Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation

[1]  T. Reinheckel,et al.  In Vivo Metabolic Imaging of [1-13C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen. , 2023, Angewandte Chemie.

[2]  Y. Yen,et al.  Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo. , 2023, Journal of magnetic resonance open.

[3]  J. Hövener,et al.  Modern Manufacturing Enables Magnetic Field Cycling Experiments and Parahydrogen-Induced Hyperpolarization with a Benchtop NMR. , 2023, Analytical chemistry.

[4]  K. Scheffler,et al.  LIGHT-SABRE Hyperpolarizes 1-13C-Pyruvate Continuously without Magnetic Field Cycling , 2023, The journal of physical chemistry. C, Nanomaterials and interfaces.

[5]  R. Herges,et al.  Parahydrogen-induced polarization and spin order transfer in ethyl pyruvate at high magnetic fields , 2022, Scientific Reports.

[6]  C. Bowers,et al.  Adiabatic Passage through Level Anticrossings in Systems of Chemically Inequivalent Protons Incorporating Parahydrogen: Theory, Experiment, and Prospective Applications. , 2022, Journal of the American Chemical Society.

[7]  C. Bowers,et al.  Perpetual Hyperpolarization of Allyl Acetate from Parahydrogen and Continuous Flow Heterogeneous Hydrogenation with Recycling of Unreacted Propargyl Acetate , 2022, Journal of Magnetic Resonance Open.

[8]  E. Gerasimov,et al.  Getting the Most out of Parahydrogen-Induced Signal Enhancement for MRI of Reacting Heterogeneous Systems , 2022, The Journal of Physical Chemistry C.

[9]  F. Sönnichsen,et al.  Synthesis of 13C and 2H Labeled Vinyl Pyruvate and Hyperpolarization of Pyruvate , 2022, Chemistry.

[10]  R. Gschwind,et al.  Deeper Insight into Photopolymerization: The Synergy of Time-Resolved Nonuniform Sampling and Diffusion NMR , 2022, Journal of the American Chemical Society.

[11]  J. Hövener,et al.  Performance and reproducibility of 13C and 15N hyperpolarization using a cryogen-free DNP polarizer , 2022, Scientific Reports.

[12]  S. Glöggler,et al.  A Field‐Independent Method for the Rapid Generation of Hyperpolarized [1‐13C]Pyruvate in Clean Water Solutions for Biomedical Applications , 2022, Angewandte Chemie.

[13]  J. Blanchard,et al.  Radio-Frequency Sweeps at Microtesla Fields for Parahydrogen-Induced Polarization of Biomolecules. , 2022, The journal of physical chemistry letters.

[14]  S. Becker,et al.  Rapidly Signal‐enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance , 2022, Chemistry–Methods.

[15]  J. Hennig,et al.  Quasi-continuous production of highly hyperpolarized carbon-13 contrast agents every 15 seconds within an MRI system , 2022, Communications Chemistry.

[16]  E. Chekmenev,et al.  Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques. , 2022, Analytical chemistry.

[17]  I. Koptyug,et al.  Symmetry Constraints on Spin Order Transfer in Parahydrogen-Induced Polarization (PHIP) , 2021, Symmetry.

[18]  Suyong Han,et al.  A Versatile Compact Parahydrogen Membrane Reactor. , 2021, Chemphyschem : a European journal of chemical physics and physical chemistry.

[19]  S. Aime,et al.  Effect of the hydrogenation solvent in the PHIP-SAH hyperpolarization of [1- 13 C]pyruvate , 2021, 2108.01497.

[20]  J. Hövener,et al.  Open-source, partially 3D-printed, high-pressure (50-bar) liquid-nitrogen-cooled parahydrogen generator , 2021, Magnetic Resonance.

[21]  R. Herges,et al.  Parahydrogen-Induced Polarization Relayed via Proton Exchange. , 2020, Journal of the American Chemical Society.

[22]  R. Acosta,et al.  Diffusion measurements with continuous hydrogenation in PHIP. , 2020, Journal of magnetic resonance.

