Use it or lose it: How neurogenesis keeps the brain fit for learning

[1]  J. Knott The organization of behavior: A neuropsychological theory , 1951 .

[2]  R. Morris,et al.  Place navigation impaired in rats with hippocampal lesions , 1982, Nature.

[3]  S. Bayer,et al.  Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life. , 1982, Science.

[4]  G. Paxinos The Rat nervous system , 1985 .

[5]  B. H. Bland The physiology and pharmacology of hippocampal formation theta rhythms , 1986, Progress in Neurobiology.

[6]  R. Morris,et al.  Distinct components of spatial learning revealed by prior training and NMDA receptor blockade , 1995, Nature.

[7]  J J Kim,et al.  Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses. , 1995, Behavioral neuroscience.

[8]  Richard F. Thompson,et al.  Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses. , 1995, Behavioral neuroscience.

[9]  W. Klimesch Memory processes, brain oscillations and EEG synchronization. , 1996, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[10]  L. Squire,et al.  Structure and function of declarative and nondeclarative memory systems. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[11]  G. Buzsáki,et al.  High-Frequency Oscillations in the Output Networks of the Hippocampal–Entorhinal Axis of the Freely Behaving Rat , 1996, The Journal of Neuroscience.

[12]  P. Milner,et al.  Preconceptions and prerequisites: Understanding the function of synaptic plasticity will also depend on a better systems-level understanding of the multiple types of memory , 1997, Behavioral and Brain Sciences.

[13]  R. Clark,et al.  Classical conditioning and brain systems: the role of awareness. , 1998, Science.

[14]  S. J. Martin,et al.  Reversible neural inactivation reveals hippocampal participation in several memory processes , 1999, Nature Neuroscience.

[15]  E. Gould,et al.  Learning enhances adult neurogenesis in the hippocampal formation , 1999, Nature Neuroscience.

[16]  E. Gould,et al.  Neurogenesis in the adult is involved in the formation of trace memories , 2001, Nature.

[17]  R. McKay,et al.  Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus , 2001, The Journal of comparative neurology.

[18]  Louis D. Matzel,et al.  The Role of the Hippocampus in Trace Conditioning: Temporal Discontinuity or Task Difficulty? , 2001, Neurobiology of Learning and Memory.

[19]  G. Buzsáki Theta Oscillations in the Hippocampus , 2002, Neuron.

[20]  E. Gould,et al.  Neurogenesis may relate to some but not all types of hippocampal‐dependent learning , 2002, Hippocampus.

[21]  Fernando Nottebohm,et al.  Neuronal replacement in adult brain , 2002, Brain Research Bulletin.

[22]  F. Gage,et al.  Functional neurogenesis in the adult hippocampus , 2002, Nature.

[23]  Tracey J. Shors,et al.  Associative Memory Formation Increases the Observation of Dendritic Spines in the Hippocampus , 2003, The Journal of Neuroscience.

[24]  T. Madsen,et al.  Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat , 2003, Neuroscience.

[25]  D. Abrous,et al.  Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Yutaka Kirino,et al.  Time-Dependent Reorganization of the Brain Components Underlying Memory Retention in Trace Eyeblink Conditioning , 2003, The Journal of Neuroscience.

[27]  E. Gould,et al.  Learning Enhances the Survival of New Neurons beyond the Time when the Hippocampus Is Required for Memory , 2004, The Journal of Neuroscience.

[28]  P. Jonas,et al.  Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus , 2004, Nature.

[29]  A. Shetty,et al.  Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus , 2004, The European journal of neuroscience.

[30]  G. Buzsáki,et al.  Neuronal Oscillations in Cortical Networks , 2004, Science.

[31]  T. Hisatsune,et al.  GABAergic Excitation Promotes Neuronal Differentiation in Adult Hippocampal Progenitor Cells , 2005, Neuron.

[32]  P. Fries A mechanism for cognitive dynamics: neuronal communication through neuronal coherence , 2005, Trends in Cognitive Sciences.

[33]  G. Buzsáki,et al.  Interaction between neocortical and hippocampal networks via slow oscillations. , 2005, Thalamus & related systems.

[34]  G. Westbrook,et al.  GABAergic signaling to newborn neurons in dentate gyrus. , 2005, Journal of neurophysiology.

[35]  H. Cameron,et al.  A natural form of learning can increase and decrease the survival of new neurons in the dentate gyrus , 2005, Hippocampus.

[36]  J. Lisman,et al.  Hippocampal sequence-encoding driven by a cortical multi-item working memory buffer , 2005, Trends in Neurosciences.

[37]  R. J. McDonald,et al.  A role for adult neurogenesis in spatial long-term memory , 2005, Neuroscience.

[38]  S. Becker A computational principle for hippocampal learning and neurogenesis , 2005, Hippocampus.

[39]  E. Rolls,et al.  A computational theory of hippocampal function, and empirical tests of the theory , 2006, Progress in Neurobiology.

