Adverse health effects of non-medical cannabis use

For over two decades, cannabis, commonly known as marijuana, has been the most widely used illicit drug by young people in high-income countries, and has recently become popular on a global scale. Epidemiological research during the past 10 years suggests that regular use of cannabis during adolescence and into adulthood can have adverse effects. Epidemiological, clinical, and laboratory studies have established an association between cannabis use and adverse outcomes. We focus on adverse health effects of greatest potential public health interest-that is, those that are most likely to occur and to affect a large number of cannabis users. The most probable adverse effects include a dependence syndrome, increased risk of motor vehicle crashes, impaired respiratory function, cardiovascular disease, and adverse effects of regular use on adolescent psychosocial development and mental health.

[1]  H. Morgenstern,et al.  Epidemiologic review of marijuana use and cancer risk. , 2005, Alcohol.

[2]  M. Yücel,et al.  Regional brain abnormalities associated with long-term heavy cannabis use. , 2008, Archives of general psychiatry.

[3]  D. Tashkin Smoked marijuana as a cause of lung injury. , 2005, Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace.

[4]  B Ludes,et al.  Comparison of the prevalence of alcohol, cannabis and other drugs between 900 injured drivers and 900 control subjects: results of a French collaborative study. , 2003, Forensic science international.

[5]  H. de Wit,et al.  Comparison of the subjective effects of Δ9-tetrahydrocannabinol and marijuana in humans , 2002, Psychopharmacology.

[6]  R. Murray,et al.  Changing incidence of psychotic disorders among the young in Zurich , 2007, Schizophrenia Research.

[7]  K I Bolla,et al.  Dose-related neurocognitive effects of marijuana use , 2002, Neurology.

[8]  E. Gardner Cannabinoid Interaction with Brain Reward Systems , 1999 .

[9]  Jerald G. Bachman,et al.  Smoking, Drinking, and Drug Use in Young Adulthood: The Impacts of New Freedoms and New Responsibilities , 1997 .

[10]  N. Martin,et al.  Escalation of drug use in early-onset cannabis users vs co-twin controls. , 2003, JAMA.

[11]  J. Ramaekers,et al.  Dose related risk of motor vehicle crashes after cannabis use. , 2004, Drug and alcohol dependence.

[12]  Reese T. Jones Cardiovascular System Effects of Marijuana , 2002, Journal of clinical pharmacology.

[13]  A. Lichtman,et al.  Cannabinoid tolerance and dependence. , 2005, Handbook of experimental pharmacology.

[14]  R. Gable Comparison of acute lethal toxicity of commonly abused psychoactive substances. , 2004, Addiction.

[15]  H. de Wit,et al.  Comparison of the subjective effects of Delta(9)-tetrahydrocannabinol and marijuana in humans. , 2002, Psychopharmacology.

[16]  W. Hall,et al.  Is cannabis a gateway drug? Testing hypotheses about the relationship between cannabis use and the use of other illicit drugs. , 2005, Drug and alcohol review.

[17]  J. Hughes,et al.  The cannabis withdrawal syndrome , 2006, Current opinion in psychiatry.

[18]  E. Abel Marihuana, the First Twelve Thousand Years , 1980 .

[19]  T. M. Pinkert Current research on the consequences of maternal drug abuse. , 1985, NIDA research monograph.

[20]  N. Solowij Cannabis and Cognitive Functioning , 1998 .

[21]  L. Degenhardt,et al.  Prevalence and correlates of cannabis use in developed and developing countries , 2007, Current opinion in psychiatry.

[22]  J. Manzanares,et al.  Pharmacological and biochemical interactions between opioids and cannabinoids. , 1999, Trends in pharmacological sciences.

[23]  B. Zuckerman,et al.  Marijuana: prenatal and postnatal exposure in the human. , 1985, NIDA research monograph.

[24]  Richie Poulton,et al.  Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study , 2002, BMJ : British Medical Journal.

[25]  Glyn Lewis,et al.  Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: historical cohort study , 2002, BMJ : British Medical Journal.

[26]  D. Fergusson,et al.  Cannabis dependence and psychotic symptoms in young people , 2003, Psychological Medicine.

[27]  R. Stephens,et al.  Cannabis Dependence: Its Nature, Consequences and Treatment , 2010 .

[28]  K. Straif,et al.  Cannabis Smoking and Risk of Lung Cancer in Men: A Pooled Analysis of Three Studies in Maghreb , 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[29]  Katrin Baumgartner,et al.  World Drug Report 2000 , 2000 .

[30]  Stephen Begg,et al.  Burden of disease and injury , , 2022 .

