Monitoring of permeability of different analytes in human normal and cancerous bladder tissues in vitro using optical coherence tomography

We report our preliminary results on quantification of glucose and dimethyl sulfoxide (DMSO) diffusion in normal and cancerous human bladder tissues in vitro by using a spectral domain optical coherence tomography (SD-OCT). The permeability coefficients (PCs) of a 30% aqueous solution of glucose are found to be (7.92 ± 0.81) × 10-6 cm s-1 and (1.19 ± 0.13) × 10-5 cm s-1 in normal and cancerous bladder tissues, respectively. The PCs of 50% DMSO are calculated to be (8.99 ± 0.93) × 10-6 cm s-1 and (1.43 ± 0.17) × 10-5 cm s-1 in normal and cancerous bladder tissues, respectively. The obtained results show a statistically significant difference in permeability of normal and cancerous tissue and indicate that the PC of 50% DMSO is about 1.13-and 1.21-fold higher than that of 30% glucose in normal bladder and cancerous bladder tissues, respectively. Thus, the quantitative measurements with the help of PCs from OCT images can be a potentially powerful method for bladder cancer detection.

[1]  Huajiang Wei,et al.  Quantification of glycerol diffusion in human normal and cancer breast tissues in vitro with optical coherence tomography , 2010 .

[2]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[3]  M. Ascencio,et al.  Travail originalPlace et intérêt de la tomographie par cohérence optique en gynécologieThe place of optical coherence tomography in gynecology , 2007 .

[4]  Huajiang Wei,et al.  Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography , 2010 .

[5]  C. Compton,et al.  High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography. , 2000, Gastrointestinal endoscopy.

[6]  Kirill V Larin,et al.  Permeability of hyperosmotic agent in normal and atherosclerotic vascular tissues. , 2008, Journal of biomedical optics.

[7]  H. Herr,et al.  Reduced bladder tumour recurrence rate associated with narrow‐band imaging surveillance cystoscopy , 2011, BJU international.

[8]  Joseph C Liao,et al.  New optical imaging technologies for bladder cancer: considerations and perspectives. , 2012, The Journal of urology.

[9]  K. Ohbayashi,et al.  The impact of real-time 3d imaging by ultra-high speed optical coherence tomography in urothelial carcinoma , 2013, BMC Urology.

[10]  R. Esenaliev,et al.  Noninvasive monitoring of glucose concentration with optical coherence tomography , 2001 .

[11]  Valery V Tuchin,et al.  Nondestructive quantification of analyte diffusion in cornea and sclera using optical coherence tomography. , 2007, Investigative ophthalmology & visual science.

[12]  B. Geavlete,et al.  Narrow-band imaging cystoscopy in non-muscle-invasive bladder cancer: a prospective comparison to the standard approach , 2012, Therapeutic advances in urology.

[13]  Kirill V. Larin,et al.  Quantification of glucose diffusion in arterial tissues by using optical coherence tomography , 2007 .

[14]  M. Babjuk,et al.  Narrow band imaging cystoscopy improves the detection of non-muscle-invasive bladder cancer. , 2010, Urology.

[15]  Ton G van Leeuwen,et al.  A new generation of optical diagnostics for bladder cancer: technology, diagnostic accuracy, and future applications. , 2009, European urology.

[16]  Alvin C. Goh,et al.  Application of new technology in bladder cancer diagnosis and treatment , 2009, World Journal of Urology.

[17]  C. Bunce,et al.  The economic benefit of photodynamic diagnosis in non-muscle invasive bladder cancer. , 2008, Photodiagnosis and photodynamic therapy.

[18]  S. Mordon,et al.  Place et intérêt de la tomographie par cohérence optique en gynécologie , 2007 .

[19]  Georges Wagnières,et al.  Detection of early bladder carcinoma by fluorescence cystoscopy with Hexvix(R): improvement of the specificity by microcystoscopy , 2008, SPIE BiOS.

[20]  J Alfred Witjes,et al.  Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. , 2006, European urology.

[21]  Alvin T Yeh,et al.  Molecular interactions of exogenous chemical agents with collagen--implications for tissue optical clearing. , 2006, Journal of biomedical optics.

[22]  Bernard Choi,et al.  Revisiting optical clearing with dimethyl sulfoxide (DMSO) , 2009, Lasers in surgery and medicine.

