Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

[1]  D. Grimm,et al.  The role of SOX family members in solid tumours and metastasis. , 2020, Seminars in cancer biology.

[2]  C. Dienemann,et al.  Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function , 2020, Nature.

[3]  C. Fugazza,et al.  SOX6 blocks the proliferation of BCR-ABL1+ and JAK2V617F+ leukemic cells , 2019, Scientific Reports.

[4]  P. Bovolenta,et al.  Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance , 2019, Cell stem cell.

[5]  J. Forwood,et al.  Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses , 2018, Nature Communications.

[6]  R. Takagi,et al.  Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma , 2018, Oncology reports.

[7]  N. Cowieson,et al.  MX2: a high-flux undulator microfocus beamline serving both the chemical and macromolecular crystallography communities at the Australian Synchrotron , 2018, Journal of synchrotron radiation.

[8]  Yong Feng,et al.  Functional analysis of a SOX10 gene mutation associated with Waardenburg syndrome II. , 2017, Biochemical and biophysical research communications.

[9]  R. Gillilan,et al.  Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1 , 2017, Nature Communications.

[10]  V. Lefebvre,et al.  SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells. , 2017, Cancer research.

[11]  A. Rizzino,et al.  The dark side of SOX2: cancer - a comprehensive overview , 2017, Oncotarget.

[12]  Wan-Xi Yang,et al.  Nucleocytoplasmic shuttling of SOX14A and SOX14B transcription factors , 2017, Oncotarget.

[13]  Wufang Fan,et al.  A Novel Missense Mutation 224G>T (R75M) in SRY Coding Region Interferes with Nuclear Import and Results in 46, XY Complete Gonadal Dysgenesis , 2016, PloS one.

[14]  J. Forwood,et al.  Structural insights into the assembly and regulation of distinct viral capsid complexes , 2016, Nature Communications.

[15]  Wan-Xi Yang,et al.  SOX family transcription factors involved in diverse cellular events during development. , 2015, European journal of cell biology.

[16]  M. Blackledge,et al.  Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors , 2015, Cell.

[17]  M. Konantz,et al.  Molecular and functional interactions between AKT and SOX2 in breast carcinoma , 2015, Oncotarget.

[18]  Hyun-soo Cho,et al.  Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation , 2015, Journal of Cell Science.

[19]  Rui Li,et al.  Overexpression of SOX2 is involved in paclitaxel resistance of ovarian cancer via the PI3K/Akt pathway , 2015, Tumor Biology.

[20]  G. Cingolani,et al.  Diversification of importin-α isoforms in cellular trafficking and disease states. , 2015, The Biochemical journal.

[21]  N. Cowieson,et al.  MX1: a bending-magnet crystallography beamline serving both chemical and macromolecular crystallography communities at the Australian Synchrotron , 2015, Journal of synchrotron radiation.

[22]  Wei Xu,et al.  Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1. , 2014, Cell host & microbe.

[23]  M. Foti,et al.  Sox2 is required to maintain cancer stem cells in a mouse model of high-grade oligodendroglioma. , 2014, Cancer research.

[24]  Bostjan Kobe,et al.  Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20 , 2013, PloS one.

[25]  W. Sung,et al.  Chromatin connectivity maps reveal dynamic promoter–enhancer long-range associations , 2013, Nature.

[26]  Bruno M. Simões,et al.  Sox2 promotes tamoxifen resistance in breast cancer cells , 2013, EMBO molecular medicine.

[27]  H. Kondoh,et al.  Sox proteins: regulators of cell fate specification and differentiation , 2013, Development.

[28]  M. Weiss,et al.  Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold , 2013, Proceedings of the National Academy of Sciences.

[29]  B. Kobe,et al.  Structural Basis of High‐Affinity Nuclear Localization Signal Interactions with Importin‐α , 2012, Traffic.

[30]  E. Lai,et al.  Ars2 maintains neural stem cell identity via direct transcriptional activation of Sox2 , 2011, Nature.

[31]  Owen Johnson,et al.  iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM , 2011, Acta crystallographica. Section D, Biological crystallography.

[32]  Randy J. Read,et al.  Overview of the CCP4 suite and current developments , 2011, Acta crystallographica. Section D, Biological crystallography.

[33]  Debasis Mondal,et al.  Prognostic significance of cytoplasmic SOX9 in invasive ductal carcinoma and metastatic breast cancer , 2011, Experimental biology and medicine.

[34]  E. Rassart,et al.  Importin α3 Interacts with HIV-1 Integrase and Contributes to HIV-1 Nuclear Import and Replication , 2010, Journal of Virology.

[35]  J. Forwood,et al.  Calmodulin-dependent nuclear import of HMG-box family nuclear factors: importance of the role of SRY in sex reversal , 2010, The Biochemical journal.

