 2004, International journal of experimental pathology.

[8]  K. Matsushima,et al.  Absence of IL-1 Receptor Antagonist Impaired Wound Healing along with Aberrant NF-κB Activation and a Reciprocal Suppression of TGF-β Signal Pathway1 , 2006, The Journal of Immunology.

[9]  N. Kohno,et al.  Interleukin 6 activity in pleural effusion. Its diagnostic value and thrombopoietic activity. , 1992, Chest.

[10]  J. Parrillo,et al.  Adenosine deaminase inhibition attenuates microvascular dysfunction and improves survival in sepsis. , 2002, American journal of respiratory and critical care medicine.

[11]  M. Willingham,et al.  Involvement of carboxy-terminal amino acids in secretion of human lysosomal protease cathepsin L. , 1998, Biochemistry.

[12]  J. Farrar,et al.  Pretreatment Intracerebral and Peripheral Blood Immune Responses in Vietnamese Adults with Tuberculous Meningitis: Diagnostic Value and Relationship to Disease Severity and Outcome , 2006, The Journal of Immunology.

[13]  M. Gottesman,et al.  Activity and deletion analysis of recombinant human cathepsin L expressed in Escherichia coli. , 1989, The Journal of biological chemistry.

[14]  S. Ho,et al.  Cerebral Infarcts Complicating Tuberculous Meningitis , 2005, Cerebrovascular Diseases.

[15]  T. Gallart,et al.  CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[16]  J. Guénet,et al.  The Radiation-Induced nackt (nkt) Allele Is a Loss-of-Function Mutation of the Mouse Cathepsin L Gene , 2006, Journal of Immunology.

[17]  M. Eisenhut,et al.  Cerebrospinal Fluid Adenosine Deaminase Levels and Adverse Neurological Outcome in Pediatric Tuberculous Meningitis , 2005, Infection.