[23]  Mesut Remzi,et al.  Fluorescence cystoscopy with high-resolution optical coherence tomography imaging as an adjunct reduces false-positive findings in the diagnosis of urothelial carcinoma of the bladder. , 2009, European urology.

[24]  Elena Zagaynova,et al.  Cross‐polarization optical coherence tomography for early bladder‐cancer detection: statistical study , 2011, Journal of biophotonics.

[25]  A. Jemal,et al.  Cancer Statistics, 2010 , 2010, CA: a cancer journal for clinicians.

[26]  V. Tuchin.  Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis , 2000 .

[27]  Application of hyperosmotic agent to determine gastric cancer with optical coherence tomography ex vivo in mice. , 2009, Journal of biomedical optics.

[28]  A. Saftoiu,et al.  Optical coherence tomography and Doppler optical coherence tomography in the gastrointestinal tract. , 2011, World journal of gastroenterology.

[29]  W. Drexler.  Ultrahigh-resolution optical coherence tomography. , 2004, Journal of biomedical optics.

[30]  J. Fujimoto,et al.  Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy. , 2000, Neoplasia.

[31]  Dieter Jocham,et al.  Hexyl aminolevulinate fluorescence cystoscopy: new diagnostic tool for photodiagnosis of superficial bladder cancer--a multicenter study. , 2003, The Journal of urology.

[32]  Valery V. Tuchin,et al.  Enhanced OCT imaging of embryonic tissue with optical clearing , 2008 .

[33]  Ton G van Leeuwen,et al.  Quantitative measurement of attenuation coefficients of bladder biopsies using optical coherence tomography for grading urothelial carcinoma of the bladder. , 2010, Journal of biomedical optics.

[34]  Huajiang Wei,et al.  Investigation of the permeability and optical clearing ability of different analytes in human normal and cancerous breast tissues by spectral domain OCT , 2012, Journal of biophotonics.

[35]  J Alfred Witjes,et al.  The role of hexaminolevulinate fluorescence cystoscopy in bladder cancer , 2007, Nature Clinical Practice Urology.

[36]  Valery V Tuchin,et al.  Differential permeability rate and percent clearing of glucose in different regions in rabbit sclera. , 2008, Journal of biomedical optics.

[37]  P. Vasudeva,et al.  Intravesical real-time imaging and staging of bladder cancer: Use of optical coherence tomography , 2008, Indian journal of urology : IJU : journal of the Urological Society of India.

[38]  A. Jemal,et al.  Cancer statistics, 2012 , 2012, CA: a cancer journal for clinicians.

[39]  R. Bryan,et al.  Emerging Endoscopic and Photodynamic Techniques for Bladder Cancer Detection and Surveillance , 2011, TheScientificWorldJournal.

[40]  Valery V. Tuchin,et al.  Optical clearing of tissues and blood using the immersion method , 2005 .

[41]  J. Au,et al.  Effect of dimethyl sulfoxide on bladder tissue penetration of intravesical paclitaxel. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[42]  Ruikang K. Wang,et al.  Dynamic optical clearing effect of tissue impregnated with hyperosmotic agents and studied with optical coherence tomography. , 2004, Journal of biomedical optics.

[43]  C. Pashos,et al.  The health economics of bladder cancer , 2012, PharmacoEconomics.

[44]  Daniel L. Farkas,et al.  Noninvasive imaging of biological tissue structure, function, and abnormalities with optical coherence tomography , 2000, Optics and Optoelectronic Inspection and Control.

[45]  Adrian Glasser,et al.  Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography , 2009, Journal of biophotonics.

[46]  Massoud Motamedi,et al.  Specificity of noninvasive blood glucose sensing using optical coherence tomography technique: a pilot study. , 2003, Physics in medicine and biology.

[47]  A. Goh,et al.  Optical coherence tomography as an adjunct to white light cystoscopy for intravesical real-time imaging and staging of bladder cancer. , 2007, Urology.

[48]  Huajiang Wei,et al.  Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography , 2012, Journal of biomedical optics.

[49]  Bernard Choi,et al.  Revisiting optical clearing with dimethyl sulfoxide (DMSO): in vitro and in vivo studies , 2009, BiOS.