Acute ethanol-induced changes in cerebral blood flow.

Using high-resolution single photon emission computed tomography, the authors studied changes in cerebral blood flow (CBF) in six healthy men after the men rapidly consumed intoxicating amounts of ethanol. When the subjects were given intravenous placebo before ethanol intake, regional CBF was significantly increased over baseline in the right prefrontal cortex, but no significant change in CBF was observed when the subjects received intravenous naloxone before ethanol intake. The results indicate that euphoria occurring during acute ethanol intake is associated with activation of the right prefrontal cortex and mediated through the endogenous opioid system.

[1]  L. D. Reid,et al.  Tests of opioid deficiency hypotheses of alcoholism. , 1991, Alcohol.

[2]  M. Salamero,et al.  Regional cerebral blood flow-SPECT in chronic alcoholism: relation to neuropsychological testing. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[3]  B. Rounsaville,et al.  Naltrexone and coping skills therapy for alcohol dependence. A controlled study. , 1992, Archives of general psychiatry.

[4]  F. F. Weight,et al.  Acute ethanol administration selectively alters localized cerebral glucose metabolism , 1988, Brain Research.

[5]  L. D. Reid,et al.  Morphine and naloxone modulate intake of ethanol. , 1984, Alcohol.

[6]  R A Holmes,et al.  Technetium-99 m d , l-HM-PAO : A New Rathopharmaceutical for SPECT Imaging of Regional CerebralBlood Perfusion , 2006 .

[7]  P T Fox,et al.  Neuroanatomical correlates of a lactate-induced anxiety attack. , 1989, Archives of general psychiatry.

[8]  A. Alterman,et al.  Naltrexone and the Treatment of Alcohol-Dependence: Initial Observations , 1990 .

[9]  W. Kuschinsky,et al.  Changes in local cerebral glucose utilization in the awake rat during acute and chronic administration of ethanol. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  M. Raichle,et al.  PET images of blood flow changes during anxiety: correction. , 1992, Science.

[11]  M E Raichle,et al.  The application of positron emission tomography to the study of panic disorder. , 1986, The American journal of psychiatry.

[12]  Nora D. Volkow,et al.  Effects of acute alcohol intoxication on cerebral blood flow measured with PET , 1988, Psychiatry Research.

[13]  Peter Herscovitch,et al.  A focal brain abnormality in panic disorder, a severe form of anxiety , 1984, Nature.

[14]  J. Kril,et al.  Neuropathology of alcoholism. , 1990, Alcohol and alcoholism.

[15]  M. Raichle,et al.  Neuroanatomical correlates of anticipatory anxiety. , 1989, Science.

[16]  M. Davis,et al.  Naltrexone blocks the post-shock increase of ethanol consumption. , 1986, Life sciences.

[17]  G D Pearlson,et al.  Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects. , 1993, The American journal of psychiatry.

[18]  L. Brass,et al.  New anatomical and functional imaging methods , 1992, Annals of neurology.

[19]  M. Tenhunen-Eskelinen,et al.  Physical performance of the Siemens MultiSPECT 3 gamma camera , 1993, Nuclear medicine communications.

[20]  R. Tarter,et al.  Multifactorial etiology of neuropsychological impairment in alcoholics. , 1986, Alcoholism, clinical and experimental research.