Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification.

[1]  B. Rubin,et al.  Secretory phospholipases A2 stimulate mucus secretion, induce airway inflammation, and produce secretory hyperresponsiveness to neutrophil elastase in ferret trachea. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[2]  P. Elias,et al.  Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing. , 2006, The Journal of investigative dermatology.

[3]  A. Burdick,et al.  The role of peroxisome proliferator-activated receptor-beta/delta in epithelial cell growth and differentiation. , 2006, Cellular signalling.

[4]  T. Willson,et al.  PPARbeta/delta selectively induces differentiation and inhibits cell proliferation. , 2006, Cell death and differentiation.

[5]  T. Willson,et al.  PPARβ/δ selectively induces differentiation and inhibits cell proliferation , 2006, Cell Death and Differentiation.

[6]  P. Elias,et al.  Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate. , 2005, The Journal of investigative dermatology.

[7]  Alfonso T. Perez,et al.  A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia. , 2005, Diabetes care.

[8]  R. Schmidt,et al.  Säuremantel der Haut und Bakterienabwehr , 1939, Klinische Wochenschrift.

[9]  A. Marchionini,et al.  Säuremantel der haut und Bakterienabwehr , 1938, Klinische Wochenschrift.

[10]  A. Marchionini,et al.  Zur physikalischen Chemie der Hautoberfläche , 1928, Archiv für Dermatologie und Syphilis.

[11]  M. Brattsand,et al.  A proteolytic cascade of kallikreins in the stratum corneum. , 2005, The Journal of investigative dermatology.

[12]  P. Chambon,et al.  Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. , 2004, The Journal of investigative dermatology.

[13]  P. Elias,et al.  Functional consequences of a neutral pH in neonatal rat stratum corneum. , 2004, The Journal of investigative dermatology.

[14]  J. Saurat,et al.  Peroxisome proliferator-activated receptors as new molecular targets in psoriasis. , 2004, Current drug targets. Inflammation and allergy.

[15]  T. Willson,et al.  Peroxisome Proliferator-Activated Receptor (PPAR)-β/δ Stimulates Differentiation and Lipid Accumulation in Keratinocytes , 2004 .

[16]  P. Elias,et al.  Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum. , 2004, The Journal of investigative dermatology.

[17]  T. Willson,et al.  Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. , 2004, The Journal of investigative dermatology.

[18]  A. Zlotogorski.  Distribution of skin surface pH on the forehead and cheek of adults , 2004, Archives of Dermatological Research.

[19]  A. A. Hartmann.  Effect of occlusion on resident flora, skin-moisture and skin-pH , 2004, Archives of Dermatological Research.

[20]  J. Saurat,et al.  Peroxisome proliferator‐activated receptors in cutaneous biology , 2003, The British journal of dermatology.

[21]  Kenneth R Feingold,et al.  pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. , 2003, The Journal of investigative dermatology.

[22]  E. Gratton,et al.  Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function. , 2003, The Journal of investigative dermatology.

[23]  Enrico Gratton,et al.  NHE1 Regulates the Stratum Corneum Permeability Barrier Homeostasis , 2002, The Journal of Biological Chemistry.

[24]  J. Auwerx,et al.  Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero. , 2002, The Journal of investigative dermatology.

[25]  P. Elias,et al.  Stratum corneum pH: Formation and Function of the ‘Acid Mantle’ , 2002, Exogenous Dermatology.

[26]  P. Elias,et al.  Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double‐blind study , 2002, The British journal of dermatology.

[27]  P. Hoeger,et al.  Skin Physiology of the Neonate and Young Infant: A Prospective Study of Functional Skin Parameters During Early Infancy , 2002, Pediatric dermatology.

[28]  H. Sugiya,et al.  4-Bromophenacyl bromide induces Ca2+ influx in human gingival fibroblasts. , 2002, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[29]  J. Auwerx,et al.  Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero. , 2002, The Journal of investigative dermatology.

[30]  Béatrice Desvergne,et al.  PPAR expression and function during vertebrate development. , 2002, The International journal of developmental biology.

[31]  E. Berardesca,et al.  Differences in Corneocyte Surface Area in Pre- and Post-Menopausal Women , 2001, Skin Pharmacology and Physiology.

[32]  P. Elias,et al.  Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity. , 2001, The Journal of investigative dermatology.

[33]  K. Kristiansen,et al.  Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid. , 2001, The Journal of investigative dermatology.

[34]  S. Seidenari,et al.  Skin Barrier, Hydration, and pH of the Skin of Infants Under 2 Years of Age , 2001, Pediatric dermatology.

[35]  J. Fluhr,et al.  Direct Comparison of Skin Physiology in Children and Adults with Bioengineering Methods , 2000, Pediatric dermatology.

[36]  J. Auwerx,et al.  Stimulation of PPARα Promotes Epidermal Keratinocyte Differentiation In Vivo , 2000 .

[37]  M. Kermici,et al.  Evidence for the existence of a self-regulated enzymatic process within the human stratum corneum -an unexpected role for urocanic acid. , 2000, The Journal of investigative dermatology.

[38]  L. Sirota,et al.  Skin Barrier Properties in Different Body Areas in Neonates , 2000, Pediatrics.

[39]  J. Ring,et al.  Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children. , 2000, Acta dermato-venereologica.

[40]  X. Shen,et al.  Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone. , 2000, Diabetes.

[41]  Y. Gall,et al.  Identification of pancreatic type I secreted phospholipase A2 in human epidermis and its determination by tape stripping , 2000, The British journal of dermatology.

[42]  M. Visscher,et al.  Changes in Diapered and Nondiapered Infant Skin Over the First Month of Life , 2000, Pediatric dermatology.

[43]  J. Auwerx,et al.  Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. , 2000, The Journal of investigative dermatology.