[40]  E. Gould,et al.  Temporal Discontiguity Is neither Necessary nor Sufficient for Learning-Induced Effects on Adult Neurogenesis , 2006, The Journal of Neuroscience.

[41]  Chunmei Zhao,et al.  Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus , 2006, The Journal of Neuroscience.

[42]  Fred H. Gage,et al.  NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus , 2006, Nature.

[43]  Jason S. Snyder,et al.  Inhibition of neurogenesis interferes with hippocampus‐dependent memory function , 2006, Hippocampus.

[44]  E. Kandel,et al.  Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus , 2006, Proceedings of the National Academy of Sciences.

[45]  G. Westbrook,et al.  Delayed Development of Adult-Generated Granule Cells in Dentate Gyrus , 2006, The Journal of Neuroscience.

[46]  T. Shors,et al.  Trace Conditioning and the Hippocampus: The Importance of Contiguity , 2006, The Journal of Neuroscience.

[47]  G. Buzsáki Rhythms of the brain , 2006 .

[48]  G. Mckhann GABA Regulates Synaptic Integration of Newly Generated Neurons in the Adult Brain. , 2006, Neurosurgery.

[49]  Elizabeth Gould,et al.  Is there a link between adult neurogenesis and learning? , 2006, Hippocampus.

[50]  Laurenz Wiskott,et al.  A functional hypothesis for adult hippocampal neurogenesis: Avoidance of catastrophic interference in the dentate gyrus , 2006, Hippocampus.

[51]  Chunmei Zhao,et al.  Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus , 2006, PLoS biology.

[52]  C. Rampon,et al.  Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus , 2006, The Journal of Neuroscience.

[53]  D. Abrous,et al.  Learning-Induced Survival of New Neurons Depends on the Cognitive Status of Aged Rats , 2007, The Journal of Neuroscience.

[54]  T. Shors,et al.  Neurogenesis and the spacing effect: learning over time enhances memory and the survival of new neurons. , 2007, Learning & memory.

[55]  S. Ge,et al.  A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain , 2007, Neuron.

[56]  O. Witte,et al.  Effects of Skilled Forelimb Training on Hippocampal Neurogenesis and Spatial Learning After Focal Cortical Infarcts in the Adult Rat Brain , 2007, Stroke.

[57]  David Dupret,et al.  Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons , 2007, PLoS biology.

[58]  Afra H. Wang,et al.  Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus , 2007, Nature Neuroscience.

[59]  Mark Ellisman,et al.  Synapse formation on neurons born in the adult hippocampus , 2007, Nature Neuroscience.

[60]  T. Shors,et al.  Neurogenesis and learning: Acquisition and asymptotic performance predict how many new cells survive in the hippocampus , 2007, Neurobiology of Learning and Memory.

[61]  J. Epp,et al.  Hippocampus-dependent learning promotes survival of new neurons in the dentate gyrus at a specific time during cell maturation , 2007, Neuroscience.

[62]  T. Shors,et al.  From stem cells to grandmother cells: how neurogenesis relates to learning and memory. , 2008, Cell stem cell.

[63]  T. Shors,et al.  Neurogenesis, learning and associative strength , 2008, The European journal of neuroscience.

[64]  Gordon Winocur,et al.  The effects of running and of inhibiting adult neurogenesis on learning and memory in rats , 2008, The European journal of neuroscience.

[65]  A. Bacci,et al.  The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory , 2008, PLoS biology.

[66]  F. Gage,et al.  Neurons born in the adult dentate gyrus form functional synapses with target cells , 2008, Nature Neuroscience.

[67]  S. Toshkov,et al.  Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice , 2008, Neuroscience.

[68]  Sean M Montgomery,et al.  Entrainment of Neocortical Neurons and Gamma Oscillations by the Hippocampal Theta Rhythm , 2008, Neuron.

[69]  J. Born,et al.  Sustained increase in hippocampal sharp-wave ripple activity during slow-wave sleep after learning. , 2008, Learning & memory.

[70]  Fred H. Gage,et al.  A role for adult TLX-positive neural stem cells in learning and behaviour , 2008, Nature.

[71]  G. Buzsáki,et al.  A neural coding scheme formed by the combined function of gamma and theta oscillations. , 2008, Schizophrenia bulletin.

[72]  Ryoichiro Kageyama,et al.  Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain , 2008, Nature Neuroscience.

[73]  New hippocampal neurons are not obligatory for memory formation:mice with no adult brain neurogenesis show learning , 2009 .

[74]  J. Canales,et al.  Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and spatial reversal , 2009, Neuroscience.

[75]  F. Gage,et al.  Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain , 2009, The Journal of Neuroscience.

[76]  T. Shors,et al.  Saving new brain cells. , 2009, Scientific American.

[77]  Abrous Nora Spatial relational memory requires hippocampal adult neurogenesis , 2009 .

[78]  S. Trouche,et al.  Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory , 2009, Proceedings of the National Academy of Sciences.