[31]  M. Weatherall,et al.  Effects of cannabis on pulmonary structure, function and symptoms , 2007, Thorax.

[32]  J. Concato,et al.  Effects of marijuana smoking on pulmonary function and respiratory complications: a systematic review. , 2007, Archives of internal medicine.

[33]  R. Bell,et al.  Does Early Drug Use Increase the Risk of Dropping out of High School? , 1998 .

[34]  L. Gottschalk,et al.  Effect of marijuana and placebo-marijuana smoking on psychological state and on psychophysiological cardiovascular functioning in anginal patients. , 1977, Biological psychiatry.

[35]  H. Morgenstern,et al.  Marijuana use and increased risk of squamous cell carcinoma of the head and neck. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[36]  Jean-Louis Martin,et al.  Cannabis intoxication and fatal road crashes in France: population based case-control study , 2005, BMJ : British Medical Journal.

[37]  J. Anthony Cannabis Dependence: The Epidemiology of Cannabis Dependence , 2006 .

[38]  E. Chronicle,et al.  Functional Imaging Studies in Cannabis Users , 2007, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[39]  R. Poulton,et al.  A longitudinal study of the effects of tobacco and cannabis exposure on lung function in young adults. , 2002, Addiction.

[40]  L J Horwood,et al.  Early onset cannabis use and psychosocial adjustment in young adults. , 1997, Addiction.

[41]  Rebecca M. Maertens,et al.  A comparison of mainstream and sidestream marijuana and tobacco cigarette smoke produced under two machine smoking conditions. , 2008, Chemical research in toxicology.

[42]  J. Muller,et al.  Triggering Myocardial Infarction by Marijuana , 2001, Circulation.

[43]  G. Richardson,et al.  Effects of prenatal marijuana exposure on child behavior problems at age 10. , 2000, Neurotoxicology and teratology.

[44]  W. Hall,et al.  Back-projection estimates of the number of dependent heroin users in Australia. , 2001, Addiction.

[45]  D. Fergusson,et al.  The developmental antecedents of illicit drug use: evidence from a 25-year longitudinal study. , 2008, Drug and alcohol dependence.

[46]  J. Tsao,et al.  The science of marijuana, 2nd Edition, Leslie Iversen. Oxford University Press, Oxford and New York (2008), ISBN-13: 978-0-19-532824-0, 273 pages, $29.95 , 2009 .

[47]  J. Os,et al.  Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people , 2004, BMJ : British Medical Journal.

[48]  M. Behnke,et al.  Early development of infants exposed to drugs prenatally. , 1999, Clinics in perinatology.

[49]  A. Smiley,et al.  Developing limits for driving under cannabis. , 2007, Addiction.

[50]  J. Muller,et al.  An exploratory prospective study of marijuana use and mortality following acute myocardial infarction. , 2008, American heart journal.

[51]  Ronald C. Kessler,et al.  Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: Basic findings from the National Comorbidity Survey. , 1994 .

[52]  D. Yurgelun-Todd,et al.  Neuropsychological performance in long-term cannabis users. , 2001, Archives of general psychiatry.

[53]  H.W.J. Robbe,et al.  influence of marijuana on driving , 1994 .

[54]  W. Swift,et al.  Cannabis potency and contamination: a review of the literature. , 2008, Addiction.

[55]  R. de Graaf,et al.  Cannabis use and psychosis: a longitudinal population-based study. , 2002, American journal of epidemiology.

[56]  A. Wodak Cannabis and health hazards , 1984 .

[57]  J. Hewitt,et al.  Relationship between Adolescent Marijuana Use and Young Adult Illicit Drug Use , 2006, Behavior genetics.

[58]  J B Carlin,et al.  Adolescent suicidal behaviours: a population-based study of risk , 1997, Psychological Medicine.

[59]  Robin M. Murray,et al.  Cannabis, the mind and society: the hash realities , 2007, Nature Reviews Neuroscience.

[60]  H. Kalant,et al.  The Health Effects of Cannabis , 1999 .

[61]  H. Morgenstern,et al.  Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study , 2006, Cancer Epidemiology Biomarkers & Prevention.

[62]  D. McCaffrey,et al.  Reassessing the marijuana gateway effect. , 2002, Addiction.

[63]  R. Mehra,et al.  The association between marijuana smoking and lung cancer: a systematic review. , 2006, Archives of internal medicine.

[64]  Alan D. Lopez,et al.  The burden of disease and injury in Australia. , 2001, Bulletin of the World Health Organization.

[65]  Raymond C. Peck,et al.  Influence of Marijuana on Driving , 1995 .

