Automated classification system for Bone Age X-ray images

Bone Age (BA) determination using radiological images of left hands and wrists is important in pediatric endocrinology to correctly assess growth and pubertal maturation. In this paper, we propose a fully automated Greulich and Pyle Atlas (GP) bone age determination system using feature extraction and machine learning classifiers. The original contributions of this paper are as follows: (i) We use commercially available morphing tools to create a modified GP atlas that has images regularly spaced at three month intervals, (ii) We propose a novel Singular Value Decomposition (SVD) based feature extractor to create a feature vector. We use the Scale Invariant Feature Transform (SIFT) to extract features from the images then apply SVD to compose the feature vectors. Then, we train a Neural Network classifier using the generated feature vectors. Our preliminary results show that, even with a small number of training data sets, we obtain promising results. Future direction is discussed.

[1]  F ROSENBLATT,et al.  The perceptron: a probabilistic model for information storage and organization in the brain. , 1958, Psychological review.

[2]  E. Andersen Comparison of Tanner-Whitehouse and Greulich-Pyle methods in a large scale Danish Survey. , 1971, American journal of physical anthropology.

[3]  David G. Lowe,et al.  Distinctive Image Features from Scale-Invariant Keypoints , 2004, International Journal of Computer Vision.

[4]  Andrea Vedaldi,et al.  Vlfeat: an open and portable library of computer vision algorithms , 2010, ACM Multimedia.

[5]  G LoweDavid,et al.  Distinctive Image Features from Scale-Invariant Keypoints , 2004 .

[6]  Marcos Martín-Fernández,et al.  Automatic bone age assessment: a registration approach , 2003, SPIE Medical Imaging.

[7]  Chong-Wah Ngo,et al.  Evaluating bag-of-visual-words representations in scene classification , 2007, MIR '07.

[8]  W. Greulich,et al.  Radiographic Atlas of Skeletal Development of the Hand and Wrist , 1999 .

[9]  E. Brandser,et al.  Effect of knowledge of chronologic age on the variability of pediatric bone age determined using the Greulich and Pyle standards. , 2001, AJR. American journal of roentgenology.

[10]  David G. Lowe,et al.  Object recognition from local scale-invariant features , 1999, Proceedings of the Seventh IEEE International Conference on Computer Vision.

[11]  Sven Kreiborg,et al.  The BoneXpert Method for Automated Determination of Skeletal Maturity , 2009, IEEE Transactions on Medical Imaging.

[12]  H. K. Huang,et al.  Bone age assessment of children using a digital hand atlas , 2007, Comput. Medical Imaging Graph..

[13]  Hans Henrik Thodberg Hands-on experience with active appearance models , 2002, SPIE Medical Imaging.

[14]  M. Maresh,et al.  Radiographic Atlas of Skeletal Development of the Hand and Wrist , 1950 .

[15]  J M Tanner,et al.  ADVANTAGES OF THE COMPUTER-AIDED IMAGE ANALYSIS SYSTEM FOR ESTIMATING TW SKELETAL MATURITY: INCREASED RELIABILITY AND A CONTINUOUS SCALE , 1993, Pediatric Research.

[16]  Timothy F. Cootes,et al.  Active Appearance Models , 1998, ECCV.

[17]  Hans Henrik Thodberg,et al.  Clinical application of automated Greulich-Pyle bone age determination in children with short stature , 2009, Pediatric Radiology.

[18]  H. K. Huang,et al.  Computer-assisted bone age assessment: image preprocessing and epiphyseal/metaphyseal ROI extraction , 2001, IEEE Transactions on Medical Imaging.