[23]  G. Pileio,et al.  A temperature-controlled sample shuttle for field-cycling NMR. , 2020, Journal of magnetic resonance.

[24]  Y. Yen,et al.  SABRE polarized low field rare-spin spectroscopy. , 2020, The Journal of chemical physics.

[25]  S. Lehmkuhl,et al.  Automated pneumatic shuttle for magnetic field cycling and parahydrogen hyperpolarized multidimensional NMR. , 2020, Journal of magnetic resonance.

[26]  N. Chukanov,et al.  Quasi-Resonance Fluorine-19 Signal Amplification By Reversible Exchange. , 2019, The journal of physical chemistry letters.

[27]  J. Hennig,et al.  SAMBADENA Hyperpolarization of 13C‐Succinate in an MRI: Singlet‐Triplet Mixing Causes Polarization Loss , 2019, ChemistryOpen.

[28]  M. Utz,et al.  High-Resolution Nuclear Magnetic Resonance Spectroscopy with Picomole Sensitivity by Hyperpolarization on a Chip. , 2019, Journal of the American Chemical Society.

[29]  F. Sönnichsen,et al.  OnlyParahydrogen SpectrosopY (OPSY) pulse sequences - One does not fit all. , 2018, Journal of magnetic resonance.

[30]  J. Hövener,et al.  Only Para-Hydrogen Spectroscopy (OPSY) Revisited: In-Phase Spectra for Chemical Analysis and Imaging. , 2018, The journal of physical chemistry. A.

[31]  J. R. Petersen,et al.  Cryogen‐free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T , 2018, Magnetic resonance in medicine.

[32]  Alexej Jerschow,et al.  Parahydrogen-Based Hyperpolarization for Biomedicine. , 2018, Angewandte Chemie.

[33]  Eduard Y Chekmenev,et al.  Hyperpolarized NMR Spectroscopy: d-DNP, PHIP, and SABRE Techniques. , 2018, Chemistry, an Asian journal.

[34]  S. Glöggler,et al.  Over 50 % 1H and 13C Polarization for Generating Hyperpolarized Metabolites—A para‐Hydrogen Approach , 2018, ChemistryOpen.

[35]  J. Hennig,et al.  In vivo 13C-MRI using SAMBADENA , 2018, PloS one.

[36]  N. Chukanov,et al.  Synthesis of Unsaturated Precursors for Parahydrogen-Induced Polarization and Molecular Imaging of 1-13C-Acetates and 1-13C-Pyruvates via Side Arm Hydrogenation , 2018, ACS omega.

[37]  P. Rayner,et al.  Using parahydrogen to hyperpolarize amines, amides, carboxylic acids, alcohols, phosphates, and carbonates , 2018, Science Advances.

[38]  Rahul Aggarwal,et al.  Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Androgen Ablation Therapy in Prostate Cancer. , 2017, European urology.

[39]  G. Buntkowsky,et al.  A highly versatile automatized setup for quantitative measurements of PHIP enhancements. , 2017, Journal of magnetic resonance.

[40]  J. Hennig,et al.  Liquid-state carbon-13 hyperpolarization generated in an MRI system for fast imaging , 2017, Nature Communications.

[41]  J. Hennig,et al.  Molecular MRI in the Earth's Magnetic Field Using Continuous Hyperpolarization of a Biomolecule in Water. , 2016, The journal of physical chemistry. B.

[42]  J. Locasale,et al.  The Warburg Effect: How Does it Benefit Cancer Cells? , 2016, Trends in biochemical sciences.

[43]  K. Ivanov,et al.  A fast field-cycling device for high-resolution NMR: Design and application to spin relaxation and hyperpolarization experiments. , 2016, Journal of magnetic resonance.

[44]  S. Aime,et al.  Effects of Magnetic Field Cycle on the Polarization Transfer from Parahydrogen to Heteronuclei through Long-Range J-Couplings. , 2015, The journal of physical chemistry. B.

[45]  L. Bouchard,et al.  A nanoparticle catalyst for heterogeneous phase para-hydrogen-induced polarization in water. , 2015, Angewandte Chemie.

