Soy protein isoflavones, lipids and arterial disease

There is convincing evidence that soybean products have beneficial effects on cardiovascular disease risk factors. Interest in understanding which components of the soybean are responsible for the potential benefits on cardiovascular disease risk factors and the magnitude of their effect continues. This review focuses on the scientific literature published during 1999-2001, evaluating the effects of soy protein isolate, soy foods, and purified isoflavones on plasma lipid concentrations and other cardiovascular disease outcomes.

[1]  A. Duncan,et al.  Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. , 2001, The American journal of clinical nutrition.

[2]  T. Sanders,et al.  The Phytoestrogen Genistein Produces Acute Nitric Oxide–Dependent Dilation of Human Forearm Vasculature With Similar Potency to 17&bgr;-Estradiol , 2001, Circulation.

[3]  C. Nagata,et al.  Hypocholesterolemic effect of soymilk supplementation with usual diet in premenopausal normolipidemic Japanese women. , 2000, Preventive medicine.

[4]  L. Howes,et al.  The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post menopausal women with mild to moderate hypercholesterolaemia. , 2000, Atherosclerosis.

[5]  T. Sanders,et al.  Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. , 2000, The American journal of clinical nutrition.

[6]  F. Ursini,et al.  Synergistic inhibition of LDL oxidation by phytoestrogens and ascorbic acid. , 2000, Free radical biology & medicine.

[7]  A. Duncan,et al.  Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. , 2000, The American journal of clinical nutrition.

[8]  J. Simons,et al.  Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. , 2000, The American journal of cardiology.

[9]  C. Hasler,et al.  Effects of feeding 4 levels of soy protein for 3 and 6 wk on blood lipids and apolipoproteins in moderately hypercholesterolemic men. , 2000, The American journal of clinical nutrition.

[10]  E. Diamandis,et al.  Effect of soy protein foods on low-density lipoprotein oxidation and ex vivo sex hormone receptor activity--a controlled crossover trial. , 2000, Metabolism: clinical and experimental.

[11]  E. Ashton,et al.  Effects of soy as tofu vs meat on lipoprotein concentrations , 2000, European Journal of Clinical Nutrition.

[12]  S. J. Smith,et al.  The effect of supplementation with isoflavones on plasma lipids and oxidisability of low density lipoprotein in premenopausal women. , 1999, Atherosclerosis.

[13]  J. Crouse,et al.  A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. , 1999, Archives of internal medicine.

[14]  C. Sirtori,et al.  Double-blind study of the addition of high-protein soya milk v. cows' milk to the diet of patients with severe hypercholesterolaemia and resistance to or intolerance of statins , 1999, British Journal of Nutrition.

[15]  Philip Lewis,et al.  Incorporation of esterified soybean isoflavones with antioxidant activity into low density lipoprotein. , 1999, Biochimica et biophysica acta.

[16]  A. Collins,et al.  Effects of a soy milk supplement on plasma cholesterol levels and oxidative DNA damage in men – a pilot study , 1999, European journal of nutrition.

[17]  W. Duane.  Effects of soybean protein and very low dietary cholesterol on serum lipids, biliary lipids, and fecal sterols in humans. , 1999, Metabolism: clinical and experimental.

[18]  P. Kris-Etherton,et al.  Effects of the National Cholesterol Education Program's Step I and Step II dietary intervention programs on cardiovascular disease risk factors: a meta-analysis. , 1999, The American journal of clinical nutrition.

[19]  J. Cameron,et al.  Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. , 1999, The Journal of clinical endocrinology and metabolism.

[20]  H. Meinertz,et al.  Lipoprotein(a) and dietary proteins: casein lowers lipoprotein(a) concentrations as compared with soy protein. , 1999, The American journal of clinical nutrition.

[21]  R. DuBroff,et al.  Soy Phytoestrogens Improve Endothelial Dysfunction in Postmenopausal Women: P-67. , 1999 .

[22]  G. Burke,et al.  Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. , 1999, Menopause.

[23]  S. Pilch.  Food labeling: health claims; soy protein and coronary heart disease. Food and Drug Administration, HHS. Final rule. , 1999, Federal register.

[24]  S. Potter,et al.  Soy protein and cardiovascular disease: the impact of bioactive components in soy. , 2009, Nutrition reviews.

[25]  M. Anthony,et al.  Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. , 1997, Fertility and sterility.

[26]  B V Howard,et al.  Dietary guidelines for healthy American adults. A statement for health professionals from the Nutrition Committee, American Heart Association. , 1996, Circulation.

[27]  James W. Anderson,et al.  Meta-analysis of the effects of soy protein intake on serum lipids. , 1995, The New England journal of medicine.

[28]  D Kromhout,et al.  Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study. , 1995, JAMA.

[29]  C. Sirtori,et al.  Soybean Protein Diet and Plasma Cholesterol: From Therapy to Molecular Mechanisms , 1993, Annals of the New York Academy of Sciences.

[30]  B. Henderson,et al.  Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. , 1991, British Journal of Cancer.

[31]  H. Adlercreutz.  Western diet and Western diseases: some hormonal and biochemical mechanisms and associations. , 1990, Scandinavian journal of clinical and laboratory investigation. Supplementum.

[32]  Dietary guidelines for healthy American adults. A statement for physicians and health professionals by the Nutrition Committee, American Heart Association. , 1986, Circulation.

[33]  L. Tavazzi,et al.  Clinical experience with the soybean protein diet in the treatment of hypercholesterolemia. , 1979, The American journal of clinical nutrition.

[34]  C. Sirtori,et al.  SOYBEAN-PROTEIN DIET IN THE TREATMENT OF TYPE-II HYPERLIPOPROTEINÆMIA , 1977, The Lancet.

[35]  J. E. Dunn.  Cancer epidemiology in populations of the United States--with emphasis on Hawaii and California--and Japan. , 1975, Cancer research.

[36]  T. Gordon.  Further mortality experience among Japanese Americans. , 1967, Public health reports.