[36]  B. Boizet-Bonhoure,et al.  Shuttling of SOX proteins. , 2010, The international journal of biochemistry & cell biology.

[37]  Vincent B. Chen,et al.  PHENIX: a comprehensive Python-based system for macromolecular structure solution , 2010, Acta crystallographica. Section D, Biological crystallography.

[38]  Jessica Mariani,et al.  Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh , 2009, Nature Neuroscience.

[39]  Jeroen A. A. Demmers,et al.  Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors , 2009, The Journal of cell biology.

[40]  Jessica Mariani,et al.  Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants , 2008, Development.

[41]  J. Samarut,et al.  A Mechanism Regulating the Onset of Sox2 Expression in the Embryonic Neural Plate , 2008, PLoS biology.

[42]  G. Pan,et al.  A Dominant-negative Form of Mouse SOX2 Induces Trophectoderm Differentiation and Progressive Polyploidy in Mouse Embryonic Stem Cells* , 2007, Journal of Biological Chemistry.

[43]  Alexei A. Sharov,et al.  Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells , 2007, Nature Cell Biology.

[44]  R. Maas,et al.  Sox2 and Pou2f1 interact to control lens and olfactory placode development. , 2007, Developmental biology.

[45]  V. Volchkov,et al.  Ebola Virus VP24 Binds Karyopherin α1 and Blocks STAT1 Nuclear Accumulation , 2006, Journal of Virology.

[46]  A. Clayton,et al.  Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal. , 2005, Molecular endocrinology.

[47]  D. Goldfarb,et al.  Importin α: A multipurpose nuclear-transport receptor , 2004 .

[48]  B. Wainwright,et al.  Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant‐negative mechanism , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[49]  A. Clayton,et al.  A SOX9 Defect of Calmodulin-dependent Nuclear Import in Campomelic Dysplasia/Autosomal Sex Reversal* , 2003, Journal of Biological Chemistry.

[50]  J. Forwood,et al.  Defective importin β recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[51]  V. Harley,et al.  Biochemical defects in eight SRY missense mutations causing XY gonadal dysgenesis. , 2002, Molecular genetics and metabolism.

[52]  M. Wegner,et al.  Sox10 Is an Active Nucleocytoplasmic Shuttle Protein, and Shuttling Is Crucial for Sox10-Mediated Transactivation , 2002, Molecular and Cellular Biology.

[53]  J. Forwood,et al.  The C-terminal Nuclear Localization Signal of the Sex-determining Region Y (SRY) High Mobility Group Domain Mediates Nuclear Import through Importin β1* , 2001, The Journal of Biological Chemistry.

[54]  M. Weiss,et al.  Human Sex Reversal Due to Impaired Nuclear Localization of SRY , 2001, The Journal of Biological Chemistry.

[55]  W. A. Johnson,et al.  Functional Interactions between DrosophilabHLH/PAS, Sox, and POU Transcription Factors Regulate CNS Midline Expression of the slit Gene , 2000, The Journal of Neuroscience.

[56]  S. Russell,et al.  The Drosophila dominant wing mutation Dichaete results from ectopic expression of a Sox-domain gene , 2000, Molecular and General Genetics MGG.

[57]  C. Müller,et al.  Structure of importin-beta bound to the IBB domain of importin-alpha. , 1999, Nature.

[58]  C. Müller,et al.  Structure of importin-β bound to the IBB domain of importin-α , 1999, Nature.

[59]  G. Scherer,et al.  Two Independent Nuclear Localization Signals Are Present in the DNA-binding High-mobility Group Domains of SRY and SOX9* , 1997, The Journal of Biological Chemistry.

[60]  N. Lamb,et al.  Nuclear localization of the testis determining gene product SRY , 1995, The Journal of cell biology.

[61]  P. Dzięgiel,et al.  Prognostic significance of SOX18 expression in non-small cell lung cancer. , 2015, International journal of oncology.

[62]  E. Vilain,et al.  Human SRY inhibits beta-catenin-mediated transcription. , 2008, The international journal of biochemistry & cell biology.

[63]  Hisato Kondoh,et al.  Triggering neural differentiation of ES cells by subtype switching of importin-α , 2007, Nature Cell Biology.

[64]  V. Volchkov,et al.  Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation. , 2006, Journal of virology.

[65]  D. Goldfarb,et al.  Importin alpha: a multipurpose nuclear-transport receptor. , 2004, Trends in cell biology.

[66]  R. Lovell-Badge,et al.  Multipotent cell lineages in early mouse development depend on SOX2 function. , 2003, Genes & development.

[67]  A. Mukherjee,et al.  The Drosophila sox gene, fish-hook, is required for postembryonic development. , 2000, Developmental biology.

[68]  P. Evans.  Biological Crystallography an Introduction to Data Reduction: Space-group Determination, Scaling and Intensity Statistics , 2022 .