论文信息 - The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

The Mannich reaction of hydrazones: improved reactivity under solvent-free conditions

The Mannich reaction of hydrazones can be performed without solvent by simply mixing the hydrazone with two to three equivalents of a secondary amine and formaldehyde. Best yields and conditions are obtained with p-nitro substituted arylhydrazones. These conditions allow the efficient coupling of simple hydrazones that failed to react in toluene or ethanol solutions.

L. Gautier | L. Harwood | L. Grimaud | L. E. Kaim | V. Michaut

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