Histidine kinases and response regulators in networks.

Two-component systems, composed of a histidine kinase (HK) and a response regulator (RR), are the major signal transduction devices in bacteria. Originally it was thought that these two components function as linear, phosphorylation-driven stimulus-response system. Here, we will review how accessory proteins are employed by HKs and RRs to mediate signal integration, scaffolding, interconnection and allosteric regulation, and how these two components are embedded in regulatory networks.

[1]  Samuel I. Miller,et al.  Antimicrobial Peptides Activate the Rcs Regulon through the Outer Membrane Lipoprotein RcsF , 2010, Journal of bacteriology.

[2]  J. Casadesús,et al.  Regulation of capsule synthesis and cell motility in Salmonella enterica by the essential gene igaA. , 2002, Genetics.

[3]  M. Simon,et al.  Histidine and aspartate phosphorylation: two-component systems and the limits of homology. , 1994, Trends in biochemical sciences.

[4]  Y. Eguchi,et al.  Regulation of Acid Resistance by Connectors of Two-Component Signal Transduction Systems in Escherichia coli , 2010, Journal of bacteriology.

[5]  R. Heermann,et al.  Stimulus Perception and Signaling in Histidine Kinases , 2009 .

[6]  Dongwoo Shin,et al.  A Positive Feedback Loop Promotes Transcription Surge That Jump-Starts Salmonella Virulence Circuit , 2006, Science.

[7]  T. Raivio,et al.  Three (and more) component regulatory systems – auxiliary regulators of bacterial histidine kinases , 2010, Molecular microbiology.

[8]  B. Bassler,et al.  Bacterial quorum-sensing network architectures. , 2009, Annual review of genetics.

[9]  M. Pettinari,et al.  Null mutations in the essential gene yrfF (mucM) are not lethal in rcsB, yojN or rcsC strains of Salmonella enterica serovar Typhimurium. , 2003, FEMS microbiology letters.

[10]  J. Herrou,et al.  A structural model of anti‐anti‐σ inhibition by a two‐component receiver domain: the PhyR stress response regulator , 2010, Molecular microbiology.

[11]  Dongwoo Shin,et al.  Signal-dependent Binding of the Response Regulators PhoP and PmrA to Their Target Promoters in Vivo* , 2005, Journal of Biological Chemistry.

[12]  J. Eubanks,et al.  Fate , 2010, Annals of Internal Medicine.

[13]  Davi R. Ortega,et al.  Universal architecture of bacterial chemoreceptor arrays , 2009, Proceedings of the National Academy of Sciences.

[14]  Kirsten Jung,et al.  AI-1 Influences the Kinase Activity but Not the Phosphatase Activity of LuxN of Vibrio harveyi* , 2006, Journal of Biological Chemistry.

[15]  J. S. Parkinson,et al.  Communication modules in bacterial signaling proteins. , 1992, Annual review of genetics.

[16]  Wendell A. Lim,et al.  Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information , 2011, Science.

[17]  R. Heermann,et al.  The universal stress protein UspC scaffolds the KdpD/KdpE signaling cascade of Escherichia coli under salt stress. , 2009, Journal of molecular biology.

[18]  X. Lai,et al.  The Integrity of the Periplasmic Domain of the VirA Sensor Kinase Is Critical for Optimal Coordination of the Virulence Signal Response in Agrobacterium tumefaciens , 2011, Journal of bacteriology.

[19]  Akinori Kato,et al.  Connecting two-component regulatory systems by a protein that protects a response regulator from dephosphorylation by its cognate sensor. , 2004, Genes & development.

[20]  Kirsten Jung,et al.  Heterogeneity in quorum sensing‐regulated bioluminescence of Vibrio harveyi , 2009, Molecular microbiology.

[21]  T. Mascher,et al.  Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases , 2006, Microbiology and Molecular Biology Reviews.

