PRESENT STATUS OF IMMUNISATION AGAINST TUBERCULOSIS

The discovery of the tubercle bacillus by Robert Koch in 1882 and his classical demonstration, in 1891, of the effect of a second infection with tubercle bacilli in an already tuberculous guinea pig, which later came to be known as the ‘Koch phenomenon’, heralded scores of attempts to develop a specific immunising agent against tuberculosis, derived from the tubercle bacillus. The attempts were indeed inspired by the observations of Edward Jenner who about a hundred years earlier, in 1798, had also noticed the increased reactivity to vaccinia virus occurring in persons who had been previously vaccinated or who had had smallpox.

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