The effect of changes in lung volume on the size and shape of alveoli

1. A technique is described by which living anaesthetized guinea‐pigs were artificially ventilated with a positive and negative pressure cycle, and rapidly frozen at the instant of cessation of ventilation at a preselected point on the respiratory cycle.

[1]  M. Thomson,et al.  The effect of age, body size and lung volume change on alveolar‐capillary permeability and diffusing capacity in man , 1959, The Journal of physiology.

[2]  H. W. Chalkley,et al.  A Method for Estimating Volume-Surface Ratios. , 1949, Science.

[3]  C. C. Macklin THE MUSCULATURE OF THE BRONCHI AND LUNGS , 1929 .

[4]  W. Chase The surface membrane of pulmonary alveolar walls. , 1959, Experimental Cell Research.

[5]  N. Staub,et al.  Ventilation of terminal air units. , 1962, Journal of applied physiology.

[6]  E. Weibel,et al.  A principle for counting tissue structures on random sections. , 1962, Journal of applied physiology.

[7]  A. C. Young,et al.  Mechanial properties of alveolar walls. , 1968, Journal of applied physiology.

[8]  J. West,et al.  Vertical gradient of alveolar size in lungs of dogs frozen intact. , 1967, Journal of applied physiology.

[9]  M. Dunnill,et al.  Effect of Lung Inflation on Alveolar Surface Area in the Dog , 1967, Nature.

[10]  E. Weibel,et al.  Principles and methods for the morphometric study of the lung and other organs. , 1963, Laboratory investigation; a journal of technical methods and pathology.

[11]  E. Gaensler,et al.  An analysis of factors affecting the measurement of pulmonary diffusing capacity by the single breath method. , 1961, The Journal of clinical investigation.

[12]  S. I. TOMKEIEFF,et al.  Linear Intercepts, Areas and Volumes , 1945, Nature.

[13]  R. Marshall Effect of lung inflation on bronchial dimensions in the dog. , 1962, Journal of applied physiology.