Mesenchymal Stem Cells and Tooth Engineering

Tooth loss compromises human oral health. Although several prosthetic methods, such as artificial denture and dental implants, are clinical therapies to tooth loss problems, they are thought to have safety and usage time issues. Recently, tooth tissue engineering has attracted more and more attention. Stem cell based tissue engineering is thought to be a promising way to replace the missing tooth. Mesenchymal stem cells (MSCs) are multipotent stem cells which can differentiate into a variety of cell types. The potential MSCs for tooth regeneration mainly include stem cells from human exfoliated deciduous teeth (SHEDs), adult dental pulp stem cells (DPSCs), stem cells from the apical part of the papilla (SCAPs), stem cells from the dental follicle (DFSCs), periodontal ligament stem cells (PDLSCs) and bone marrow derived mesenchymal stem cells (BMSCs). This review outlines the recent progress in the mesenchymal stem cells used in tooth regeneration.

[1]  J. Gimble,et al.  Human adipose-derived adult stem cells produce osteoid in vivo. , 2004, Tissue engineering.

[2]  D. Ma,et al.  The biological effect of dentin noncollagenous proteins (DNCPs) on the human periodontal ligament stem cells (HPDLSCs) in vitro and in vivo. , 2008, Tissue engineering. Part A.

[3]  T. Diekwisch,et al.  Dental follicle progenitor cell heterogeneity in the developing mouse periodontium. , 2006, Stem cells and development.

[4]  H. Sagara,et al.  The sequential seeding of epithelial and mesenchymal cells for tissue-engineered tooth regeneration. , 2007, Biomaterials.

[5]  R. Class,et al.  Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[6]  O. Matsuo,et al.  Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into immunocompromised mice , 2007, Cell biology international.

[7]  L. Tang,et al.  Dentin non‐collagenous proteins (dNCPs) can stimulate dental follicle cells to differentiate into cementoblast lineages , 2008, Biology of the cell.

[8]  Takashi Takata,et al.  Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells. , 2004, Journal of periodontology.

[9]  O. Trubiani,et al.  Nitric oxide production during the osteogenic differentiation of human periodontal ligament mesenchymal stem cells. , 2009, Acta histochemica.

[10]  A. Sloan,et al.  Stem cells and the dental pulp: potential roles in dentine regeneration and repair. , 2007, Oral diseases.

[11]  J. Nör.  Tooth regeneration in operative dentistry. , 2006, Operative dentistry.

[12]  Sabine Kuchler-Bopp,et al.  Tissue engineering of tooth crown, root, and periodontium. , 2006, Tissue engineering.

[13]  S. Modino,et al.  Stem-cell-based Tissue Engineering of Murine Teeth , 2004, Journal of dental research.

[14]  Miho Ogawa,et al.  The development of a bioengineered organ germ method , 2007, Nature Methods.

[15]  N. Zini,et al.  Regenerative potential of human periodontal ligament derived stem cells on three-dimensional biomaterials: a morphological report. , 2008, Journal of biomedical materials research. Part A.

[16]  John A Jansen,et al.  The performance of human dental pulp stem cells on different three-dimensional scaffold materials. , 2006, Biomaterials.

[17]  M. Sefton,et al.  Tissue engineering. , 1998, Journal of cutaneous medicine and surgery.

[18]  S. Gronthos,et al.  Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Y. Duan,et al.  Apical tooth germ cell-conditioned medium enhances the differentiation of periodontal ligament stem cells into cementum/periodontal ligament-like tissues. , 2009, Journal of periodontal research.

[20]  S. Yao,et al.  Differentiation of Stem Cells in the Dental Follicle , 2008, Journal of dental research.

[21]  F. Carinci,et al.  Long‐term cryopreservation of dental pulp stem cells (SBP‐DPSCs) and their differentiated osteoblasts: A cell source for tissue repair , 2006, Journal of cellular physiology.

[22]  Wei Tang,et al.  Dentin Sialophosphoprotein-Promoted Mineralization and Expression of Odontogenic Genes in Adipose-Derived Stromal Cells , 2007, Cells Tissues Organs.

[23]  R. Rosenfeld.  Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[24]  Stan Gronthos,et al.  SHED: Stem cells from human exfoliated deciduous teeth , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[25]  M. Ueda,et al.  Collagen type I matrix affects molecular and cellular behavior of purified porcine dental follicle cells , 2008, Cell and Tissue Research.

[26]  Wei Tang,et al.  Odontogenic differentiation of adipose-derived stem cells for tooth regeneration: necessity, possibility, and strategy. , 2008, Medical hypotheses.

[27]  R. C. Garcez,et al.  Human periodontal ligament: a niche of neural crest stem cells. , 2008, Journal of periodontal research.

[28]  M. Ueda,et al.  Subcultured Odontogenic Epithelial Cells in Combination with Dental Mesenchymal Cells Produce Enamel–Dentin-Like Complex Structures , 2007, Cell transplantation.

[29]  P. Yelick,et al.  Bioengineered Teeth from Cultured Rat Tooth Bud Cells , 2004, Journal of dental research.

[30]  P. Yelick,et al.  Tissue Engineering of Complex Tooth Structures on Biodegradable Polymer Scaffolds , 2002, Journal of dental research.

[31]  Zhi-yong Li,et al.  Odontogenic potential of bone marrow mesenchymal stem cells. , 2007, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[32]  B. Lim,et al.  Identification of Common Pathways Mediating Differentiation of Bone Marrow‐ and Adipose Tissue‐Derived Human Mesenchymal Stem Cells into Three Mesenchymal Lineages , 2007, Stem cells.

[33]  S. Shi,et al.  Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth. , 2008, Journal of endodontics.

[34]  Y. Haikel,et al.  Bone Marrow Cells Can Give Rise to Ameloblast-like Cells , 2006, Journal of dental research.

[35]  C. Morsczeck,et al.  Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. , 2005, Matrix biology : journal of the International Society for Matrix Biology.

[36]  H. Luder,et al.  Stem cells for tooth engineering. , 2008, European cells & materials.

[37]  A. Boyde,et al.  Stem Cell Properties of Human Dental Pulp Stem Cells , 2002, Journal of dental research.

[38]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[39]  Min Zhu,et al.  Human adipose tissue is a source of multipotent stem cells. , 2002, Molecular biology of the cell.

[40]  S. Iseki,et al.  Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo , 2006, Cell and Tissue Research.

[41]  M. Ueda,et al.  A novel culture system for porcine odontogenic epithelial cells using a feeder layer. , 2006, Archives of oral biology.

[42]  H. Arzate,et al.  Human dental follicle cells acquire cementoblast features under stimulation by BMP-2/-7 and enamel matrix derivatives (EMD) in vitro , 2007, Cell and Tissue Research.

[43]  K. Kusumoto,et al.  Bone tissue engineering using human adipose-derived stem cells and honeycomb collagen scaffold. , 2008, Journal of biomedical materials research. Part A.

[44]  F. García-Godoy,et al.  Stem cell responses in tooth regeneration. , 2004, Stem cells and development.