Likelihood-based inference with singular information matrix

1Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston MA 02115, USA. *E-mail: andrea@hsph.harvard.edu 2Nuffield College, Oxford OX1 1NF, UK 3Centro Nazionale Universitario di Calcolo Elettronico, Consiglio Nazionale delle Ricerche, Via Santa Maria 36, I-56126 Pisa, Italy 4Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston MA 02115, USA

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