[22]  E. Groisman,et al.  A small protein that mediates the activation of a two‐component system by another two‐component system , 2000, The EMBO journal.

[23]  T. Mascher,et al.  Coevolution of ABC Transporters and Two-Component Regulatory Systems as Resistance Modules against Antimicrobial Peptides in Firmicutes Bacteria , 2011, Journal of bacteriology.

[24]  G. Boons,et al.  Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems , 2011 .

[25]  J. Kirby,et al.  Chemotaxis-like regulatory systems: unique roles in diverse bacteria. , 2009, Annual review of microbiology.

[26]  Oscar P. Kuipers,et al.  Heterochronic Phosphorelay Gene Expression as a Source of Heterogeneity in Bacillus subtilis Spore Formation , 2010, Journal of bacteriology.

[27]  Christopher A. Voigt,et al.  Kinetic buffering of cross talk between bacterial two-component sensors. , 2009, Journal of molecular biology.

[28]  S. Hunke,et al.  Misfolded maltose binding protein MalE219 induces the CpxRA envelope stress response by stimulating phosphoryl transfer from CpxA to CpxR. , 2009, Research in microbiology.

[29]  E. Groisman,et al.  A Signal Transduction System that Responds to Extracellular Iron , 2000, Cell.

[30]  T. Mizuno,et al.  His-Asp phosphotransfer signal transduction. , 1998, Journal of biochemistry.

[31]  G. L. Hazelbauer,et al.  Core unit of chemotaxis signaling complexes , 2011, Proceedings of the National Academy of Sciences.

[32]  K. Jung,et al.  The regulatory interplay between membrane‐integrated sensors and transport proteins in bacteria , 2009, Molecular microbiology.

[33]  Protein footprinting in a complex milieu: identifying the interaction surfaces of the chemotaxis adaptor protein CheW. , 2011, Journal of molecular biology.

[34]  E. Groisman,et al.  Mg2+ as an Extracellular Signal: Environmental Regulation of Salmonella Virulence , 1996, Cell.

[35]  J. Itou,et al.  Molecular Mechanism of Transcriptional Cascade Initiated by the EvgS/EvgA System in Escherichia coli K-12 , 2009, Bioscience, biotechnology, and biochemistry.

[36]  M. Inouye,et al.  Histidine kinases: diversity of domain organization , 1999, Molecular microbiology.

[37]  M. Laub,et al.  Allosteric Regulation of Histidine Kinases by Their Cognate Response Regulator Determines Cell Fate , 2008, Cell.

[38]  Roger Alexander,et al.  CheV: CheW-like coupling proteins at the core of the chemotaxis signaling network. , 2010, Trends in microbiology.

[39]  Emily S. Charlson,et al.  MzrA: a novel modulator of the EnvZ/OmpR two-component regulon , 2009, Molecular microbiology.

[40]  M. Simon,et al.  Structure of CheA, a Signal-Transducing Histidine Kinase , 1999, Cell.

[41]  N. Wingreen,et al.  A dynamic-signaling-team model for chemotaxis receptors in Escherichia coli , 2010, Proceedings of the National Academy of Sciences.

[42]  D. Sturdevant,et al.  The antimicrobial peptide‐sensing system aps of Staphylococcus aureus , 2007, Molecular microbiology.

[43]  J. Hoch,et al.  Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay , 1991, Cell.

[44]  S. Gottesman,et al.  Multiple pathways for regulation of σS (RpoS) stability in Escherichia coli via the action of multiple anti‐adaptors , 2008, Molecular microbiology.

[45]  Ned S Wingreen,et al.  Active regulation of receptor ratios controls integration of quorum-sensing signals in Vibrio harveyi , 2011, Molecular systems biology.

[46]  D. Clarke.  The Rcs phosphorelay: more than just a two-component pathway. , 2010, Future microbiology.

[47]  Edgardo Ugalde,et al.  Regulatory dynamics of standard two-component systems in bacteria. , 2010, Journal of theoretical biology.