[79]  G. Buzsáki,et al.  Selective suppression of hippocampal ripples impairs spatial memory , 2009, Nature Neuroscience.

[80]  Takashi Kitamura,et al.  Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory , 2009, Cell.

[81]  D. Amaral,et al.  The Hippocampal Formation , 2009 .

[82]  T. Shors,et al.  Prozac during puberty: distinctive effects on neurogenesis as a function of age and sex , 2009, Neuroscience.

[83]  G. Kempermann,et al.  Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies , 2009, PloS one.

[84]  M. Fuss,et al.  Ionizing radiation impairs the formation of trace fear memories and reduces hippocampal neurogenesis. , 2009, Behavioral neuroscience.

[85]  Wolf Singer,et al.  Distributed processing and temporal codes in neuronal networks , 2009, Cognitive Neurodynamics.

[86]  L. Saksida,et al.  A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation , 2009, Science.

[87]  Jason S. Snyder,et al.  Adult-Born Hippocampal Neurons Are More Numerous, Faster Maturing, and More Involved in Behavior in Rats than in Mice , 2009, The Journal of Neuroscience.

[88]  T. Shors,et al.  Female rats learn trace memories better than male rats and consequently retain a greater proportion of new neurons in their hippocampi , 2009, Proceedings of the National Academy of Sciences.

[89]  M. Penttonen,et al.  Hippocampal theta-band activity and trace eyeblink conditioning in rabbits. , 2009, Behavioral neuroscience.

[90]  W. Singer,et al.  Neural Synchrony in Cortical Networks: History, Concept and Current Status , 2009, Front. Integr. Neurosci..

[91]  L. C. Hoffmann,et al.  Cerebellar theta oscillations are synchronized during hippocampal theta-contingent trace conditioning , 2009, Proceedings of the National Academy of Sciences.

[92]  Janet Wiles,et al.  Computational Influence of Adult Neurogenesis on Memory Encoding , 2009, Neuron.

[93]  Larry R Squire,et al.  Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. , 2009, Learning & memory.

[94]  D. Steindler,et al.  Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans. , 2010, Brain : a journal of neurology.

[95]  F. Gage,et al.  Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons , 2010, Proceedings of the National Academy of Sciences.

[96]  T. Curran,et al.  Functional role of gamma and theta oscillations in episodic memory , 2010, Neuroscience & Biobehavioral Reviews.

[97]  M. Penttonen,et al.  Hippocampo–cerebellar theta band phase synchrony in rabbits , 2010, Neuroscience.

[98]  Gerd Kempermann,et al.  Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years , 2010, PloS one.

[99]  K. Inokuchi,et al.  LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in the adult rat dentate gyrus , 2010, Molecular Brain.

[100]  S. Trouche,et al.  Young hippocampal neurons are critical for recent and remote spatial memory in adult mice , 2010, Neuroscience.

[101]  H. Eichenbaum,et al.  The Episodic Memory System: Neurocircuitry and Disorders , 2010, Neuropsychopharmacology.

[102]  Fernando Nottebohm,et al.  The origins of vocal learning: New sounds, new circuits, new cells , 2010, Brain and Language.

[103]  B L McNaughton,et al.  Hippocampal granule cells opt for early retirement , 2010, Hippocampus.

[104]  M. Drew,et al.  Arrest of adult hippocampal neurogenesis in mice impairs single- but not multiple-trial contextual fear conditioning. , 2010, Behavioral neuroscience.

[105]  Daniel M. Curlik,et al.  Associative learning increases adult neurogenesis during a critical period , 2011, The European journal of neuroscience.

[106]  T. Shors,et al.  Changing the rate and hippocampal dependence of trace eyeblink conditioning: Slow learning enhances survival of new neurons , 2011, Neurobiology of Learning and Memory.

[107]  Daniel M. Curlik,et al.  Learning Increases the Survival of Newborn Neurons Provided That Learning Is Difficult to Achieve and Successful , 2011, Journal of Cognitive Neuroscience.

[108]  L. Galea,et al.  Strain differences in neurogenesis and activation of new neurons in the dentate gyrus in response to spatial learning , 2011, Neuroscience.

[109]  J. Ding,et al.  Fibroblast growth factor-2 counteracts the effect of ciliary neurotrophic factor on spontaneous differentiation in adult hippocampal progenitor cells , 2012, Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.

[110]  R. Hen,et al.  Effects of adult‐generated granule cells on coordinated network activity in the dentate gyrus , 2012, Hippocampus.

[111]  S. Tronel,et al.  Adult‐born neurons are necessary for extended contextual discrimination , 2012, Hippocampus.

[112]  Joshua A. Gordon,et al.  Theta Oscillations in the Medial Prefrontal Cortex Are Modulated by Spatial Working Memory and Synchronize with the Hippocampus through Its Ventral Subregion , 2013, The Journal of Neuroscience.