The risk of myocardial infarction in rheumatoid arthritis and diabetes mellitus : a Danish nationwide cohort study

Ann Rheum Dis 2011;70:929–934. doi:10.1136/ard.2010.143396 929 Accepted 23 January 2011 Published Online First 9 March 2011 ABSTRACT Objectives To examine in a nationwide cohort whether the risk of myocardial infarction (MI) in patients with rheumatoid arthritis (RA) is comparable to the risk in patients with diabetes mellitus (DM). Methods The study included the entire Danish population followed from 1 January 1997 until 31 December 2006. Through individual level-linkage of nationwide administrative registers, the authors identifi ed subjects who developed RA and DM. The risk of MI was analysed using multivariable Poisson regression models including data on cardioprotective drugs, comorbidity and socioeconomic status. Results From a total of 4 311 022 individuals included in the cohort, 10 477 and 130 215 individuals developed RA and DM respectively. The overall incidence rate ratio (IRR) of MI in RA was 1.7 (95% CI 1.5 to 1.9), which was similar to the risk in DM (1.7 (1.6 to 1.8); p=0.64 for difference). The risk was signifi cantly increased in all groups when stratifying on age and gender, with higher RRs in younger patients. This was especially pronounced in women <50 years with RA or DM, who were subject to a sixfold increase in RR. The RA-related risk of MI was unaffected by the duration of pharmacological RA treatment and corresponded to the overall risk of MI observed in non-RA subjects, who were on the average 10 years older. Conclusions RA is associated with the same risk of MI as DM, and the risk of MI in RA patients generally corresponded to the risk in non-RA subjects 10 years older.

[1]  L. Skov,et al.  Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study , 2011, Journal of Internal Medicine.

[2]  Pierre-Antoine Gourraud,et al.  Traditional cardiovascular risk factors in rheumatoid arthritis: a meta-analysis. , 2011, Joint, bone, spine : revue du rhumatisme.

[3]  L. Alfredsson,et al.  Rapid increase in myocardial infarction risk following diagnosis of rheumatoid arthritis amongst patients diagnosed between 1995 and 2006 , 2010, Journal of internal medicine.

[4]  A. Vaag,et al.  Changes in short- and long-term cardiovascular risk of incident diabetes and incident myocardial infarction—a nationwide study , 2010, Diabetologia.

[5]  M. Hochberg,et al.  Explaining the cardiovascular risk associated with rheumatoid arthritis: traditional risk factors versus markers of rheumatoid arthritis severity , 2010, Annals of the rheumatic diseases.

[6]  L. Trinquart,et al.  High risk of clinical cardiovascular events in rheumatoid arthritis: Levels of associations of myocardial infarction and stroke through a systematic review and meta-analysis. , 2010, Archives of cardiovascular diseases.

[7]  D. Symmons,et al.  Dyslipidaemia in rheumatoid arthritis: the role of inflammation, drugs, lifestyle and genetic factors. , 2009, Current vascular pharmacology.

[8]  B. Dijkmans,et al.  Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study. , 2009, Arthritis and rheumatism.

[9]  G. Kitas,et al.  Atherosclerosis in Rheumatoid Arthritis Versus Diabetes: A Comparative Study , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[10]  D. Symmons,et al.  EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis , 2009, Annals of the rheumatic diseases.

[11]  Mohsen Sadatsafavi,et al.  Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies. , 2008, Arthritis and rheumatism.

[12]  H. John,et al.  Hypertension in rheumatoid arthritis. , 2008, Rheumatology.

[13]  F. Wolfe,et al.  The risk of myocardial infarction and pharmacologic and nonpharmacologic myocardial infarction predictors in rheumatoid arthritis: a cohort and nested case-control analysis. , 2008, Arthritis and rheumatism.

[14]  B. Dijkmans,et al.  Rheumatoid arthritis versus diabetes as a risk factor for cardiovascular disease: a cross-sectional study, the CARRÉ Investigation , 2008, Annals of the rheumatic diseases.

[15]  T. Therneau,et al.  High ten-year risk of cardiovascular disease in newly diagnosed rheumatoid arthritis patients: a population-based cohort study. , 2008, Arthritis and rheumatism.

[16]  A. Vaag,et al.  Diabetes Patients Requiring Glucose-Lowering Therapy and Nondiabetics With a Prior Myocardial Infarction Carry the Same Cardiovascular Risk: A Population Study of 3.3 Million People , 2008, Circulation.

[17]  S. Pocock,et al.  Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies , 2007, BMJ : British Medical Journal.

[18]  S. Gabriel,et al.  Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients? , 2007, Annals of the rheumatic diseases.

[19]  T. Therneau,et al.  Glucocorticoids and cardiovascular events in rheumatoid arthritis: a population-based cohort study. , 2007, Arthritis and rheumatism.

[20]  J. Avorn,et al.  Immunosuppressive medications and hospitalization for cardiovascular events in patients with rheumatoid arthritis. , 2006, Arthritis and rheumatism.

[21]  M. Hudson,et al.  Antirheumatic drug use and the risk of acute myocardial infarction. , 2006, Arthritis and rheumatism.

[22]  J. Tu,et al.  Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study , 2006, The Lancet.

[23]  J. Avorn,et al.  Patterns of cardiovascular risk in rheumatoid arthritis , 2006, Annals of the rheumatic diseases.

[24]  J W R Twisk,et al.  Lipids and inflammation: serial measurements of the lipid profile of blood donors who later developed rheumatoid arthritis , 2006, Annals of the rheumatic diseases.

[25]  Jan van der Meulen,et al.  Charlson scores based on ICD-10 administrative data were valid in assessing comorbidity in patients undergoing urological cancer surgery. , 2006, Journal of clinical epidemiology.

[26]  Jasvinder A Singh,et al.  Accuracy of Veterans Administration databases for a diagnosis of rheumatoid arthritis. , 2004, Arthritis and rheumatism.

[27]  E. Rimm,et al.  Cardiovascular risk factors in women with and without rheumatoid arthritis. , 2004, Arthritis and rheumatism.

[28]  A. Silman,et al.  Traditional cardiovascular risk factors measured prior to the onset of inflammatory polyarthritis. , 2004, Rheumatology.

[29]  C. Turesson,et al.  Increased incidence of cardiovascular disease in patients with rheumatoid arthritis: results from a community based study , 2004, Annals of the rheumatic diseases.

[30]  M. Osler,et al.  The validity of the diagnosis of acute myocardial infarction in routine statistics: a comparison of mortality and hospital discharge data with the Danish MONICA registry. , 2003, Journal of clinical epidemiology.

[31]  G L Freeman,et al.  High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors. , 2001, Arthritis and rheumatism.

[32]  M. Laakso,et al.  Epidemiology of risk factors for cardiovascular disease in diabetes and impaired glucose tolerance. , 1997, Atherosclerosis.

[33]  M. Liang,et al.  The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. , 1988, Arthritis and rheumatism.

[34]  M. Picco Risk of Arterial Thrombotic Events in Inflammatory Bowel Disease , 2009 .

[35]  C. Mackenzie,et al.  A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. , 1987, Journal of chronic diseases.