[46]  M. Halse,et al.  Photochemical pump and NMR probe: chemically created NMR coherence on a microsecond time scale. , 2014, Journal of the American Chemical Society.

[47]  P. Larson,et al.  Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate , 2013, Science Translational Medicine.

[48]  K. Ivanov,et al.  Manipulating spin hyper-polarization by means of adiabatic switching of a spin-locking RF-field. , 2013, Physical chemistry chemical physics : PCCP.

[49]  J. Hennig,et al.  A continuous‐flow, high‐throughput, high‐pressure parahydrogen converter for hyperpolarization in a clinical setting , 2013, NMR in biomedicine.

[50]  J. Hennig,et al.  On the spin order transfer from parahydrogen to another nucleus. , 2012, Journal of magnetic resonance.

[51]  A. Haase FLASH MR imaging: a success story since 25 years. , 2011, Journal of magnetic resonance.

[52]  R. Rizi,et al.  A simple and low‐cost device for generating hyperpolarized contrast agents using parahydrogen , 2011, NMR in biomedicine.

[53]  K. D. Atkinson,et al.  Iridium N-Heterocyclic Carbene Complexes as Efficient Catalysts for Magnetization Transfer from para-Hydrogen , 2011, Journal of the American Chemical Society.

[54]  E. Chekmenev,et al.  In situ detection of PHIP at 48 mT: demonstration using a centrally controlled polarizer. , 2011, Journal of the American Chemical Society.

[55]  R. Rizi,et al.  Optimal transfer of spin-order between a singlet nuclear pair and a heteronucleus. , 2010, Journal of magnetic resonance (San Diego, Calif. 1997 : Print).

[56]  Adolf Pfefferbaum,et al.  Metabolic imaging in the anesthetized rat brain using hyperpolarized [1‐13C] pyruvate and [1‐13C] ethyl pyruvate , 2010, Magnetic resonance in medicine.

[57]  W. Perman,et al.  PASADENA hyperpolarization of 13C biomolecules: equipment design and installation , 2009, Magnetic Resonance Materials in Physics, Biology and Medicine.

[58]  K. D. Atkinson,et al.  Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer , 2009, Science.

[59]  Brian D Ross,et al.  Towards hyperpolarized (13)C-succinate imaging of brain cancer. , 2007, Journal of magnetic resonance.

[60]  A. Pines,et al.  para-Hydrogen-induced polarization in heterogeneous hydrogenation reactions. , 2007, Journal of the American Chemical Society.

[61]  Oskar Axelsson,et al.  Design and implementation of 13C hyper polarization from para-hydrogen, for new MRI contrast agents , 2006 .

[62]  Valerie A. Norton,et al.  Ultra-fast three dimensional imaging of hyperpolarized 13C in vivo , 2005, Magnetic Resonance Materials in Physics, Biology and Medicine.

[63]  M. Goldman,et al.  Conversion of a proton pair para order into 13C polarization by rf irradiation, for use in MRI , 2005 .

[64]  Oskar Axelsson,et al.  Hyperpolarization of 13C through order transfer from parahydrogen: a new contrast agent for MRI. , 2005, Magnetic resonance imaging.

[65]  J. Ardenkjær-Larsen,et al.  Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[66]  H. Jóhannesson,et al.  Parahydrogen‐induced polarization in imaging: Subsecond 13C angiography , 2001, Magnetic resonance in medicine.

[67]  John C. Lindon,et al.  Improved WATERGATE Pulse Sequences for Solvent Suppression in NMR Spectroscopy , 1998 .

[68]  R. Freeman,et al.  A New Excitation Sequence to Observe the PASADENA Effect , 1996 .

[69]  Richard Eisenberg,et al.  Para hydrogen induced polarization in hydrogenation reactions , 1987 .

[70]  Daniel P. Weitekamp,et al.  Parahydrogen and synthesis allow dramatically enhanced nuclear alignment , 1987 .

[71]  C. Griesinger,et al.  Similarity of SABRE field dependence in chemically different substrates. , 2012, Journal of magnetic resonance.

[72]  Richard R. Ernst,et al.  Product operator formalism for the description of NMR pulse experiments , 1984 .