The clinical uses of leptin.

[1]  J. Chan,et al.  The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. , 2003, The Journal of clinical investigation.

[2]  C. Mantzoros,et al.  Human Immunodeficiency Virus/Highly Active Antiretroviral Therapy-Associated Metabolic Syndrome: Clinical Presentation, Pathophysiology, and Therapeutic Strategies , 2003 .

[3]  Alexander S. Banks,et al.  STAT3 signalling is required for leptin regulation of energy balance but not reproduction , 2003, Nature.

[4]  H. Boeing,et al.  Adiponectin and protection against type 2 diabetes mellitus , 2003, The Lancet.

[5]  R. Lechler,et al.  Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. , 2003, The Journal of clinical investigation.

[6]  L. Orci,et al.  Lipoapoptosis: its mechanism and its diseases. , 2002, Biochimica et biophysica acta.

[7]  C. Kahn,et al.  Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. , 2002, Genes & development.

[8]  A. Garg,et al.  Lipodystrophy in Human Immunodeficiency Virus-Infected Patients , 2002 .

[9]  Graham M Lord,et al.  Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. , 2002, The Journal of clinical investigation.

[10]  R. Leibel.  The role of leptin in the control of body weight. , 2002, Nutrition reviews.

[11]  J. Friedman,et al.  The function of leptin in nutrition, weight, and physiology. , 2002, Nutrition reviews.

[12]  M. Reitman,et al.  Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy. , 2002, Diabetes.

[13]  N. Socci,et al.  Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss , 2002, Science.

[14]  Jonathan Krakoff,et al.  Adiponectin and development of type 2 diabetes in the Pima Indian population , 2002, The Lancet.

[15]  G. Shulman,et al.  Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity. , 2002, Diabetes.

[16]  P. Gorden,et al.  Effect of leptin replacement on pituitary hormone regulation in patients with severe lipodystrophy. , 2002, The Journal of clinical endocrinology and metabolism.

[17]  K. Petersen,et al.  Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. , 2002, The Journal of clinical investigation.

[18]  S. Heymsfield,et al.  Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. , 2002, The Journal of clinical endocrinology and metabolism.

[19]  M. Reitman,et al.  Leptin-replacement therapy for lipodystrophy. , 2002, The New England journal of medicine.

[20]  Young-Bum Kim,et al.  Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase , 2002, Nature.

[21]  J. Friedman,et al.  Selective deletion of leptin receptor in neurons leads to obesity. , 2001, The Journal of clinical investigation.

[22]  A. Itai,et al.  Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. , 2001, The Journal of clinical investigation.

[23]  Y. Terauchi,et al.  The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity , 2001, Nature Medicine.

[24]  M. Reitman,et al.  Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. , 2001, Diabetes.

[25]  Oksana Gavrilova,et al.  Hormones: Leptin and diabetes in lipoatrophic mice , 2000, Nature.

[26]  L. Leon,et al.  Torpor in mice is induced by both leptin-dependent and -independent mechanisms. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[27]  K. Fujioka,et al.  Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. , 1999, JAMA.

[28]  J. Flier,et al.  The Role of SOCS-3 in Leptin Signaling and Leptin Resistance* , 1999, The Journal of Biological Chemistry.

[29]  A. Prentice,et al.  Effects of recombinant leptin therapy in a child with congenital leptin deficiency. , 1999, The New England journal of medicine.

[30]  R. Hammer,et al.  Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy , 1999, Nature.

[31]  J. Friedman,et al.  Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice. , 1999, Diabetes.

[32]  R. Hammer,et al.  Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. , 1998, Genes & development.

[33]  M. Olive,et al.  Life without white fat: a transgenic mouse. , 1998, Genes & development.

[34]  A. Strosberg,et al.  A leptin missense mutation associated with hypogonadism and morbid obesity , 1998, Nature Genetics.

[35]  J. Flier,et al.  Identification of SOCS-3 as a potential mediator of central leptin resistance. , 1998, Molecular cell.

[36]  R. Burcelin,et al.  Acute stimulation of glucose metabolism in mice by leptin treatment , 1997, Nature.

[37]  S. O’Rahilly,et al.  Congenital leptin deficiency is associated with severe early-onset obesity in humans , 1997, Nature.

[38]  J. Flier,et al.  Leptin accelerates the onset of puberty in normal female mice. , 1997, The Journal of clinical investigation.

[39]  K. Mounzih,et al.  Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin , 1997, Science.

[40]  C. Mantzoros,et al.  Role of leptin in the neuroendocrine response to fasting , 1996, Nature.

[41]  F. Chehab,et al.  Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin , 1996, Nature Genetics.

[42]  M. Pelleymounter,et al.  Effects of the obese gene product on body weight regulation in ob/ob mice. , 1995, Science.

[43]  R. Devos,et al.  Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. , 1995, Science.

[44]  Steven L. Cohen,et al.  Weight-reducing effects of the plasma protein encoded by the obese gene. , 1995, Science.

[45]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1994, Nature.

[46]  A. Garg,et al.  Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy. , 2003, Diabetes care.