Mesocorticolimbic hyperactivity of deprived smokers and brain imaging

We determined the association of neuronal circuitry with the desire to smoke by acquiring and analyzing functional MRI data. The data were acquired in both abstained and subsequently satiated (by ‘natural’ cigarette smoking) heavy smokers and also in demographically and intellectually matched nonsmokers. During the acquisition, participants were viewing alternating smoking and nonsmoking images that were interleaved by fixation images. From the results, the activities in the mesocorticolimbic pathway including the orbitofrontal cortex, parahippocampus, hippocampus, and midbrain were significantly negatively correlated with carbon monoxide (CO) levels. In contrast, the activities in the motor area and the posterior cingulate cortex plus precuneus were significantly positively correlated with the CO levels. This is the first study to show that mesocorticolimbic and midbrain activities are strongly associated with CO levels, and therefore, possibly with smoking desire levels because of the strong correlation between CO levels and blood nicotine levels.

[1]  S J Heishman,et al.  Effect of nicotine on brain activation during performance of a working memory task , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[2]  W. Lee,et al.  Experience-Dependent Plasticity of Cerebellar Vermis in Basketball Players , 2009, The Cerebellum.

[3]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[4]  Jong-Hwan Lee,et al.  Real-time fMRI-based neurofeedback reinforces causality of attention networks , 2012, Neuroscience Research.

[5]  M. Raw,et al.  Improving smoking cessation approaches at the individual level , 2012, Tobacco Control.

[6]  D. Hommer,et al.  Imaging brain response to reward in addictive disorders , 2011, Annals of the New York Academy of Sciences.

[7]  Rachel Kozink,et al.  Individual Differences in Nicotine Dependence, Withdrawal Symptoms, and Sex Predict Transient fMRI-BOLD Responses to Smoking Cues , 2008, Neuropsychopharmacology.

[8]  R. Narendran,et al.  Imaging neurotransmitter release by drugs of abuse. , 2010, Current topics in behavioral neurosciences.

[9]  Karl J. Friston,et al.  Analysis of fMRI Time-Series Revisited , 1995, NeuroImage.

[10]  L. Kozlowski,et al.  The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. , 1991, British journal of addiction.

[11]  Heidi Johansen-Berg,et al.  Ventral Striatum/Nucleus Accumbens Activation to Smoking-Related Pictorial Cues in Smokers and Nonsmokers: A Functional Magnetic Resonance Imaging Study , 2005, Biological Psychiatry.

[12]  Timothy Edward John Behrens,et al.  New approaches for exploring anatomical and functional connectivity in the human brain , 2004, Biological Psychiatry.

[13]  E. Stein,et al.  Chronic smoking, but not acute nicotine administration, modulates neural correlates of working memory , 2010, Psychopharmacology.

[14]  Kevin A. Johnson,et al.  Volitional reduction of anterior cingulate cortex activity produces decreased cue craving in smoking cessation: a preliminary real‐time fMRI study , 2013, Addiction biology.

[15]  S. Whitfield-Gabrieli,et al.  Brain hypoactivation, autonomic nervous system dysregulation, and gonadal hormones in depression: A preliminary study , 2012, Neuroscience Letters.

[16]  M. Kaufman,et al.  Prefrontal and limbic resting state brain network functional connectivity differs between nicotine-dependent smokers and non-smoking controls. , 2012, Drug and alcohol dependence.

[17]  M. Jarvik,et al.  Nicotine Blood Levels and Subjective Craving for Cigarettes , 2000, Pharmacology Biochemistry and Behavior.

[18]  J. Monterosso,et al.  Ventral Striatal Dopamine Release in Response to Smoking a Regular vs a Denicotinized Cigarette , 2009, Neuropsychopharmacology.

[19]  Adrian H. Taylor,et al.  Acute exercise modulates cigarette cravings and brain activation in response to smoking-related images: an fMRI study , 2009, Psychopharmacology.

[20]  Karl J. Friston,et al.  Analysis of fMRI Time-Series Revisited—Again , 1995, NeuroImage.

[21]  Johan N Lundström,et al.  Identification of human gustatory cortex by activation likelihood estimation , 2011, Human brain mapping.

[22]  E. Stein,et al.  Chronic Exposure to Nicotine Is Associated with Reduced Reward-Related Activity in the Striatum but not the Midbrain , 2012, Biological Psychiatry.

[23]  N. Volkow,et al.  Imaging dopamine's role in drug abuse and addiction , 2009, Neuropharmacology.

[24]  D. Rubin,et al.  Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging. , 2002, The American journal of psychiatry.

[25]  R. See,et al.  The neurocircuitry of addiction: an overview , 2008, British journal of pharmacology.