[44]  P. Elias,et al.  Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. , 1999, The Journal of investigative dermatology.

[45]  C. De Simone,et al.  Effect of the lactic acid bacterium Streptococcus thermophilus on ceramide levels in human keratinocytes in vitro and stratum corneum in vivo. , 1999, The Journal of investigative dermatology.

[46]  A. Edström,et al.  Involvement of axonal phospholipase A2 activity in the outgrowth of adult mouse sensory axons in vitro , 1999, Neuroscience.

[47]  J. Mazuski,et al.  The effect of phospholipase A2 inhibitors on proliferation and apoptosis of murine intestinal cells. , 1999, The Journal of surgical research.

[48]  G. Imokawa,et al.  Beta-glucocerebrosidase activity in mammalian stratum corneum. , 1999, Journal of lipid research.

[49]  J. Lehmann,et al.  The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways. , 1999, Recent progress in hormone research.

[50]  Pirot.,et al.  Differences in stratum corneum pH gradient when comparing white caucasian and black African‐American skin , 1998, The British journal of dermatology.

[51]  P. Elias,et al.  Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development. , 1998, The Journal of investigative dermatology.

[52]  D. Thueson,et al.  The Roles of pH and Concentration in Lactic Acid‐induced Stimulation of Epidermal Turnover , 1998, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[53]  P. Elias,et al.  Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha. , 1998, The Journal of investigative dermatology.

[54]  G. Ailhaud,et al.  Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes. , 1998, The Journal of investigative dermatology.

[55]  H. Maibach,et al.  Time-dependent variations of the skin barrier function in humans: transepidermal water loss, stratum corneum hydration, skin surface pH, and skin temperature. , 1998, The Journal of investigative dermatology.

[56]  L. Franck,et al.  Disruption of barrier function in neonatal skin associated with adhesive removal. , 1997, The Journal of pediatrics.

[57]  P. Elias,et al.  Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier. , 1997, The Journal of clinical investigation.

[58]  W Ament,et al.  Lactate and Ammonia Concentration in Blood and Sweat During Incremental Cycle Ergometer Exercise , 1997, International journal of sports medicine.

[59]  P. Elias,et al.  Secretory phospholipase A2 activity is required for permeability barrier homeostasis. , 1996, The Journal of investigative dermatology.

[60]  S. Seidenari,et al.  Objective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin. , 1995, Acta dermato-venereologica.

[61]  P. Elias,et al.  Extracellular processing of phospholipids is required for permeability barrier homeostasis. , 1995, Journal of lipid research.

[62]  E. Ginns,et al.  Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. , 1994, The Journal of clinical investigation.

[63]  P. Elias,et al.  Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function. , 1993, The Journal of clinical investigation.

[64]  G. Imokawa,et al.  beta-Glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation. , 1992, Journal of lipid research.

[65]  J. Urban,et al.  Influence of the pH-value on the growth of Staphylococcus epidermidis, Staphylococcus aureus and Propionibacterium acnes in continuous culture. , 1992, Zentralblatt fur Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine.

[66]  Mahendra K. Jain,et al.  Active-site-directed specific competitive inhibitors of phospholipase A2: novel transition-state analogues. , 1991, Biochemistry.

[67]  S. White,et al.  Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction. , 1991, The Journal of investigative dermatology.

[68]  O. Braun-falco,et al.  Differences in the skin surface pH and bacterial microflora due to the long-term application of synthetic detergent preparations of pH 5.5 and pH 7.0. Results of a crossover trial in healthy volunteers. , 1990, Acta dermato-venereologica.

[69]  P. Elias,et al.  Antimicrobial activity of stratum corneum lipids from normal and essential fatty acid-deficient mice. , 1989, The Journal of investigative dermatology.

[70]  C. Bon,et al.  A sensitive and continuous fluorometric assay for phospholipase A2 using pyrene-labeled phospholipids in the presence of serum albumin. , 1989, Analytical biochemistry.

[71]  A. Schönberger,et al.  Distribution of urocanic acid in human stratum corneum. , 1986, Photo-dermatology.

[72]  O. Braun-falco,et al.  [Normal pH value of human skin]. , 1986, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.

[73]  S M Puhvel,et al.  Analysis of lipid composition of isolated human sebaceous gland homogenates after incubation with cutaneous bacteria. Thin-layer chromatography. , 1975, The Journal of investigative dermatology.

[74]  H. Maibach,et al.  Correlation of human in vivo and in vitro cutaneous antimicrobial factors. , 1975, The Journal of infectious diseases.

[75]  H. Tippelt.  Zur Hautoberflächen-pH-Messung und Alkaliresistenzprobe bei Hautgesunden und Ichthyosis vulgaris-Kranken , 1969 .

[76]  M. Pathak,et al.  The metabolism and function of urocanic acid in skin. , 1967, The Journal of investigative dermatology.

[77]  C. Hailey,et al.  pH determinations of the skin. Readings under normal and abnormal conditions. , 1961, The Journal of investigative dermatology.

[78]  D. W. Neill,et al.  THE EFFECT OF AGE ON THE pH OF THE SKIN SURFACE IN THE FIRST WEEK OF LIFE. , 1960, The British journal of dermatology.

[79]  M. Green,et al.  Skin pH pattern in the newborn infant. , 1958, A.M.A. journal of diseases of children.

[80]  H. Arbenz.  Untersuchungen über die pH-Werte der normalen Hautoberfläehe , 1952 .

[81]  J. H. Draize.  The Determination of the pH of the Skin of Man and Common Laboratory Animals , 1942 .

[82]  I. H. Blank.  Measurement of pH of the Skin Surface12: II. pH of the Exposed Surfaces of Adults with No Apparent Skin Lesions , 1939 .