Right ventricular regional function using MR tagging: Normals versus chronic pulmonary hypertension

Right ventricular (RV) regional function, in both normal and diseased states, is not well characterized. Using 1D MR myocardial tagging, RV and septal intramyocardial segmental shortening was noninvasively measured in ten healthy subjects and in seven patients with chronic pulmonary hypertension. The normal RV free wall regional shortening was not uniform. A pattern of increasing RV free wall short‐axis shortening was found from the RV outflow tract to the RV apex, and a more complex pattern of RV free wall long‐axis shortening was observed. Both regional short‐ and long‐axis shortening were globally reduced in pulmonary hypertension patients, with the greatest decreases in the RV outflow tract and in the basal septal wall region. Regional RV function can be quantitatively evaluated using MR tagging to determine the impact of chronic pulmonary hypertension on RV performance.

[1]  J ANZOLA,et al.  Right ventricular contraction. , 1956, The American journal of physiology.

[2]  R. Lower,et al.  Observations on the behavior of the right ventricular outflow tract, with reference to its developmental origins. , 1962, The American journal of medicine.

[3]  A. Beckett,et al.  AKUFO AND IBARAPA. , 1965, Lancet.

[4]  W. C. Randall,et al.  Interrelationship of architecture and function of the right ventricle. , 1970, The American journal of physiology.

[5]  W. C. Randall,et al.  Structural basis for cardiac function. , 1970, The American journal of physiology.

[6]  E. Sonnenblick,et al.  Cardiac ultrastructure and function: sarcomeres in the right ventricle. , 1971, The American journal of physiology.

[7]  T. Pexieder.  Development of the outflow tract of the embryonic heart. , 1978, Birth defects original article series.

[8]  D. Altman,et al.  STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT , 1986, The Lancet.

[9]  L. Waldman,et al.  Technique for Measuring Regional Two‐Dimensional Finite Strains in Canine Left Ventricle , 1988, Circulation research.

[10]  Stephen J. Riederer,et al.  Fast limited flip angle mr subtraction angiography , 1988, Magnetic resonance in medicine.

[11]  L. Axel,et al.  Heart wall motion: improved method of spatial modulation of magnetization for MR imaging. , 1989, Radiology.

[12]  L. Axel,et al.  MR imaging of motion with spatial modulation of magnetization. , 1989, Radiology.

[13]  L Axel,et al.  Circumferential Myocardial Shortening in the Normal Human Left Ventricle: Assessment by Magnetic Resonance Imaging Using Spatial Modulation of Magnetization , 1991, Circulation.

[14]  E. Zerhouni,et al.  Quantification of and Correction for Left Ventricular Systolic Long‐Axis Shortening by Magnetic Resonance Tissue Tagging and Slice Isolation , 1991, Circulation.

[15]  S. Moreland,et al.  Characterization of magnesium-induced contractions in detergent-skinned swine carotid media. , 1991, The American journal of physiology.

[16]  R. Edelman,et al.  Cineangiography of the heart in a single breath hold with a segmented turboFLASH sequence. , 1991, Radiology.

[17]  M. Marcus,et al.  Patterns of global and regional systolic and diastolic function in the normal right ventricle assessed by ultrafast computed tomography. , 1991, Journal of the American College of Cardiology.

[18]  Tuesday morning Columbus hall K papers 217–224. Cardiac imaging: Technical , 1991 .

[19]  J. Pauly,et al.  Parameter relations for the Shinnar-Le Roux selective excitation pulse design algorithm [NMR imaging]. , 1991, IEEE transactions on medical imaging.

[20]  Monday afternoon Columbus hall K papers 165–172. Cardiac imaging: Clinical , 1991 .

[21]  L Axel,et al.  Efficient method for selecting cardiac magnetic resonance image locations. , 1992, Investigative radiology.

[22]  T E Gillespie,et al.  Double injuries of the forearm: a common occurrence. , 1992, Radiology.

[23]  E. McVeigh,et al.  Cardiac Tagging with Breath‐Hold Cine MRI , 1992, Magnetic resonance in medicine.

[24]  P Boesiger,et al.  True myocardial motion tracking , 1994, Magnetic resonance in medicine.

[25]  D. Zipes,et al.  Efferent Sympathetic and Vagal Innervation of the Canine Right Ventricle , 1994, Circulation.

[26]  E. McVeigh,et al.  Tag contrast in breath‐hold CINE cardiac MRI , 1994, Magnetic resonance in medicine.

[27]  A. Young,et al.  Two‐dimensional Left Ventricular Deformation During Systole Using Magnetic Resonance Imaging With Spatial Modulation of Magnetization , 1994, Circulation.

[28]  A. Young,et al.  Three‐Dimensional Left Ventricular Deformation in Hypertrophic Cardiomyopathy , 1994, Circulation.

[30]  A. Crawley,et al.  Regional left ventricular systolic function in relation to the cavity geometry in patients with chronic right ventricular pressure overload. A three-dimensional tagged magnetic resonance imaging study. , 1995, Circulation.

[31]  L Axel,et al.  An improved quadrature or phased‐array coil for MR cardiac imaging , 1995, Magnetic resonance in medicine.

[32]  B. Brundage,et al.  Pressure and volume loading of the right ventricle have opposite effects on left ventricular ejection fraction. , 1995, Circulation.