[66]  D. Kandel Stages and Pathways of Drug Involvement: Examining The Gateway Hypothesis , 2002 .

[67]  Peter B. Jones,et al.  Cannabis and schizophrenia: model projections of the impact of the rise in cannabis use on historical and future trends in schizophrenia in England and Wales. , 2007, Addiction.

[68]  H. Bauchner,et al.  Effects of maternal marijuana and cocaine use on fetal growth. , 1989, The New England journal of medicine.

[69]  Andra M. Smith,et al.  A literature review of the consequences of prenatal marihuana exposure. An emerging theme of a deficiency in aspects of executive function. , 2001, Neurotoxicology and teratology.

[70]  M. Kleiman Cannabis use and dependence: Public health and public policy , 2005 .

[71]  W. Hall,et al.  Testing hypotheses about the relationship between cannabis use and psychosis. , 2003, Drug and alcohol dependence.

[72]  W. Hall,et al.  The effects of adolescent cannabis use on educational attainment: a review. , 2000, Addiction.

[73]  Peter B. Jones,et al.  Cannabis use and risk of psychotic or aff ective mental health outcomes: a systematic review , 2007 .

[74]  J. Anthony,et al.  Into the world of illegal drug use: exposure opportunity and other mechanisms linking the use of alcohol, tobacco, marijuana, and cocaine. , 2002, American journal of epidemiology.

[75]  P. Swann,et al.  The involvement of drugs in drivers of motor vehicles killed in Australian road traffic crashes. , 2004, Accident; analysis and prevention.

[76]  D. Fergusson,et al.  Maternal use of cannabis and pregnancy outcome , 2002, BJOG : an international journal of obstetrics and gynaecology.

[77]  Alex Copello,et al.  Psychological and social sequelae of cannabis and other illicit drug use by young people: a systematic review of longitudinal, general population studies , 2004, The Lancet.

[78]  Alison M. Smiley,et al.  Marijuana: On-road and driving simulator studies , 1986 .

[79]  D. English,et al.  Maternal cannabis use and birth weight: a meta-analysis. , 1997, Addiction.

[80]  E. Mulder,et al.  Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring , 2006, Neuroscience & Biobehavioral Reviews.

[81]  J. Quickfall,et al.  Brain neuroimaging in cannabis use: a review. , 2006, The Journal of neuropsychiatry and clinical neurosciences.

[82]  Daniel S. O'Leary,et al.  Cerebellar hypoactivity in frequent marijuana users , 2000, Neuroreport.

[83]  A. Caspi,et al.  Trends in cannabis use prior to first presentation with schizophrenia, in South-East London between 1965 and 1999 , 2006, Psychological Medicine.

[84]  S. Sidney Cardiovascular Consequences of Marijuana Use , 2002, Journal of clinical pharmacology.

[85]  M. Roth,et al.  Respiratory and Immunologic Consequences of Marijuana Smoking , 2002, Journal of clinical pharmacology.

[86]  Peter B. Jones,et al.  Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review , 2007, The Lancet.

[87]  A. Beautrais,et al.  Cannabis abuse and serious suicide attempts. , 1999, Addiction.

[88]  Stephan Arndt,et al.  Effects of frequent marijuana use on memory-related regional cerebral blood flow , 2002, Pharmacology Biochemistry and Behavior.

[89]  Susan Goodwin Gerberich,et al.  Marijuana use and injury events resulting in hospitalization. , 2003, Annals of epidemiology.

[90]  D. Fergusson,et al.  Cannabis use and later life outcomes. , 2008, Addiction.

[91]  Sven Andréasson,et al.  CANNABIS AND SCHIZOPHRENIA A Longitudinal Study of Swedish Conscripts , 1987, The Lancet.

[92]  Thomas Babor,et al.  Cognitive functioning of long-term heavy cannabis users seeking treatment. , 2002, JAMA.

[93]  D. Stoffer,et al.  Effect of prenatal marijuana exposure on the cognitive development of offspring at age three. , 1994, Neurotoxicology and teratology.

[94]  G. Friedman,et al.  Marijuana use and cancer incidence (California, United States) , 1997, Cancer Causes & Control.

[95]  D. Fergusson,et al.  Cannabis use and other illicit drug use: testing the cannabis gateway hypothesis. , 2006, Addiction.

[96]  R. D. Merz,et al.  Risk of Selected Birth Defects with Prenatal Illicit Drug Use, Hawaii, 1986–2002 , 2006, Journal of toxicology and environmental health. Part A.

[97]  D. Kavanagh,et al.  Being stoned: a review of self-reported cannabis effects. , 2003, Drug and alcohol review.