Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
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Florian Engert | Joachim Weischenfeldt | Jan Smida | Michaela Nathrath | Daniel Baumhoer | Ian Tomlinson | Hans Rechl | Nikola S Mueller | Katja Specht | Klaus-Dieter Schaser | Ingo Melcher | Andreas Kulozik | Jan O Korbel | Simone Fulda | Per-Ulf Tunn | F. Engert | K. Schaser | J. Korbel | I. Tomlinson | F. Castro-Giner | S. Fulda | J. Weischenfeldt | N. Mueller | S. Bielack | K. Specht | S. Burdach | A. Kulozik | C. Blattmann | D. Baumhoer | M. Nathrath | H. Dürr | D. Andreou | P. Tunn | K. Heinimann | H. Rechl | G. Jundt | Stefan Burdach | Karl Heinimann | M. Kovac | J. Smida | S. Ribi | Monika Kováčová | Hans Roland Dürr | Francesc Castro-Giner | Stefan Bielack | I. Melcher | Gernot Jundt | Michal Kovac | Claudia Blattmann | A. Krieg | Dimosthenis Andreou | Sebastian Ribi | Monika Kovacova | Andreas Krieg | M. Kovác
[1] Yan Shi,et al. Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors , 2015, Molecular Cancer Research.
[2] James M Ford,et al. Phase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Therapy for Triple-Negative and BRCA1/2 Mutation-Associated Breast Cancer With Assessment of a Tumor-Based Measure of Genomic Instability: PrECOG 0105. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[3] J. Yong,et al. MicroRNA-22 Suppresses DNA Repair and Promotes Genomic Instability through Targeting of MDC1. , 2015, Cancer research.
[4] W. Sung,et al. TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome , 2015, Oncotarget.
[5] S. Keir,et al. Initial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program: PALB2 mutation predicts exceptional in vivo response to BMN 673 , 2015, Pediatric blood & cancer.
[6] Julian Gehring,et al. SomaticSignatures: inferring mutational signatures from single-nucleotide variants , 2014, bioRxiv.
[7] S. Keir,et al. Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program , 2014, Clinical Cancer Research.
[8] Adam Kiezun,et al. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma , 2014, Proceedings of the National Academy of Sciences.
[9] H. Walden,et al. The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder. , 2014, Annual review of biophysics.
[10] J. Squire,et al. Digital Expression Profiling Identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as Potential Predictive Biomarkers for Neo-Adjuvant Chemotherapy Response in Paediatric Osteosarcoma , 2014, PloS one.
[11] L. Wiesmüller,et al. NuMA promotes homologous recombination repair by regulating the accumulation of the ISWI ATPase SNF2h at DNA breaks , 2014, Nucleic acids research.
[12] Li Ding,et al. Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. , 2014, Cell reports.
[13] A. Bouchard-Côté,et al. PyClone: statistical inference of clonal population structure in cancer , 2014, Nature Methods.
[14] Yuchen Jiao,et al. Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas , 2014, Genes, chromosomes & cancer.
[15] Hao Liu,et al. RECQ DNA helicases and osteosarcoma. , 2014, Advances in experimental medicine and biology.
[16] Michael P. Schroeder,et al. IntOGen-mutations identifies cancer drivers across tumor types , 2013, Nature Methods.
[17] David T. W. Jones,et al. Signatures of mutational processes in human cancer , 2013, Nature.
[18] A. Vincent-Salomon,et al. Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation. , 2012, Cancer research.
[19] G. Mills,et al. Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer , 2012, British Journal of Cancer.
[20] L. Thompson. Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography. , 2012, Mutation research.
[21] A. Børresen-Dale,et al. Mutational Processes Molding the Genomes of 21 Breast Cancers , 2012, Cell.
[22] K. Lindblad-Toh,et al. Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach. , 2011, Bone.
[23] A. Cleton-Jansen,et al. Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma , 2010, Genes, chromosomes & cancer.
[24] M. Dyer,et al. The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. , 2010, Blood.
[25] Nuria Lopez-Bigas,et al. IntOGen: integration and data mining of multidimensional oncogenomic data , 2010, Nature Methods.
[26] Alun Thomas,et al. Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. , 2009, American journal of human genetics.
[27] Jung-Sik Kim,et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors , 2009, EMBO molecular medicine.
[28] G. Ottaviani,et al. The etiology of osteosarcoma. , 2009, Cancer treatment and research.
[29] Y. Yin,et al. PTEN: a new guardian of the genome , 2008, Oncogene.
[30] E. Lander,et al. Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma , 2007, Proceedings of the National Academy of Sciences.
[31] A. Ashworth,et al. Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility. , 2007, Human molecular genetics.
[32] E. Kritikou. Tumorigenesis: PTEN — a new guardian of the genome , 2007, Nature Reviews Cancer.
[33] Alan Ashworth,et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. , 2006, Cancer research.
[34] H. Morreau,et al. Chromosomal instability in MYH- and APC-mutant adenomatous polyps. , 2006, Cancer research.
[35] O. Sansom,et al. Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. , 2005, Cancer research.
[36] L. Zhuang,et al. Characterization of FGFRL1, a Novel Fibroblast Growth Factor (FGF) Receptor Preferentially Expressed in Skeletal Tissues* , 2003, Journal of Biological Chemistry.
[37] E. Zackai,et al. Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. , 2003, Journal of the National Cancer Institute.
[38] W. Winkelmann,et al. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[39] I. Hickson,et al. DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. , 2001, Human molecular genetics.
[40] Y. Ishikawa,et al. A Case of Werner's Syndrome Associated with Osteosarcoma , 1999, The Journal of dermatology.
[41] Acknowledgements , 1992, Experimental Gerontology.